Ryan Lingg

Semaglutide drives weight loss through cAMP-dependent mechanisms in GLP1R-expressing hindbrain neurons Glucagon-like peptide 1 receptor (GLP1R) agonists like semaglutide drive weight loss through the brain, but insights into their intracellular signaling mechanisms are lacking. Although canonically GLP...

Rigorous dissection of the signaling mechanisms and circuits underlying GLP1R agonist weight loss effects mice. Huge achievement by Claire Gao and team @mikekrashes.bsky.social. Potential avenues for harnessing complexity of signaling to create novel treatments. www.biorxiv.org/content/10.1...

Acute and circadian feedforward regulation of agouti-related peptide hunger neurons Douglass et al. employ long-term, continuous fiber photometry to uncover new modes of agouti-related peptide (AgRP) neuron regulation in ad libitum, fasted, and circadian conditions. AgRP neuron activity exhibits a circadian rhythm, which controls daily feeding patterns through a neural circuit from the suprachiasmatic nucleus via the dorsomedial hypothalamus.

I’m excited to share my latest paper
@cp-cellmetabolism.bsky.social. HakanK and I recorded from AgRP neurons continuously for 1 month and found some exciting things during ad lib feeding, fasting and on circadian timescales www.cell.com/cell-metabol....

VGluT3 BNST neurons transmit GABA and restrict feeding without affecting rewarding or aversive processing https://www.biorxiv.org/content/10.1101/2025.01.01.631003v1

Dissociable control of motivation and reinforcement by distinct ventral striatal dopamine receptors - Nature Neuroscience Ventral striatal dopamine D3 and D1 receptors regulate motivation and reinforcement, respectively, through dissociable physiological actions.

www.nature.com/articles/s41...

Congrats to Juan and Hugo and the rest of the authors. Not sure if anyone is on bsky yet.

Expanding the bounds of a fear memory or linking it to a neutral memory can shape a mouse’s fear response, two new studies show.

By @claudia-lopez.bsky.social

www.thetransmitter.org/memory/stres...

A Prefrontal→Periaqueductal Gray Pathway Differentially Engages Autonomic, Hormonal, and Behavioral Features of the Stress-Coping Response The activation of autonomic and hypothalamo-pituitary-adrenal (HPA) systems occurs interdependently with behavioral adjustments under varying environmental demands. Nevertheless, laboratory rodent stu...

Cool project from my former lab! Final version out now. Congrats to first author Tim Skog! #neuroskyence #neuroscience

www.jneurosci.org/content/44/4...

I wonder what the collective drop of productivity is from people newly exploring Bluesky when they haven't been on social media at for a while.