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Ursula Hofer

@hoferu

Desk-chair virologist, EiC of The Lancet Infectious Diseases, previously at different Nature journals, MD PhD. She/her/expert. Opinions my own.

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Latest posts by Ursula Hofer @hoferu

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First-of-its-kind vaccine protects children from deadly intestinal infections ETVAX is the first vaccine that offers significant protection against pathogenic E. coli in children

ETVAX is the first vaccine that offers significant protection against pathogenic E. coli in children

10.03.2026 16:58 πŸ‘ 257 πŸ” 84 πŸ’¬ 7 πŸ“Œ 8
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Science stories for young readers

Lovely round up of science books for children by the editors at @science.org. As my kids get older, I'm going to have to confront the fact that I'm really getting the books for myself not for them.

www.science.org/doi/10.1126/...

09.03.2026 16:07 πŸ‘ 3 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0

It makes me happy to see papers transferred to sister or society journals. We get a lot of good papers that we can't keep for various reasons, not clinical enough, too early etc. I put a lot of effort into finding them a home -- today was a good day, 7 transfers of great papers to great journals.

10.03.2026 17:22 πŸ‘ 1 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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Pipeline of new drugs to fight superbugs is β€˜worryingly thin’, experts warn UK’s GSK is leading the way in research but AstraZeneca is not involved in the area, report finds * Business live – latest updates The pipeline of new drugs to fight superbugs remains β€œworryingly thin” and has shrunk by 35% in the last five years, experts have warned, predicting the annual number of deaths linked to drug-resistant infections globally will double to 8 million by 2050. The number of projects from large pharma companies has shrunk by 35% over the past five years, from 92 to 60 medicines in development, according to a report from the Access to Medicine Foundation (AMF), a Netherlands-based non-profit group, and the Wellcome Trust. Continue reading...

Pipeline of new drugs to fight superbugs is β€˜worryingly thin’, experts warn

10.03.2026 11:01 πŸ‘ 89 πŸ” 30 πŸ’¬ 4 πŸ“Œ 6
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From emergency to integration: research as the bridge in mpox control The lifting of the status of mpox as a Public Health Emergency of Continental Security (PHECS) is a major epidemiological and political milestone.1 However, this change in status should not be confuse...

A bumper crop of mpox content - 1 comment and 4 research articles πŸ‘‡

From emergency to integration: research as the bridge in mpox control

www.thelancet.com/journals/lan...

10.03.2026 11:54 πŸ‘ 2 πŸ” 3 πŸ’¬ 1 πŸ“Œ 0
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Infectious Disease Clinical Trial Award: Optimising interventions for impact - Funding | Wellcome Funding call supporting transdisciplinary teams led from Africa, South Asia or South-East Asia to conduct clinical trials that optimise licensed pharmaceutical interventions for infectious diseases.

New funding for infectious disease clinical trials! πŸ“£β€―

We’re funding randomised controlled trials to optimise existing vaccines and therapeutics for infectious diseases.

Delivered in partnership with @nihr.bsky.social and FCDO Research.

Learn more about eligibility and how to apply ‡️

10.03.2026 11:10 πŸ‘ 4 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0
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Abstract submissions for #GAMRIC2026 are now open!

We encourage submissions in: preclinical/clinical development, new antibacterial/antifungal classes, AMR diagnostics & epidemiology, vaccines, and many more!

Travel grants are available.

Learn more: https://ow.ly/i0Me50Yq7Fl

#IDSky #clinmicro

10.03.2026 09:00 πŸ‘ 1 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0

"Russian flu," the pandemic that hit in 1977, bears an evolutionary signature of having emerged from a lab, perhaps as part of a failed vaccine effort. Covid, mpox, Ebola, and other influenza pandemics don't. Here's my story on a new way to trace the origins of pandemics. Gift link: nyti.ms/46N0W33

09.03.2026 17:26 πŸ‘ 113 πŸ” 48 πŸ’¬ 2 πŸ“Œ 3
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β€˜No one quite like her’: meet the female colleagues who inspire these award-winning women in science To mark International Women’s Day, Nature asked winners of its awards programmes to nominate a colleague who brings out the best in them.

β€˜No one quite like her’: meet the female colleagues who inspire these award-winning women in science
To mark International Women’s Day, Nature asked winners of its awards programmes to nominate a colleague who brings out the best in them.

www.nature.com/articles/d41...

03.03.2026 05:47 πŸ‘ 76 πŸ” 20 πŸ’¬ 2 πŸ“Œ 1

That looks amazing! I'm away this week, missed it.

02.03.2026 09:56 πŸ‘ 1 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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Long-term waning of vaccine-induced immunity to measles in England: a mathematical modelling study Measles case dynamics in England are consistent with scenarios assuming the waning of vaccine-induced immunity. Since measles is highly infectious, slow waning leads to a heightened burden in outbreak...

There's epi/modelling work, eg this one looking at England. Overall, waning happens, however, it's very slow compared to many other viral vaccines. It's not impossible to get infected if you were vaccinated and on a population level adds up, individual risk low.

www.thelancet.com/journals/lan...

01.03.2026 11:48 πŸ‘ 3 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

The updated International Committee of Medical Journal Editors (ICMJE) recommendations suggest what journals can do to ensure appropriate use of AI, but real compliance starts in the institutions where researchers learn their habits. buff.ly/DVxxIJZ

27.02.2026 08:02 πŸ‘ 0 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0

Anyway, thanks for the paper. Very interesting!

25.02.2026 12:08 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Less screening leads to longer TATs. Also not sure whether one can directly compare initial desk decision with peer review decisions. For selective journals can former can be done quite reliably. Second is not only about accept/reject, more so about improving article.

25.02.2026 12:08 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

I'm obviously biased
, but as an editor at a selective journal, I'm not sure whether tighter screening and desk rejections really turns authors off submitting. If they have a high-quality paper, they want it published with other high-quality peer papers. What turns them off is very long TATs.

25.02.2026 12:08 πŸ‘ 1 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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Nature News Intern, Springer Nature Opening Doors Programme Nature News Intern, Springer Nature Opening Doors Programme London, UK - Hybrid Working Model Application deadline: 9th March 2026 Are you looking for an internship that provides hands-on experience i...

➑️ It's on! Paid internship for aspiring science journalists at Nature's London office. Up to three days a week working from home. All the details are here: springernature.wd3.myworkdayjobs.com/en-US/Spring...

24.02.2026 14:56 πŸ‘ 6 πŸ” 9 πŸ’¬ 0 πŸ“Œ 0

Also, I wouldn't rate longer reports and longer replies as a positive outcome...

24.02.2026 13:30 πŸ‘ 1 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

Loved this week's episode; never a good sign if your surgeon says yikes... Also wondering whether John Tothill was in one of our malaria challenge papers.

24.02.2026 10:41 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Reading peer review reports: Reviewer 2 saying I LOVE THIS, BRAVO in all caps. My heart ❀️😊πŸ₯²

23.02.2026 10:50 πŸ‘ 5 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

What annoys me is if protocols are heavily redacted because of commercial or competition concerns. Ok, don't want to publish everything in appendix but at least need transparency for editorial assessment and peer review.

Rant over πŸ˜‰

22.02.2026 13:17 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

For clinical trials, we check protocols before publication. Can be complex though, eg if there's protocol changes, trials are registered in more than one registry, or protocols are not in English (we ask for translation or editorial colleague who knows language check, love diverse Lancet team).

22.02.2026 13:17 πŸ‘ 1 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

Exactly. Issued when there are concerns warranting further investigation (usually by institution). What happens afterwards depends on findings. Correction, retraction, no action. For last, I would like to see note to say investigated and resolved. Doesn't always happen.

22.02.2026 13:17 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

Exactly. That and how much strain regular stuff such as commuting or being 'on' in an office for a traditional workday can put on disabled people. It's a shame that much of the progress in flexible working is being rolled back.

22.02.2026 12:51 πŸ‘ 3 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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A potential late sequelae of measles after normal recovery.
Occurs in ~ 2/10,000. Fatal.
www.nejm.org/doi/full/10.... @nejm.org today

21.02.2026 14:48 πŸ‘ 193 πŸ” 77 πŸ’¬ 6 πŸ“Œ 4
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New Documents Reveal a Controversial Vaccine Study's Unusual Path to CDC Approval A new investigation has found irregularities in the ethics review of a grant to study effects of a birth dose of hepatitis B vaccine in Guinea-Bissau.

πŸ§ͺ #ResearchEthics

Appalling Guinea Bissau #hepB #vaccine trial
β€žan international ethics fiasco[…]

β€žβ€¦CDC appointees allied with Kennedy circumvented critical scientific and ethical safeguardsβ€¦β€ž

Kudos to investigative journalist @katherineeban.bsky.social

www.rollingstone.com/politics/pol...

21.02.2026 05:25 πŸ‘ 25 πŸ” 15 πŸ’¬ 1 πŸ“Œ 0
Panel A shows the cumulative incidence of regimen failure (the primary outcome), which was defined as the earliest occurrence of either virologic failure or permanent discontinuation of the trial treatment. Also shown is the cumulative incidence of virologic failure, treatment-related failure (defined as the earliest occurrence of virologic failure or premature treatment discontinuation due to treatment-related adverse events), and permanent discontinuation (key secondary outcomes). Panel B shows the times to regimen failure and virologic failure in step 2. The week 48 visit was performed within a prespecified window (>42 to 50 weeks after randomization). CI denotes confidence interval.

Panel A shows the cumulative incidence of regimen failure (the primary outcome), which was defined as the earliest occurrence of either virologic failure or permanent discontinuation of the trial treatment. Also shown is the cumulative incidence of virologic failure, treatment-related failure (defined as the earliest occurrence of virologic failure or premature treatment discontinuation due to treatment-related adverse events), and permanent discontinuation (key secondary outcomes). Panel B shows the times to regimen failure and virologic failure in step 2. The week 48 visit was performed within a prespecified window (>42 to 50 weeks after randomization). CI denotes confidence interval.

Cabotegravir plus Rilpivirine for Persons with HIV and Adherence Challenges

Aadia Rana & co for the ACTG A5359 LATITUDE Trial Team

Monthly cabotegravir–rilpivirine were superior to standard ART in reducing failure among PWH who had adherence challenges

www.nejm.org/doi/full/10.... #IDSky #HIVSky

19.02.2026 13:33 πŸ‘ 10 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0

Zing, virus taxonomy wars continue. Language stickler in me welcomes the zeal for order and correctness. Although, if one were very strict that acknowledgement heading should maybe be renamed as conflicts of interest...

20.02.2026 10:33 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
Fluffy tabby cat sitting on a bed, head half turned backwards towards camera, looking accusingly

Fluffy tabby cat sitting on a bed, head half turned backwards towards camera, looking accusingly

Side eye from a resentful cat. Tonight's atrocities will not be forgiven. Humans left to go to a sea shanty concert each assuming the other one had already fed the cat. Barely escaped starvation.

19.02.2026 21:28 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Everyone can easily find our email, there really is no priority access. If you do decide to send a presub, then at least please include an abstract, full paper if you already have it.

19.02.2026 21:22 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Mucosal vaccination in mice provides protection from diverse respiratory threats Traditional vaccines target specific pathogens, limiting their scope against diverse respiratory threats. We describe an intranasal liposomal formulation combining toll-like receptor (TLR) 4 and 7/8 l...

Not disparaging original paper, very interesting basic science

19.02.2026 21:15 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0