Arsen Petrovic

Postdoc Research Group Schur The Schur lab at the Institute of Science and Technology Austria (ISTA) has an open postdoc position for a highly motivated candidate to be part of our ERC-funded project ActinID. Our Group ...

Open Postdoc position in our lab!
#actin #Huntingtin #cryoET #cellbio
If you enjoy working at the interface of cell biology, structural biology, and quantitative imaging, this could be an excellent fit.

ista.ac.at/en/job/postd...

Please share and feel free to reach out if there are questions!

Molecular requirements for PLK1 activation by T-loop phosphorylation - The EMBO Journal Activation of PLK1, a master mitotic kinase, requires phosphorylation of its activation segment on Thr210, within a basic consensus sequence for Aurora kinases. Aurora B-dependent phosphorylation of T...

Arianna Esposito Verza, @andrea-musacchio.bsky.social et al describe the long-sought-after mechanism of Bora dependency of PLK1 activation by Aurora A kinase during mitotic entry
Another #RefereedPreprint ℅ @reviewcommons.org
link.springer.com/article/10.1...

We are excited to share our new preprint which is now available to read on biorXiv: doi.org/10.64898/202... 🎉🎉🎉

Congrats 👏 Max!

The EU’s Horizon research fund needs to stay a defence-free zone It is time to sound the alarm as the EU’s research priorities face an unprecedented degree of political interference.

www.nature.com/articles/d41...

PhD Student – Structural Biology of Actin Filament Assemblies | Werken bij AVL

Are you excited to uncover the molecular mechanisms of actin filament assemblies that drive cell migration using cryo-EM?

Only 1.5 week to apply for this exciting PhD position in my newly established lab at the Netherlands Cancer Institute in Amsterdam: www.werkenbijavl.nl/vacatures/ph...

Icecream: High-Fidelity Equivariant Cryo-Electron Tomography Cryo-electron tomography (cryo-ET) visualizes 3D cellular architecture in near-native states. Recent deep-learning methods (CryoCARE, IsoNet, DeepDeWedge, CryoLithe) improve denoising and artifact cor...

Our colleagues Vinith Kishore and Valentin Debarnot from the @ivandokmanic.bsky.social lab have come up with an amazing deep learning tool for denoising and filling the missing wedge in #cryoET data. I'm pleased to introduce Icecream🍧

Hey #TeamTomo …would you like to try some 🍦ICECREAM!? Our @unibas.ch colleagues over at the @ivandokmanic.bsky.social lab have developed a stunningly effective tool to de-noise and de-wedge your tomograms. The contrast and details will give you brain freeze! 🍨❄️🤯

Please try, we need feedback 🧪🧶🧬🔬

✨Excited that the main project of my PhD is now available as a pre-print on #bioRxiv

Here, we used #CryoET to visualise mitochondrial proteostatic stress and together with SPA #CryoEM shed light into the functional cycle of the Hsp60:10 chaperone system. #TeamTomo

🔗 www.biorxiv.org/content/10.1...

Biochemical reconstitution of sister chromatid cohesion establishment during DNA replication Genome inheritance during cell divisions relies on replicated sister DNAs being connected by cohesin rings. Minamino et al. reconstitute sister chromatid cohesion establishment during DNA replication using purified budding yeast proteins. The experiments yield molecular insight into more than one way in which sister chromatid cohesion can be built.

Biochemical reconstitution of sister chromatid cohesion establishment during DNA replication

Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism.
www.nature.com/articles/s41...

Leopard-EM: An extensible 2DTM package to accelerate in situ structural biology The ability to generate high-resolution views of cells with cryogenic electron microscopy (cryo-EM) can reveal the molecular mechanisms of biological processes in their native cellular context. The re...

First pre-print from the Lucas Lab led by Matthew Giammar and @joshdcryoem.bsky.social online today! We develop a new, extensible Python implementation of 2DTM and apply it to build pixel size optimization, constrained search and characterize molecular motions in situ www.biorxiv.org/content/10.1...

George M. Sheldrick (1942–2025) In memory of George Sheldrick.

A tribute to George Sheldrick and SHELX and the impact on macromolecular and small-molecule crystallography

journals.iucr.org/a/issues/202...

Interactions with multiple inner #kinetochore proteins determine mitotic localization of FACT, say Julia Schweighofer, Bhagyashree Mulay, Andrea Musacchio (@andrea-musacchio.bsky.social) and colleagues: rupress.org/jcb/article/...

#Mitosis

Congrats Ben and colleagues!!Fantastic work 👏 🙌

Great job Florent and colleagues!Congrats 👏

For #teamtomo, context is everything.

We highlight the power of #surfacemorphometrics in guiding STA and quantitatively assessing the impact of these structures on the local environment.

1st collab paper w/ @zidlab.bsky.social (hopefully many more to come!)

@tomo.science @hamid13r.bsky.social

Subtomogram Averaging of a mitochondrially co-translating ribosome

Happy to share that the final version of record for our (
@nanigrotjahn.bsky.social) #teamtomo mitochondrial cotranslation story is online at @jcb.org! We combined STA with surface morphometrics to learn how ribosomes bind to and alter mitochondrial membranes in yeast.

rupress.org/jcb/article/...

Optical #nanoscopy without “ON/OFF” – Stefan Hell, @thomas-hensel.bsky.social, and co-workers have increased the resolution in fluorescence #microscopy 🔬 by a factor of 30 without having to sequentially switch fluorescent molecules between light & dark states. ⬇️
www.mpinat.mpg.de/4938925/pr_2...

Remembering Professor Béla Novák 1956 - 2025 With great sadness, we announce the loss of Professor Béla Novák.

Still hard to believe but Béla Novák died suddenly on Saturday.

We've lost a fantastic colleague, mentor & great friend to many. There was really no-one else like him. Working with him was so much fun & I owe him a lot. All my thoughts are with his family.

www.merton.ox.ac.uk/news/remembe...

Today Jan Drenth would have been 100 years, but sadly he passed away last week.
He was the founding father of structural biology in the Netherlands and his modesty, his gentle humor and his generosity set the spirit for the amazing environment in Groningen where i did my PhD.

Improvements in LM (top) and EM (bottom) of our micro-sam model (finetuned) compared to the default SAM model.

After a long journey, Segment Anything for Microscopy is now published in Nature Methods! We significantly improve SAM for interactive and automatic segmentation in light and electron microscopy and build a user-friendly tool.
www.nature.com/articles/s41...

Two images from the PubPeer thread at https://pubpeer.com/publications/F7C42C356B2E7049FDB68A434EF4F8. They both show fluorescent microscopy photos with a black background, and cellular structures in fluorescent green, red, and blue. Pubpeer users (including myself) have marked these panels with colored rectangles, to highlight repetitive features, suggesting photos were digitally altered.

Retraction of a paper from the lab of a Stanford Nobel Prize winner.
The PI dismissed our combined concerns as 'micro-duplications that are typical image processing artifacts'.
But after consulting with an 'image analysis expert', the authors retracted the paper.
pubpeer.com/publications...

Fantastic news Sven!Wishing you a success in your new journey 👏

Sven Klumpe to start cryo-Electron Tomography lab at IMP and IMBA The Vienna BioCenter institutes IMP and IMBA will soon host a joint research group headed by Sven Klumpe. The structural biologist will join the two institutes with an innovative double-affiliation to...

We will soon welcome @svenklumpe.bsky.social to the Vienna BioCenter, where he will use cryo-Electron Tomography to study - among other things - how #transposons shape #germlines. Sven's lab will be @imbavienna.bsky.social *AND* the IMP.

Full story: www.viennabiocenter.org/about/news/s...

In a great collaboration with @hummerlab.bsky.social and the Kräusslich lab: HIV capsid doesn't break at the NPC; instead, it cracks open the NPC itself! Details in Cell: authors.elsevier.com/sd/article/S... @mpibp.bsky.social @uniheidelberg.bsky.social A thread below:

Funding overhaul threatens historic U.K. research units Scientists protest new “challenge-led” grants replacing funding that supported long-term basic research

Double whammy: Wellcome Centres are no more & MRC Units are on their last funding cycle. Huge blow to science in cities other than Cambridge-Oxford-London which continue to have well-funded institutes with excellent infrastructure (Crick, LMB etc). The rest of us…?

www.science.org/content/arti...

Congratulations!!

SPACEtomo v1.2 is online! github.com/eisfabian/SP...

- Improved GUIs for lamella detection, target selection and CLEM registration make it the best target selection workflow for PACEtomo on any kind of lamella sample.
- Easier installation and configuration

Any feedback is much appreciated! :)

A ‘Second Tree of Life’ Could Wreak Havoc, Scientists Warn (Gift Article) Research on so-called mirror cells, which defy fundamental properties of living organisms, should be prohibited as too dangerous, biologists said.

Shareable link to @carlzimmer.bsky.social article in NYTimes on serious concerns over mirror bacteria, published in Science today.

www.nytimes.com/2024/12/12/s...