Dr. Sarah Signor 's Avatar

Dr. Sarah Signor

@signor-molevol

Assistant professor at NDSU. I love all things Drosophila & TEs & Gene regulation. Mostly bioinformatics but you'll find me with a pipette.

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07.08.2023
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Latest posts by Dr. Sarah Signor @signor-molevol

The TE workshop at #dros26 last night was fantastic! Great networking and talks. Thanks @levine-lab.bsky.social @mobilepurin.bsky.social and Chris Ellison

07.03.2026 15:32 ๐Ÿ‘ 6 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

Looking forward to Carolus Chan speaking this morning on transposon silencing in the nasuta group ##dros26

07.03.2026 15:06 ๐Ÿ‘ 1 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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2 Clicks from #Chicago โ€”
The Signor Lab Science Gang ( #DROS26 Edition)

07.03.2026 04:49 ๐Ÿ‘ 1 ๐Ÿ” 1 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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So grateful for the chance to share my research on the horizontal transfer of TEs at #dros26

07.03.2026 04:32 ๐Ÿ‘ 28 ๐Ÿ” 2 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

Slamming coffee and gummy worms to stay awake for this incredible TE workshop #dros26

07.03.2026 02:41 ๐Ÿ‘ 4 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Hear ye! Hear ye! Fresh findings from the halls of science! โ€” I am at the poster session, presenting my work! #DROS26 #GSA #Chicago

05.03.2026 19:58 ๐Ÿ‘ 6 ๐Ÿ” 2 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

What happens if the germline goes on without (most of the) piRNAs for 45 generations?

Come find out at my talk at the evolution session on Saturday at #dros26 @genetics-gsa.bsky.social

๐Ÿชฐ๐Ÿ”ฌ๐Ÿ”Žโ‰๏ธ๐Ÿค”

04.03.2026 14:45 ๐Ÿ‘ 35 ๐Ÿ” 10 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 1
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Say hello to Dr. Pritam, the first student to defend in the Signor lab! @shashankpritam.bsky.social

24.02.2026 23:12 ๐Ÿ‘ 8 ๐Ÿ” 2 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Raymond Huey is giving an incredible rundown on the effect of elevation on human physiology for Darwin day @ndsu-biosci.bsky.social

20.02.2026 22:33 ๐Ÿ‘ 4 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Birthdays, tenure, manuscripts, graduations. It's a good time in the Signor lab!

18.02.2026 17:04 ๐Ÿ‘ 10 ๐Ÿ” 1 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0

You can call me Dr. Associate Professor (tenure)

10.02.2026 00:49 ๐Ÿ‘ 64 ๐Ÿ” 2 ๐Ÿ’ฌ 8 ๐Ÿ“Œ 0
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It was my daughter's 7th birthday yesterday and LOOK AT THIS CAKE

02.02.2026 18:55 ๐Ÿ‘ 9 ๐Ÿ” 0 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0

@5calls.org just do anything do something just call

26.01.2026 19:09 ๐Ÿ‘ 1 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

Welcome

23.01.2026 19:53 ๐Ÿ‘ 1 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

Rapid evolution and comparative analysis of piRNA clusters in D.simulans https://www.biorxiv.org/content/10.64898/2026.01.19.700409v1

20.01.2026 16:31 ๐Ÿ‘ 7 ๐Ÿ” 3 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

There's so much variation! That's stable over generations!

20.01.2026 16:37 ๐Ÿ‘ 2 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
Rapid evolution and comparative analysis of piRNA clusters in D.simulans Eukaryotic genomes are ubiquitously occupied by mobile genetic elements termed transposons, which are silenced via a specialized class of small RNA called piRNA. The small RNA is produced from the transposons themselves when they occupy specialized regions of the genome termed piRNA clusters. The formation of these specialized regions, or their evolution over time, is not well understood. Recent work has suggested that they are extremely variable even within a single species such as Drosophila melanogaster. We were interested in taking a comparative approach to piRNA cluster evolution to ask the question - what processes are unique to D.melanogaster and which are shared? Shared phenomena are more likely to be fundamental aspects of piRNA formation and evolution compared to those that are more labile. Using five high-quality long-read genome assemblies and five genotype-specific piRNA libraries, we approach this question from a population genetics standpoint. We annotate piRNA clusters, transposons, and structural variants in each of these five genomes. We found extensive variation in piRNA clusters across strains, with smaller piRNA clusters more likely to be limited to a single genotype. By and large, our results are consistent with a model of piRNA cluster evolution in which piRNA clusters are rapidly formed and lost, with a small subset increasing in frequency and length over time. However, we find that the TEs which nucleate the formation of small piRNA clusters are entirely distinct in D.simulans compared to D.melanogaster, and likely reflect its invasion history rather than any inherent property of the transposon to nucleate clusters. Therefore, while large common clusters can act as 'traps' as has been posited for piRNA clusters, there are also numerous small clusters that are born and lost rapidly within a species. ### Competing Interest Statement The authors have declared no competing interest. National Science Foundation, NSF-EPSCoR-1826834, NSF-EPSCoR-2032756 National Institutes of Health, R35GM155272

If you need a little distraction from the world @prakashnarayanan.bsky.social first paper is out investigating the evolution of piRNA clusters in Drosophila simulans! Also with @kerogens101.bsky.social www.biorxiv.org/content/10.6...

20.01.2026 16:36 ๐Ÿ‘ 6 ๐Ÿ” 6 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0
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Evolution of Plasticity in Response to Ethanol Between Recently Separated Populations of D. melanogaster With Different Ecological Histories We identified: (1) differences in gene expression among each locale; (2) changes in gene expression in response to treatment; (3) genotype-specific changes in gene expression in response to treatment

So often you can find a story to tell in RNAseq data, but how real is it really? Here we independently replicated evolution by genetic accommodation in D. melanogaster!!! Congrats George!!
onlinelibrary.wiley.com/doi/10.1002/...

05.01.2026 17:23 ๐Ÿ‘ 8 ๐Ÿ” 3 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

This story is absolutely wild. Did you know that avocados change sex over the course of a day? And that it's controlled by a single ancient balanced polymorphism? This is flat our crazy

25.12.2025 06:33 ๐Ÿ‘ 212 ๐Ÿ” 78 ๐Ÿ’ฌ 5 ๐Ÿ“Œ 9
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Genesee didn't have fly socks at the last Drosophila conference and honestly it's a tragedy

22.12.2025 16:52 ๐Ÿ‘ 1 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Watch this tiny robot somersault through the air like an insect Device weighing less than a paperclip is faster and more agile than its predecessors

Drosophila.
- "To accurately replicate insect flight, during which the robot must instantly respond to slight changes in airflow and friction, the team designed a controller that was enhanced by a neural network that mimics the central nervous system of a FRUT FLY".

www.science.org/content/arti...

05.12.2025 07:47 ๐Ÿ‘ 4 ๐Ÿ” 4 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 1
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Caturday

22.11.2025 13:17 ๐Ÿ‘ 4 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

The autoclave is next to my office and it beeps when it's done until you go open it ๐Ÿ˜…

19.11.2025 23:54 ๐Ÿ‘ 2 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

When I was a grad student the government paid me to go to Taiwan and try to start collaborating.

14.11.2025 17:27 ๐Ÿ‘ 4 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Last night in North Dakota

12.11.2025 17:44 ๐Ÿ‘ 7 ๐Ÿ” 3 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

My lab at Indiana University is searching for a *postdoc* and *technician* to contribute to our work studying the evolution of social behavior using fruit flies as a model system. Details below, feel free to email me with any questions! More info on our research: saltzlab.com

05.11.2025 16:56 ๐Ÿ‘ 50 ๐Ÿ” 79 ๐Ÿ’ฌ 3 ๐Ÿ“Œ 2

Machine learning, genomics. He's very good with Rust

03.11.2025 17:11 ๐Ÿ‘ 1 ๐Ÿ” 0 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0

Best conference for a computational guy looking for an industry job? I can only think of PAG

03.11.2025 16:47 ๐Ÿ‘ 0 ๐Ÿ” 1 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0

Hydei?

02.11.2025 22:59 ๐Ÿ‘ 0 ๐Ÿ” 0 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0
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Mystery flies

02.11.2025 22:55 ๐Ÿ‘ 4 ๐Ÿ” 0 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0