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Anna-Leigh Brown

@annaleighbrown

Computational RNA biologist. Just trynna figure stuff out.

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08.12.2023
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Latest posts by Anna-Leigh Brown @annaleighbrown

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And finally, we offer a Shiny app where you can explore all our data and results!
anna-leigh-brown.shinyapps.io/Cryptic-Cree...

24.11.2025 11:28 ๐Ÿ‘ 0 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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How do disease types affect cryptic splicing?

24.11.2025 11:28 ๐Ÿ‘ 0 ๐Ÿ” 0 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0
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Which cryptic events are specific to TDP-43 proteinopathies?

24.11.2025 11:28 ๐Ÿ‘ 0 ๐Ÿ” 0 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0
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Which cryptic splicing events make it to the cytoplasm?

24.11.2025 11:28 ๐Ÿ‘ 1 ๐Ÿ” 0 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0
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Cryptic splicing is an important part of TDP-43 proteinopathies, but many questions remain. For example...
Which cryptic splicing events show up first when TDP-43 starts to malfunction?

24.11.2025 11:28 ๐Ÿ‘ 0 ๐Ÿ” 0 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0
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Sensitivity to TDP-43 loss and degradation resistance determine cryptic exon biomarker potential Cryptic splicing caused by TDP-43 proteinopathy is a hallmark of the neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). However, which cryptic splicing e...

Man do I miss the good ole days when I could tweet a new paper without thinking about the existential dread of feeding the algorithms.
Anyway - on the off chance this still works in the way I remember,
We've got a new preprint!
www.biorxiv.org/content/10.1...

24.11.2025 11:28 ๐Ÿ‘ 3 ๐Ÿ” 1 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 1

You under estimate my ability to procrastinate with the BioRxiv preprint bot

08.12.2023 15:24 ๐Ÿ‘ 0 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

I feel a bit ambivalent about more social media. Elon Musk had helped me quit my last social media addiction when he ransacked Twitter, but I did miss getting paper updates randomly...

08.12.2023 11:50 ๐Ÿ‘ 5 ๐Ÿ” 0 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0