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Steve Baker

@bakersm11

Pro Democracy, Anti MAGA, Anti Fascist, Anti Racist Retired research scientist (Biochemistry/Molecular Biology) involved in vaccine development for a safe and efficacious multicomponent S. aureus (MRSA) vaccine

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Latest posts by Steve Baker @bakersm11

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MAGA Epstein Files Phase 2.0
MAHA Rubio Rubella Florida Truth Decay
MASA Make America Stupid Again RFK Junior
MAGA Trump Rally Alter Reality TV

www.bloomberg.com/news/article...

11.03.2026 01:04 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Death Valley blanketed in wildflowers in best bloom since 2016 The California desert is seeing its most colourful display in a decade as flowers cover the region.

Wildflowers blanket Death Valley in best display since 2016. πŸ§ͺ www.bbc.co.uk/weather/arti...

10.03.2026 13:32 πŸ‘ 51 πŸ” 9 πŸ’¬ 0 πŸ“Œ 0
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Johan Elf, Professor at Uppsala University, former EMBO Young Investigator and EMBO Member since 2022, speaks with us about his work and the importance of EMBO to his #career. πŸ§ͺ

Continue reading:
https://www.embo.org/the-embo-communities/embo-communities-by-country/focus-on-sweden/

10.03.2026 13:35 πŸ‘ 6 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0
CaBLAM shows SNR comparable to GCaMP under epifluorescent illumination during in vivo mammalian imaging.

CaBLAM shows SNR comparable to GCaMP under epifluorescent illumination during in vivo mammalian imaging.

I see your inner light
That's pretty lit!

Bioluminescent sensor lets neurons light themselves from within enabling recordings of live brain activity

CaBLAM:
A high-contrast bioluminescent Ca2+ indicator derived from an engineered Oplophorus gracilirostris luciferaseπŸ§ͺ
www.nature.com/articles/s41...

10.03.2026 14:01 πŸ‘ 5 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
Plasma extracellular vesicles (EVs) increase during acute myocardial infarction (MI), correlate with myocardial injury, and mobilize immune cells from the spleen to the circulation. These cells are transcriptionally activated even before tissue recruitment, yet the mechanisms driving this priming are unclear. We show that plasma EVs isolated at hospital presentation with MI are enriched in miRNA-320b. Endothelial cells upregulate miRNA-320b in EVs following inflammatory stimulation. Target gene pathway analysis revealed enrichment in adhesion and cytokine signaling. Endothelial EVs promoted monocyte adhesion and induced IL6 and TNF mRNA expression in macrophages while dampening cytokine secretion. RNA-sequencing of MI patient neutrophils and monocytes confirmed significant enrichment of miRNA-320b targets. Peripheral blood mononuclear cells treated with MI plasma EVs showed similar gene regulation. These findings suggest that EV-mediated transfer of miRNA-320b primes immune cells for adhesion and cytokine signaling. Understanding this signaling axis may enable therapeutic immunomodulation of immune cells to improve repair following MI.

Plasma extracellular vesicles (EVs) increase during acute myocardial infarction (MI), correlate with myocardial injury, and mobilize immune cells from the spleen to the circulation. These cells are transcriptionally activated even before tissue recruitment, yet the mechanisms driving this priming are unclear. We show that plasma EVs isolated at hospital presentation with MI are enriched in miRNA-320b. Endothelial cells upregulate miRNA-320b in EVs following inflammatory stimulation. Target gene pathway analysis revealed enrichment in adhesion and cytokine signaling. Endothelial EVs promoted monocyte adhesion and induced IL6 and TNF mRNA expression in macrophages while dampening cytokine secretion. RNA-sequencing of MI patient neutrophils and monocytes confirmed significant enrichment of miRNA-320b targets. Peripheral blood mononuclear cells treated with MI plasma EVs showed similar gene regulation. These findings suggest that EV-mediated transfer of miRNA-320b primes immune cells for adhesion and cytokine signaling. Understanding this signaling axis may enable therapeutic immunomodulation of immune cells to improve repair following MI.

New paper with the Akbar Lab @ox.ac.uk: After a heart attack, microRNA-filled vesicles activate immune cells. This triggers inflammation, worsening tissue damage. Targeting these signals may limit injury and improve repair. doi.org/10.1016/j.is... πŸ§ͺπŸ«€πŸ§¬πŸ–₯️ #cardiosky #immunosky @cp-iscience.bsky.social

10.03.2026 14:02 πŸ‘ 6 πŸ” 4 πŸ’¬ 0 πŸ“Œ 0

hope it becomes a classic, just looking πŸ§ͺat the cover makes me want to start tying up a few artificial mayflies πŸͺΆπŸ¦ŸπŸŽ£πŸŒŠβ›°οΈ

11.03.2026 00:09 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
Page-spread diagram illustrating the life cycle of dragonflies in ponds.

Page-spread diagram illustrating the life cycle of dragonflies in ponds.

Available now: PONDS: An Illustrated Guide
yalebooks.yale.edu/book/9780300...
πŸ§ͺ🌿🌎πŸͺΆπŸ‘ #wildlife #scicomm #sciviz #scientificillustration #visualscicomm #sciviz #scicomm #ponds #lakes #freshwater

10.03.2026 14:16 πŸ‘ 19 πŸ” 3 πŸ’¬ 1 πŸ“Œ 1
The Common Ground Open Science March 20, 2026 Event Reservation

My team and I at @gothamdataclinic.org are co-hosting a symposium Friday, March 20th 12-5pm at City College.

It's called the Common Ground, Forging links between open
science and community.

We're bringing together scientists, educators, and community orgs.

πŸ§ͺ cc: @standupforscience.bsky.social

10.03.2026 14:51 πŸ‘ 7 πŸ” 5 πŸ’¬ 1 πŸ“Œ 0
The larger SUMO family.

The larger SUMO family.

Our new Essays in Biochemistry review frames the DNA double strand break repair as multifunctional molecular machinery, showing how flexible our repair systems safeguard genomes from damage and help shape better cancer therapies πŸ§ͺ https://doi.org/10.1042/EBC20253043

10.03.2026 15:02 πŸ‘ 6 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0

'They tried unsuccessfully to measure hydrogen production from gut microbes.. Frustrated, β€œwe took the sensor out of the chamber, and we were like, β€˜Screw it. We’re going to try to measure a fart.’” So Hall stuck the device down his own pants and let rip. β€œAnd the signal was enormous.”'
πŸ§ͺπŸ’¨ #fartnews

10.03.2026 15:14 πŸ‘ 6 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0
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These ants navigate with a newly discovered β€˜Moon compass’ Insects must perform tricky internal calculations to travel in a straight line

i'm back in @science.org reporting on a newly discovered "lunar compass" used by bull ants!

these ants return home from foraging trips by observing the arc of the moon and integrating it with their sense of timeβ€”the first animals known to do so πŸ§ͺ

learn more in the link below:

10.03.2026 15:18 πŸ‘ 41 πŸ” 16 πŸ’¬ 3 πŸ“Œ 2
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Opinion: A new role for chemists: Tackling toxic air in conflict zones As modern warfare weaponizes the very air we breathe, chemists should leverage their skills and knowledge to detect, neutralize, and reclaim toxic atmospheres in the world’s most devastated conflict z...

As modern warfare weaponizes the very air we breathe, chemists should leverage their skills and knowledge to detect, neutralize, and reclaim toxic atmospheres in the world’s most devastated conflict zones.

#chemsky πŸ§ͺ

10.03.2026 15:21 πŸ‘ 14 πŸ” 7 πŸ’¬ 1 πŸ“Œ 0
Assessment of the relationship between g scores and cortical modal control profiles calculated from regions in after excluding the bottom 25th percentile.

Assessment of the relationship between g scores and cortical modal control profiles calculated from regions in after excluding the bottom 25th percentile.

The network architecture of general intelligence in the human connectome πŸ§ͺ
www.nature.com/articles/s41...

These results support a shift in perspective from prevailing localist models to a theory that grounds intelligence in the global topology of the human connectome.

10.03.2026 16:00 πŸ‘ 1 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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Texas Mother Is Exonerated After 22 Years for a Crime That Never Happened - Innocence Project

Forensics: Crime. Texas Mother Is Exonerated After 22 Years for a Crime That Never Happened - Innocence Project. πŸ§ͺ

Texas Mother Is Exonerated After 22 Years for a Crime That Never Happened - Innocence Project
— Read on innocenceproject.org/news/carmen-mejia-exonerated-texas-22-years/

10.03.2026 16:07 πŸ‘ 7 πŸ” 1 πŸ’¬ 2 πŸ“Œ 0

Vaccines save lives.

That’s it. That’s the post.

10.03.2026 16:00 πŸ‘ 2563 πŸ” 671 πŸ’¬ 26 πŸ“Œ 8
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Ribosome transfer via tunnelling nanotubes rescues protein synthesis in pancreatic cancer cells - Cell Communication and Signaling Cell Communication and Signaling - Pancreatic ductal adenocarcinoma (PDAC) is considered as one of the deadliest types of cancer. Tunnelling nanotubes (TNTs) are thin, membranous, intercellular...

Our paper (with @stanam.bsky.social and others) reporting the discovery of intercellular ribosomal transport and it capacity to modulate protein synthesis in cancer cells is published! It was a bit of a journey to find a home for this so very happy it's out! πŸ§ͺ

10.03.2026 16:48 πŸ‘ 10 πŸ” 1 πŸ’¬ 1 πŸ“Œ 0
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GRAS update proposal coming this spring, says FDA food chemical safety chief β€˜No one knows’ how many food ingredients have been generally recognized as safe and introduced without FDA review, Mark Hartman says

The US Food and Drug Administration is proposing updates to how the agency reviews food ingredients entering and already in the marketplace.

#chemsky πŸ§ͺ

10.03.2026 17:08 πŸ‘ 5 πŸ” 2 πŸ’¬ 0 πŸ“Œ 1
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Promising breakthrough creates plastics that self-deconstruct on cue: Study Plastics have a gigantic built-in problem: They’re tenacious, which is very good for a milk jug or a car bumper. But they don’t easily break down, which is bad for the environment. From the 1950s, whe...

Plastic pollution is a global environmental crisis, but what if we could design plastics that automatically break down after use? πŸ§ͺ

My latest article for @mongabay.com looks at a recent study that used clever chemistry to do just that.

news.mongabay.com/2026/03/prom... #CircularEconomy #Plastics

10.03.2026 17:22 πŸ‘ 15 πŸ” 11 πŸ’¬ 0 πŸ“Œ 1
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Elites moved toward democrats more than nonelites moved away: Income, education, and occupational class in US presidential elections, 1980–2020 | PNAS Recent discussion of voting in US elections claims a strong movement of White working-class voters away from voting for Democrats, with much discus...

Elites moved toward democrats more than nonelites moved away: Income, education, and occupational class in US presidential elections, 1980–2020 | PNAS www.pnas.org/doi/10.1073/... πŸ§ͺ

10.03.2026 17:28 πŸ‘ 6 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0
PNAS Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

Neutralization of acyl-CoA-binding protein attenuates glucocorticoid-mediated suppression of cancer immunosurveillance | PNAS www.pnas.org/doi/10.1073/... πŸ§ͺ

10.03.2026 17:30 πŸ‘ 2 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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πŸŒŽπŸ¦‰πŸ§ͺ Meet one of the Bay Area’s most reliable voices of spring: the #SongSparrow. At Palomarin, these resident #birds can be heard year-round, but during nesting season, males sing to attract mates, maintain pair bonds, and defend territory. In the Bay Area, nesting can begin as early as February!

10.03.2026 18:05 πŸ‘ 12 πŸ” 4 πŸ’¬ 0 πŸ“Œ 0

A very cool example of how some key cellular proteins are evolving fast rather than slow as intuition might suggest! Look beyond model organisms and think broadly πŸ§ͺ

10.03.2026 18:32 πŸ‘ 6 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
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Celebrating Women in STEM: The Legacy of Elizabeth Roemer - Lowell Observatory Discover the incredible journey of Elizabeth Roemer, a pioneering female astronomer who recovered lost comets, made groundbreaking asteroid discoveries, and fought for gender equality in STEM.

Celebrating Women in STEM: the legacy of Elizabeth Roemer, a trailblazer in Astronomy

lowell.edu/celebrating-...

πŸ”­πŸ§ͺ

10.03.2026 19:03 πŸ‘ 22 πŸ” 12 πŸ’¬ 0 πŸ“Œ 0

The Version of Record of the new paper by Sai Ke et al. (2026) Organic Geochemistry is now online, so I re-up this paper tooβ€”with @arnaudhuguet.bsky.social as the last author! πŸ‘‡πŸ»
#brGDGTs
#3OHFattyAcids
#TeamBacteria
πŸ§ͺ βš’οΈ πŸ‘©β€πŸ”¬
Implications for #PaleoSky

10.03.2026 19:12 πŸ‘ 3 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0

πŸ‘‡ Working link:

Parietal alpha frequency shapes own-body perception by modulating the temporal integration of bodily signals πŸ§ͺ
www.nature.com/articles/s41...

10.03.2026 19:18 πŸ‘ 6 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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B lymphocytes that enter the germinal center late preferentially differentiate into memory cells that recognize subdominant epitopes Using a dual-recombinase fate-mapping system to trace late-entry invader B cells in germinal centers, Zhou et al. show that across vaccination and influenza infection, invaders preferentially generate...

B lymphocytes that enter the germinal center late preferentially differentiate into memory cells that recognize subdominant epitopes: Immunity www.cell.com/immunity/ful... πŸ§ͺ

10.03.2026 20:00 πŸ‘ 7 πŸ” 4 πŸ’¬ 0 πŸ“Œ 0

Thanks, hope I get a chance for a read. Maybe too early to ask if there are any quorum sensing ecological epigenetic factors similar to biofilms.

10.03.2026 23:07 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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MANE v1.5 Released! - NCBI Insights A new versionΒ (v1.5) ofΒ Matched Annotation from NCBI and EMBL-EBI (MANE) is now available. ThisΒ dataset,Β produced inΒ collaboration betweenΒ NCBIΒ and the European Molecular Biology Laboratory’s European...

From #NCBI Insight | A new version (v1.5) of Matched Annotation from NCBI and EMBL-EBI (MANE) | #Bioinformatics #Genomics #human #OpenScience #OpenAccess #OpenData | 🧬 πŸ–₯️ πŸ§ͺ CC/ @ebi.embl.org
⬇️
ncbiinsights.ncbi.nlm.nih.gov/2026/03/10/m...

10.03.2026 20:23 πŸ‘ 3 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
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Navigating Conflicting Vaccination Recommendations This Perspective discusses how clinicians can navigate conflicting vaccination recommendations following revisions from the Advisory Committee on Immunization Practices and US Centers for Disease Cont...

Nice article in JAMA on where we stand with (primarily) childhood vaccines due to the chaos created by RFK JR's CDC. It covers a number of practical topics. πŸ§ͺ
jamanetwork.com/journals/jam...

10.03.2026 20:23 πŸ‘ 8 πŸ” 6 πŸ’¬ 1 πŸ“Œ 0
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Meteorites scattered across a blue-ice moraine in Antarctica’s Miller Range.

They’re easier to find here because glaciers act like slow conveyor belts, carrying meteorites toward mountain ranges where wind strips away the snow and exposes the ice.

#astronomy

βš›οΈ πŸ§ͺ

Image: NASA

10.03.2026 20:30 πŸ‘ 35 πŸ” 8 πŸ’¬ 2 πŸ“Œ 0