Veronika Horn

The reductions in the number of new and competing renewal R01s by topic (based on simple searches in NIH Reporter).

The cuts are across the board: Cancer down 24%, Alzheimer down 45%, Obesity down 29%, Child by 21%.

Transgender was down by 84% but represents only a small number of grants.

Our work with Lena Takayasu and @dwmckellar.bsky.social in Iwijn De Vlaminck's lab is now out in @natmicrobiol.nature.com ! 🎉

Spatial transcriptomics maps host–gut microbiome biogeography at high resolution

rdcu.be/e7i7o

#SpatialTranscriptomics

Optimizing Xenium In Situ data utility by quality assessment & best-practice analysis workflows

Must-read for Xenium user🔥

👉Segmentation
👉Spatially variable feature selection
👉Imputation
👉Spatial domain identification

#NatMethods 2025
www.nature.com/articles/s41...

Peripheral immune-inducer dendritic cells drive early-life allergic inflammation - Nature Early-life exposure to allergens triggers a distinct local mode of dendritic cell activation in neonatal skin without requiring migration to lymph nodes, which shapes responses to allergens in later l...

The rules of immunity are different in early life! Lead author Dr. Yue Xing finds that early life DCs sense allergens and trigger inflammation directly in skin. This in-situ activation state emerges from a developing HPA and low glucocorticoids. #Naiklab @nature.com
www.nature.com/articles/s41...

Metabolic quiescence of naive-like memory T cells precedes and maintains antigen-specific T cell memory - Nature Immunology Schober and colleagues show that effector CD8+ T cells undergo metabolic shutdown, CD8+ central memory T cells are the most metabolically active, and naive-like memory T cells are quiescent during the...

New work from our lab, hot off the press in Nature Immunology (@natureportfolio.nature.com)!

How do human T cell responses diversify — and how does this lead to durable protection after vaccination?

Paper: www.nature.com/articles/s41...

Press release: www.fau.eu/2026/02/news...

1/6

NATIONAL DAY of ACTION Take back our science, health, and democracy! Join us MARCH 7TH, 2026 NEW YORK CITY, NY and nationwide! Register, volunteer, and donate! standupforscience.net/march7

NEW YORK CITY! Join your local March 7th rally to take back our science! Learn more at standupforscience.net/march7

#rally
#March7
#ImpeachRFKJr
#science
#standupforscience

a pink calendar shows the date of february 14 ALT: a pink calendar shows the date of february 14

I accept you with minor revisions.

Ulcerative colitis induces stem- and effector-like γδ T cell subsets influencing therapeutic response @sciimmunology.bsky.social
www.science.org/doi/10.1126/...

2/
Bioinformatics isn't just data processing.
It’s not: “Load → Analyze → Publish.”
It’s exploration, interpretation, ITERATION.
It’s art.

Allergy at AIC, part 2 - Mucosal Immunology Podcast | iHeart <p>This episode includes more discussions from the Autumn Immunology 2025 Conference 2025 conference. KathrynKnoop sits down with Drs.  Caroline Sokol and Stephanie Eisenbarth to discuss food and skin...

This #MucosalMonday @bainlab.bsky.social and @lizihegarty.bsky.social are in the Authors Corner discussing their recent #macrophage work from MI. Then @kknoop.bsky.social brings you more allergy and anaphylaxis with Caroline Sokol and @stephanieeisen.bsky.social:
www.iheart.com/podcast/269-...

Maybe we’ll end up calling them DC-like ILC3s…

In vivo detection of immune responses via cytokine activity labeling Cytokine receptor dimerization, induced by the binding of cytokines, can be converted into a genetically traceable fluorescent signal and engineered into reporter mouse lines to visualize processes in...

Tools
'To address this knowledge gap, we developed “cytokine cellular locating platforms” (CyCLoPs), a reporter system that translates cytokine receptor engagement into a genetically traceable signal.'
#Immunology
www.cell.com/cell/abstrac...

279 postdoctoral fellowships!

Download freely our database of postdoctoral fellowships and grants. For each entry, we provide eligibility criteria, $ amount, deadline, etc.

Good luck!

Here: research.jhu.edu/rdt/funding-...

2026 is here! We’re excited to share Global Immunotalks first semester poster, featuring an outstanding lineup!

Please share and help us spread the word!

Here's a summary of all the data that supports adding more red meat to your diet

Neuro-epithelial circuits promote sensory convergence and intestinal immunity - Nature Specific pain-sensing nociceptors and chemosensory tuft cells form a circuit to promote type 2 immune responses in the intestine.

Nature research paper: Neuro-epithelial circuits promote sensory convergence and intestinal immunity

go.nature.com/4qeRjlt

Colonic macrophage heterogeneity revealed by CD11c and CD163 www.mucosalimmunology.org/article/S193...

Re-submitting the paper to other journals

Molecular, Cellular, Tissue, and Organismal Functions of Type III Interferons Type III interferons are essential immune mediators playing pleiotropic roles during health and disease. In this review, we highlight the molecular and cellular pathways that lead to the production of...

💥New paper alert!💥 What’s better than starting 2026 with an @annualreviews.bsky.social #Immunology, often a once-in-a-life honor ❤️?! Check it out if you want to know everything about type III interferons #IFN! Thanks to my wonderful team for their amazing work 🤗 doi.org/10.1146/annu...

Cross-presentation of dead cell-associated antigens shapes the neoantigenic landscape of tumor immunity - Nature Immunology Here the authors show DNGR-1 expressed by cDC1s promotes CD8⁺ T cell priming to cytoskeletal neoantigens from dying tumor cells, thereby shaping cancer immune visibility and tumor evolution through im...

@drjonlim.bsky.social & @reisesousalab.bsky.social show cDC1s & DNGR1 favor "tethered" neoantigens from F-actin proteins, trapping them in necrotic debris for better cross-presentation! Calls for prioritizing these neoantigens for cancer vaccine design #Immunotherapy www.nature.com/articles/s41...

On the use of murine models: Results should be interpreted with caution. Batf3-deficient mice have been traditionally used as a model to study the function of cDC1; however, this transcription factor seems to play other essential roles in other immune populations👇

Just quit Quitting projects in science is hard, but we should be doing a lot more of it.

Blog post: Just quit
Quitting projects in science is hard, but we should be doing a lot more of it.

open.substack.com/pub/arjunraj...

Gut microbiota promotes immune tolerance at the maternal-fetal interface Microbiota-dependent tryptophan-derived indole deficiency is linked to mouse fetal resorption and human recurrent miscarriage. Tryptophan-derived indoles prime MDSCs and RORγt+ Tregs to suppress IFN-γ+ or IL-17A+ T cells at the maternal-fetal interface, respectively, thereby promoting maternal-fetal immune tolerance.

Now online! Gut microbiota promotes immune tolerance at the maternal-fetal interface

We wrote two reviews on cell migration, published today in Nature Methods.

They provides practical guidelines how to select a cell-migration assay and how to analyze cell-migration data

Review 1: nature.com/articles/s41...

Review 2: nature.com/articles/s41...

The neutrophil collective Neutrophils are key immune cells that can acquire new traits across environments. This review covers their underlying biology and frames their organization as a two-compartment collective whose emerge...

The issue features The neutrophil collective, a Review focusing on both traditional properties of neutrophils and those that challenge existing dogmas.
www.cell.com/cell/fulltex...

Urs Mörbe, William Agace et al. characterize and spatially map the fibroblast landscape within human large and small intestinal gut-associated lymphoid tissues, including Peyer’s patches and isolated lymphoid follicles, during homeostasis and #Crohns disease. rupress.org/jem/article/...

#IBD

Have you heard about the Night Science Podcast, where we talk about the creative process of doing science? We explore this with discussions with brilliant scientists & philosophers and artists, to figure out the tricks of the creative scientific trade.
podcasts.apple.com/us/podcast/n...

Human gut M cells resemble dendritic cells and present gluten antigen @nature.com @hansclevers.bsky.social
www.nature.com/articles/s41...