Naveen Jain

Thanks Ian! Now I low-key want to check vitamin C on every single one of my patients with anemia 😆

3/ This was my first stab at clinical writing, and I enjoyed pushing myself to work through all of the logic behind our clinical decision-making. Most importantly, identifying and treating this patient's underlying disease process very quickly and effectively cured her symptoms!

2/ Thank you to Dr. Ron Berna and Dr. Emily Hejazi (Derm), Dr. Steven Pugliese (PCC), and my mentor Dr. Mia Djulbegovic (H/O) for your collaboration in managing and writing-up this complicated case. Thank you also to Dr. Aileen Ren and Dr. Adam Cuker for your perspective and support!

1/ Really neat case I helped with on my inpatient hematology rotation at @pennmedicine.bsky.social. Won't say too much to avoid spoilers, but definitely a head scratcher. Thank you to everybody who helped care for her and also Dr. Caren Solomon and @nejm.org for a constructive revision process!

Excited and grateful that our initial report on temperature-sensitive protein switches is now published
@naturemethods.bsky.social Co-led by PhD students Will Benman and @dennishuang.bsky.social

www.nature.com/articles/s41...

Brief thread:

Multiscale footprints reveal the organization of cis-regulatory elements - Nature We developed PRINT, a computational method that identifies footprints of DNA–protein interactions from bulk and single-cell chromatin accessibility data across multiple scales of protein size.

Super excited to share our new study from the @jbuenrostro.bsky.social Lab in @nature.com! We developed a computational method for tracking transcription factor and nucleosome binding using single-cell ATAC-seq and deep learning.
Paper: www.nature.com/articles/s41...

Immune evasion through mitochondrial transfer in the tumour microenvironment - Nature Mitochondria with mutations in their DNA from cancer cells can be transferred to T cells in the tumour microenvironment, which leads to T cell dysfunction and impaired antitumour immunity.

Apparently cancer cells can pass defective mitochondria, effectively a metabolic poison, onto T cells as a mechanism of immune evasion. Who knew! Importantly, specific mtDNA mutations also predict poor clinical response to immune checkpoint inhibitors. www.nature.com/articles/s41...

Emx2 underlies the development and evolution of marsupial gliding membranes - Nature Patagia—the mammalian gliding membrane—repeatedly originated through a process of convergent genomic evolution, whereby the regulation of Emx2 was altered by distinct cis-regulatory elements in indepe...

Just saw Ricardo Mallarino present his lab's innovative work on uncovering the molecular mechanisms of developmental programs driving biological diversity in a number of nonconventional model organisms. This study in particular in sugar gliders blew my mind!
www.nature.com/articles/s41...

Enhancer scrambling strategy

We are happy to share our enhancer scramble story, a strategy to create hundreds of stochastic deletions, inversions, and duplications within mammalian gene regulatory regions and associate these new architectures with gene expression levels 🧵
www.biorxiv.org/content/10.1...

Excited to share James Jusuf's preprint:

By integrating Micro-C with SuperRes Live-Imaging we can calibrate genomics&imaging to perform absolute quantification of looping (e.g. this loop is present 3%)

We quantify mESC 36k loops: <loops> are generally rare (2.3%)

www.biorxiv.org/content/10.1...