Proud to share our latest findings: A nutrient-hormone axis pivots an energy trade-off between resting thermogenesis and movement expenditure
www.sciencedirect.com/science/arti...
More than 60% of Australian medical researchers left active research roles between 2019 & 2024 because they could not make ends meet - while my costings from the PBO suggest the govt could more than double annual spending from the MRFF without any effect on its base level of funding.
Daylight Savings Time sucks and should be abolished.
www.washingtonpost.com/wellness/int...
(Left) GF mice present defects in follicle organization. PAS-stained sections of follicles from ConvR and GF mice show severe effects on the theca (Th) organization and disorganization of some follicles in their granulosa (Gr) in GF animals. (Right) Statistical overrepresentation of gene markers for fetal germ cells to oocyte development indicate defects in oocytes of GF mice determined by RNA-Seq.
doi.org/10.1016/j.cm...
Congrats! That is a great paper. It further strengthens the link between the gut microbiota and ovarian biology and aligns well with our published findings, which showed changes in histology and the transcriptome of the ovaries in germ-free mice.
(Left) GF mice present defects in follicle organization. PAS-stained sections of follicles from ConvR and GF mice show severe effects on the theca (Th) organization and disorganization of some follicles in their granulosa (Gr) in GF animals. (Right) Statistical overrepresentation of gene markers for fetal germ cells to oocyte development indicate defects in oocytes of GF mice determined by RNA-Seq.
www.nature.com/articles/s43...
Great paper further strengthening the link between the gut microbiota and ovarian biology. This aligns with our published findings, which showed histological changes and transcriptomic alterations in the ovaries of germ-free mice. doi.org/10.1016/j.cm...
Very happy to see this work published!
The result of 10 years of research across Switzerland, Australia and Denmark!
#Circadian #chronobiology
@melweger.bsky.social @benweger.bsky.social @danielmauvoisin.bsky.social @robparton.bsky.social @benschulz.bsky.social
www.nature.com/articles/s42...
Huge thanks to everybody involved including @fgachon.bsky.social @melweger.bsky.social @robparton.bsky.social @benschulz.bsky.social @danielmauvoisin.bsky.social but many more (i.e., those not on Bluesky)!
9/9 Altogether, our work adds a new layer to how glycogen metabolism times liver function, with implications for metabolic disease.
8/9 Why might this be important? In obesity, circulating protein and ER stress rhythms are flattened. Furthermore, genetic variants in glycogen metabolism and glycosylation genes correlate with altered blood protein levels in humans.
7/9 To test causality, we blocked liver glycogen breakdown using CP-91149. Inhibiting glycogenolysis reduced protein glycosylation, triggered ER stress, and reduced protein secretion.
6/9 What drives this rhythm? Glycogen. It’s one of the most rhythmic liver metabolites. Glycogenolysis converts it into highly rhythmic UDP-sugars, which serve as substrates for protein N-glycosylation. 🍬
5/9 These observations are supported by the liver's ultrastructure. We found striking temporal dynamics: ER volume peaks during the day in the liver, while the Golgi apparatus is almost exclusively detectable at night. 🔬
4/9 Using microsomal proteomics, we found the liver's early secretory pathway (ER and Golgi) is temporally compartmentalised. ER-resident chaperones and Golgi matrix proteins peak at different times, coinciding with daily waves of protein N-glycosylation.
3/9 Strikingly, these rhythms disappear when calories are spread evenly across the day (hourly sipping a nutritionally balanced solution). This raised a key question: are blood protein rhythms driven by rhythmic secretion from the liver itself?
2/9 The liver has many jobs, including making key blood proteins. We used to think this happened continuously, but our work shows that many circulating proteins follow clear daily rhythms.
Our study is out today 🎉 in @natmetabolism.nature.com. The liver doesn’t secrete proteins nonstop; it follows a daily rhythm. Meal timing controls liver protein release via glycogen metabolism, and disrupted eating blunts these rhythms. A 🧵 ...
Springer Nature Link Journal of Clinical Sleep Medicine The effect of standard time to daylight-saving clock transition on sleep and migraine headaches Original Article Published: 20 January 2026 Volume 22, article number 18, (2026) Journal of Clinical Sleep Medicine Sasikanth Gorantla, Abhilash Velaga, Ashwath Ravisankar, Hrachya Nersesyan, Krishna M. Sundar & Karin G. Johnson
📒 NEW STUDY finds “Adults with episodic migraine experienced more migraine days and reduced deep sleep after spring Standard Time–to–Daylight Saving Time transition.”
A new excellent and fascinating work by Samer's team!
This rewrites the mechanism of photoentrainment in mouse
rdcu.be/eX8me
@ginaravenscroft.bsky.social & #NARF are collecting impact statements from Australian researchers
‘ Please consider sharing your story about the impact of Australia's chronic underfunding of science and biomedical research.’
lnkd.in/g8A_PAZG
1/
Aussies, please consider signing this petition to show your support for Australian science. The sector is already on its knees. 🇦🇺 🧪 actionnetwork.org/petitions/cs...
The next Early–Mid Career #Hepatology Research Forum is taking place on Tuesday, June 17, 2025 at 7:15 A.M. in the Level 3 Auditorium, QIMR Berghofer.
🌟 An inspiring afternoon with Prof. Nathan Palpant, Prof. Denise Doolan, and Prof. Loïc YENGO discussing leadership in research!
💡 We explored how leadership shapes EMCR career development, fosters collaboration, and builds strong research teams.
#EMCR #leadership #UQ #postdoc #research
Delighted to share this new review article discussing the potential bidirectional communication between the liver and the central circadian clock.
The systemic relationship is likely more complex than we thought!
rdcu.be/egZWQ
THANK YOU! We’re thrilled to share that our recent International Women’s Day Bake Sale raised $340 in support of Dress for Success, helping unemployed and underemployed women achieve economic independence.
Introducing 2025 EMCRA Committee Member - Johanna Richter!
@hannahritchie.bsky.social
😀 What is your role in EMCRA?
Social Events Coordinator ☕
🤓 What is your research about?
Group A Streptococcus Vaccine Development 💉
Introducing 2025 EMCRA Committee Member - Sugarniya Subramaniam!
😀 What is your role in EMCRA?
EMCRA Retreat Coordinator 🏖️
Introducing 2025 EMCRA Committee Member - Steven Hancock!
😀 What is your role in EMCRA?
Treasurer💰
🤓 What is your research about?
I am a molecular microbiologist by training. Currently, I work on the understanding biochemistry of Streptococcus pyogenes virulence factors and vaccine development💉 🦠
Time change season is here! While most Australian states fall back from DST, QLD, WA & NT don't practice it. @benweger.bsky.social and I break down why this might be a win in our latest piece for The Conversation. ⏰☀️ @emcra-imb.bsky.social
theconversation.com/daylight-sav...
Fremantle Chamber chief Chrissie Maus says DST forces teams to adapt - starting earlier, shifting schedules, and tweaking operations just to stay in sync. - This real concern shows why ditching DST is the simple fix we need. Here’s why rebrand.ly/o4sa8np.
