Yessenia M.C

‘RAMmageddon’ hits labs: AI-driven memory shortage is impacting science The soaring cost and limited supply of computer memory is slowing some projects — and spurring creative approaches.

The shortage of random access memory chips, which has caused prices to soar, has pushed some scientists to revisit how they do their work.

go.nature.com/4rtUkhm

🎉 Great news! Our paper is now published in @naturecomm
We identify a specific astrocyte ensemble that mediates THC-induced cognitive impairments during adolescence
Huge thanks to our collaborators @marsicanolab @khakhlab @grandeslab
🔗 rdcu.be/eY0Or
@jsromero.bsky.social @crismonteagudo.bsky.social

Senescent astrocytes discovered in Alzheimer's brains point to new treatment targets Researchers from the NeuroAD group (Neuropathology of Alzheimer's Disease) within the Department of Cell Biology, Genetics and Physiology at the University of Málaga, also affiliated with IBIMA–BIONAND Platform and CIBERNED, have made a pioneering breakthrough in the fight against this disease by identifying astrocytes as a promising cellular target for the development of future therapies.

Senescent astrocytes have been identified in Alzheimer's brains, highlighting cellular aging as a key mechanism in neurodegeneration and suggesting new therapeutic targets for intervention. doi.org/hbpkzb

A close-up image of white ume flowers with yellow stamens, softly blurred in the background.

#photography #unedited

A close-up of delicate white Ume flowers blooming on thin branches against a soft, light background.

#photography #unedited

A sliver of a moon in an orange sky. A lone silhouette of a tree on a mountain.

Good morning from the moon...

The night sky framed by the silhouettes of trees with stars showing, the constellation the Big Dipper is visible in the center top

Crystal clear

Moon with a Gaussian blur

Don’t forget to look up

Interested in how cortex and striatum contribute to trained vs spontaneous behavior??

If you're at #sfn25, check out @braininspired.bsky.social talk Sunday at 1

#neuroskyence

Excited to share insights of spinal circuit architecture at #SfN25! Big thanks to the @lifecanvastech.bsky.social team—Chris Tsang, Leah Chesnut, Brenna Fearey, and Zachary Woods—and the VCU Imaging Core's Dr. Tytus Bernas and Terry Smith for their excellent technical support. 🔬
#Neuroscience #SfN

Close up photo of the Moon at about 95% full

Here's how the #Moon looks tonight from #SantaBarbara at about 95% full.
#MoonPhotography #MoonPhotos #MoonShots #Photography

Camera settings:
Canon T5i
Sigma 150mm x 600mm
Focal length: 600mm
F-stop: f/10
Exposure time: 1/640
ISO: 800

Glia feed neurons upon starvation: our 2022 Nature Metabolism paper revealed a glia-to-neuron ketone body shuttle 💪
#Memories #EnergyMetabolism #Glia @naturemetabolism.bsky.social ky.social

www.nature.com/articles/s42...

Image from the MIT Picower article, "MIT invents human brain model with six major cell types to enable personalized disease research, drug discovery" with the following caption: “Cyan staining shows each of the six major cell types [pericytes, astrocytes, endothelial cells, neurons, oligodendrocytes, and microglia] integrated in a miBrain culture.” The original image appeared in Figure 1 of the PNAS article, “Engineered 3D immuno-glial-neurovascular human miBrain model” (10.1073/pnas.2511596122) by Stanton et al.

This new miBrain model from MIT has it all:

🧠 Neurons, microglia, oligodendroglia, astrocytes, pericytes, & brain microvascular endothelial cells
⚙️ Key features & functions of the human brain
👩‍👦 Specificity to individual donors
🧬 Customizability via gene editing
📈 Scalability for large projects

Super cute mouse illustrations 😄

Top: Shohei Ohtani, Roki Sasaki and Yoshinobu Yamamoto pose for a photo on the field during the Tokyo Series. They wear home white Dodgers uniforms with blue and red lettering. Bottom: Shohei Ohtani, Roki Sasaki and Yoshinobu Yamamoto pose for a photo with the World Series trophy in the clubhouse after winning the World Series.

The start
The finish
The #CHAMPS

Drug‐Related Engrams and Their Role in the Persistence and Recurrence of Drug‐Related Behaviors Memory is a cornerstone of human behavior, and addiction offers a compelling model of its persistence and plasticity. The scope of engram research has rapidly expanded to include addiction-related ph....

First lab paper out today! Student authors: Mikayla Cutler and Abhi Thati 🎉🤩

Hippocampus | Neuroscience Journal | Wiley Online Library onlinelibrary.wiley.com/doi/10.1002/...

Hippocampal transformations occur along dimensions of memory interference The role of the hippocampus in resolving memory interference has been greatly elucidated by considering the relationship between the similarity of visual stimuli (input) and corresponding similarity o...

🧠🚨 How does the hippocampus transform the visual similarity space to resolve memory interference?

In this new preprint, we found that the hippocampus sequentially inverts the behaviorally relevant dimensions of similarity 🧵

www.biorxiv.org/content/10.1...

Rapid amyloid-β clearance and cognitive recovery through multivalent modulation of blood–brain barrier transport - Signal Transduction and Targeted Therapy Signal Transduction and Targeted Therapy - Rapid amyloid-β clearance and cognitive recovery through multivalent modulation of blood–brain barrier transport

🧠 Alzheimer’s reversed in mice

A new study found that injecting nanoparticles can 'remind' the blood–brain barrier to function properly again, restoring normal brain activity in mice. Human trials could follow within years.

🔗 www.nature.com/articles/s41...

#SciComm #Alzheimers 🧪

Glucose-dependent insulinotropic polypeptide receptor signaling in oligodendrocytes increases the weight-loss action of GLP-1R agonism Hansford et al. show that GIPR, a target of new weight-loss drugs, is found in brain cells called oligodendrocytes. GIPR helps these drugs access the brain and boosts weight loss. Without GIPR in these cells, the drugs are less effective, revealing a new mechanism behind their action.

Online now: Glucose-dependent insulinotropic polypeptide receptor signaling in oligodendrocytes increases the weight-loss action of GLP-1R agonism

Neurogenomic Adaptations to Variable Environments,' happening Wednesday, August 20, from 12–1 p.m. EDT. Features logos of the Society for Neuroscience and The Kavli Foundation, with speaker photos and affiliations: Hans Hofmann (UT Austin), Kimberly Rosvall (Indiana University), and Alison Bell (University of Illinois).

Join SfN and @kavlifoundation.org‬ for an upcoming webinar that will explore how brains cope with changing environments. Hear from experts on recent advances in the field and get all of your questions answered related to neural adaptation.

Register now 🔗 vist.ly/32mnu

#neurosky

A bunny in a captain's hat with a star emblem lies on a reflective surface.

Astrocyte specification in the mouse septum is shaped by both developmental origin and local signals - Nature Neuroscience The relative contribution of intrinsic and extrinsic factors to astrocyte heterogeneity is unknown. Using heterotropic transplantation of septal astrocytes with distinct lineage origins, we show that ...

Astrocyte specification in the mouse septum is shaped by both developmental origin and local signals

www.nature.com/articles/s41...

Male Costa’s Hummingbird

Overcast skies? Find a hummingbird… male Costa’s 🪶☀️🌵

Monthly reminder: Many people have a book in them, but it takes a special kind of freak to leave the Land of Laziness, cross the Plains of Procrastination and Insecurity Mountain, find the Blade of No One Made You Do This, and use it to cut your chest open and yank that book out.

An artist’s rendition of the Voyager 1 spacecraft.

in late 2026, nearly 50 years after its launch, voyager 1 will be the first manmade object to reach a distance of one light day from the sun

A flyby of Earth from the International Space Station.

Credits: NASA

Dark red and white flowers of Hedge woundwort against a dark green background.

Day 15, #30DaysWild. A walk round Little Downham Nature Reserve and some beautiful Hedge woundwort in flower. #WildflowerHour

Formation of an expanding memory representation in the hippocampus - Nature Neuroscience Multiday imaging of CA1 neurons during learning reveals that the representation stabilizes as the number of readily retrievable, information-rich and stable place cells increases and suggests novel me...

Multiday imaging of CA1 neurons during learning reveals that the representation stabilizes as the number of readily retrievable, information-rich and stable place cells increases, and suggests novel mechanisms of hippocampal memory formation

www.nature.com/articles/s41...

Illustration of a brain designed as a clock, with highlighted areas and clock hands pointing at 7 and 2.

New results show that anterior cingulate cortex (ACC) neurons influence our perception of time.

So how can we use that knowledge to restructure our daily routines and reduce burnout?

#NeuroSky