New paper out: HIF-1ฮฑ+ CD4+ T cells coordinate a tissue-resident immune cell network in the lung
www.sciencedirect.com/science/arti...
06.03.2026 22:42
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New paper out: HIF-1ฮฑ+ CD4+ T cells coordinate a tissue-resident immune cell network in the lung
www.sciencedirect.com/science/arti...
๐จ ๐๐ ๐ฆ๐๐๐ญ๐ฌ ๐๐ ๐๐ซ๐ฎ๐ ๐๐ข๐ฌ๐๐จ๐ฏ๐๐ซ๐ฒ!
Imaging ๐ถ. ๐๐๐ข๐ก๐๐๐๐๐ข๐ (a model for ๐. ๐ก๐ข๐๐๐๐๐ข๐๐๐ ๐๐ ) + deep learning reveals known, unseen, and novel antibiotic modes of action from images alone, a leap for TB drug discovery.
โ๏ธ @awehenkel.bsky.social & coll.
๐ shorturl.at/9QPDy
#Tuberculosis #MicroSky
Our new paper is out in @lsajournal.org
We explored how glycolysis inhibition in tuberculosis-infected macrophages can reduce HIV-1 spread.
๐ Read it here: doi.org/10.26508/lsa...
Huge thanks to @Zoi Vahlas, @lucianabalboa.bsky.social, @oneyrolles.bsky.social & @chrisverollet.bsky.social
Thank you @embojournal.org! ๐
The editorial process was genuinely exceptional: thoughtful, collaborative, and constructive. If only all journals had editors who truly act as editors!
How can bacterial pathogens weather metal ion stress during infection?
@pierredupuy.bsky.social, @oneyrolles.bsky.social et al implicate โeffluxosomesโ, membrane clusters of metal-binding chaperones & exporters coordinating M. tuberculosis resistance to toxic metals
link.springer.com/article/10.1...
#ResultatScientifique๐| La bactรฉrie responsable de la tuberculose est capable d'รฉvacuer les mรฉtaux toxiques pour rรฉsister au systรจme immunitaire
โ๏ธ @oneyrolles.bsky.social
๐ค @ipbstoulouse.bsky.social
๐ buff.ly/4R5iaMB
โถ๏ธ
๐ @pierredupuy.bsky.social and colleagues!
@genotoul.bsky.social @agencerecherche.bsky.social @anrs-mie.bsky.social ...
And... @yoannrombouts.bsky.social, inventor of the word "effluxosome"! ๐
Beyond the science, I want to highlight the peer review at @embojournal.orgโtruly constructive, collaborative, and scientific dialogue that strengthened the work at every step.
Conceptually, this work:
๐ฌ Introduces effluxosomes as a new paradigm for bacterial membrane organization
๐งช Shows how pathogens coordinate multi-metal resistance
๐ Opens potential avenues for new antimicrobials against tuberculosis.
PacL1 acts as a multi-substrate metallochaperone, and the effluxosomes connect to a broad interaction networkโthese are not isolated modules but part of a coordinated stress adaptation program.
...
Using single-particle tracking and single-molecule super-resolution microscopy, we show these effluxosomes are highly dynamic, stabilizing metal-export pumps and coordinating resistance to zinc, cadmium & copper.
...
The bacterium assembles dynamic membrane platforms organized by PacL proteins, clustering P-type ATPase pumps into functional complexes we call โeffluxosomes.โ
...
๐ ๐๐ฑ๐๐ข๐ญ๐๐ ๐ญ๐จ ๐ฌ๐ก๐๐ซ๐ ๐จ๐ฎ๐ซ ๐ง๐๐ฐ ๐ฉ๐ฎ๐๐ฅ๐ข๐๐๐ญ๐ข๐จ๐ง ๐ข๐ง ๐๐ก๐ ๐๐๐๐ ๐๐จ๐ฎ๐ซ๐ง๐๐ฅ!
After 8 months of revision, our work is now online: shorturl.at/WHmFq
We uncover a previously unrecognized way that ๐๐ฆ๐๐๐๐๐๐ก๐๐๐๐ข๐ ๐ก๐ข๐๐๐๐๐ข๐๐๐ ๐๐ survives toxic metal stress during infection.
...
So inspiring to see the next generation of researchers in action. Their science gets clearer and more impactful every year.
Watching Max Caouaille and Aizat Abdul at #TBVAC was genuinely moving. Great science, great storytelling, huge passion.
The future of research is in very good hands. ๐
The Barber lab is looking to hire post-docs to work on #tuberculosis #immunology using murine and NHP models. BSL3 experience not required. Check out our lab in the NIH intramural program in Bethesda MD!
A great meeting ahead for host and pathogen aficionados! Keynote speakers: Florence Niedergang (Cochin) and Raphael Valdivia (Duke)- plenty of opportunities for early career researchers to present their work and a very collegial and supportive network. Belfast here we go! Please repost.
#Immunosky #Glycobiology #Infection #Monocyte
These findings open new avenues for targeting monocyte mobilization in inflammatory diseases, infections, and autoimmune disorders like lupus.
๐ Huge thanks to the team, and our collaborators! Supported by @agencerecherche.bsky.social, @frm-officiel.bsky.social, and Bettencourt Schueller Foundation.
...
๐น NCAM1 is the main polysialic acid carrier in inflammatory monocytes, and its loss phenocopies ST8SIA4 deficiency.
๐น Polysialylation regulates CCR2 surface distribution, cytoskeleton, and chemokine binding, revealing a new mechanism controlling immune cell trafficking.
Key findings include:
๐น Human ๐๐8๐๐ผ๐ด4 variants are associated with lower monocyte and lymphocyte counts and higher SLE risk.
๐น ST8SIA4 deficiency causes monocytopenia in mice by impairing CCR2-dependent monocyte exit from bone marrow.
...
Inflammatory monocytes are critical for fighting infections (like tuberculosis) and regulating inflammation. We found that the enzyme ST8SIA4, through polysialylation, controls their egress from the bone marrow via the CCR2 receptor, both at steady state and during ๐. ๐ก๐ข๐๐๐๐๐ข๐๐๐ ๐๐ infection.
๐ฅณ ๐๐ฑ๐๐ข๐ญ๐๐ ๐ญ๐จ ๐ฌ๐ก๐๐ซ๐ ๐จ๐ฎ๐ซ ๐ฅ๐๐ญ๐๐ฌ๐ญ ๐ฐ๐จ๐ซ๐ค ๐ฌ๐ก๐จ๐ฐ๐ข๐ง๐ ๐ก๐จ๐ฐ ๐ฉ๐จ๐ฅ๐ฒ๐ฌ๐ข๐๐ฅ๐ฒ๐ฅ๐๐ญ๐ข๐จ๐ง, ๐ ๐ซ๐๐ซ๐ ๐ฉ๐ซ๐จ๐ญ๐๐ข๐ง ๐ฆ๐จ๐๐ข๐๐ข๐๐๐ญ๐ข๐จ๐ง, ๐ซ๐๐ ๐ฎ๐ฅ๐๐ญ๐๐ฌ ๐ข๐ง๐๐ฅ๐๐ฆ๐ฆ๐๐ญ๐จ๐ซ๐ฒ ๐ฆ๐จ๐ง๐จ๐๐ฒ๐ญ๐ ๐ฆ๐จ๐๐ข๐ฅ๐ข๐ณ๐๐ญ๐ข๐จ๐ง ๐๐ซ๐จ๐ฆ ๐ญ๐ก๐ ๐๐จ๐ง๐ ๐ฆ๐๐ซ๐ซ๐จ๐ฐ.
โ๏ธ Aurรฉlien Boyancรฉ, Nelly Gilles, @yoannrombouts.bsky.social & coll. @ipbstoulouse.bsky.social
๐ shorturl.at/IDwza
๐ A short thread...
Nothing like a good meal with an even better team.
Hereโs to a bright, productive 2026! ๐คฉ
@mcaouaille.bsky.social @saurabhchugh09.bsky.social @vogeleerp.bsky.social @yoannrombouts.bsky.social & more!
Two pieces of fun news:
1. We've launched a new website for our lab: www.brysonlab.org
2. With some new funding, we are recruiting for new postdocs and graduate students. The projects build upon our previous studies of antigen presentation and phagosome biology and go into new exciting dimensions!
๐จ We are excited to announce that @virginiestevenin.bsky.social has been awarded a starting grant from the @frm-officiel.bsky.social to establish her research team at IPBS and study the nutrition of pathogenic bacteria inside human host cells.
More info: shorturl.at/U6zSa
#MicroSky #Salmonella
A big thank-you to @sheetalgandotra.bsky.social & @vivekrao.bsky.social and everyone at CSIR-IGIB for their warm welcome! ๐
What a wonderful day with incredibly friendly hosts and such brilliant, motivated students!
๐ซ๐ท๐ฎ๐ณ Long live Franco-Indian cooperation!
Huge congratulations to the entire team and to @mcaouaille.bsky.social for this outstanding PhD thesis work; an ambitious, beautifully executed study that pushes both TB immunology and intravital imaging into entirely new territory.
#Tuberculosis #ImmunoSky #MicroSky #Microscopy
Combined with spectral cytometry and single-cell RNA-seq, these findings reveal how IFN-Iโdriven pathology creates physical and molecular barriers that undermine adaptive immunity, and how targeting this axis may reopen the path for effective T cellโmediated control of TB.
๐จ๐๐ถ๐ป๐ด ๐๐ต๐ถ๐ ๐ฎ๐ฝ๐ฝ๐ฟ๐ผ๐ฎ๐ฐ๐ต, ๐๐ฒ ๐ณ๐ผ๐๐ป๐ฑ ๐๐ต๐ฎ๐:
โข Without SP140, excess IFN-I traps CD8โบ and CD4โบ T cells and prevents their movement in lesions.
โข The few T cells that enter become almost immobile.
โข Blocking IFNAR fully restores T cell motility and surveillance.
๐ฌ ๐๐ถ๐ฟ๐๐-๐ฒ๐๐ฒ๐ฟ ๐ถ๐ป๐๐ฟ๐ฎ๐๐ถ๐๐ฎ๐น ๐น๐๐ป๐ด ๐บ๐ถ๐ฐ๐ฟ๐ผ๐๐ฐ๐ผ๐ฝ๐ ๐ถ๐ป ๐ง๐ allowed us to watch T cells in real time inside infected lesions, an unprecedented view made possible by the work of Emma Lefranรงais, Lรฉa Fromont & colleagues. Preprint here: shorturl.at/gm20H