Some MDVs contribute to the de novo peroxisome #biogenesis through interactions between mitochondria and the ER, a process dependent on DRP1 and peroxisomal proteins. These vesicles enable vesicle-mediated transport and inter-organelle communication essential for maintaining neuronal homeostasis.

vesicles involved in the removal of damaged mitochondrial components, small functional #
mitochondria that support cellular energy processes, and vesicles that transport newly synthesized proteins for local organelle formation.

With multicolor #STED nanoscopy, we identified 3 structurally and functionally distinct types of #MDVs in primary neurons:

Quantitative optical nanoscopy of mitochondrial-derived vesicles in neurons classifies pre-peroxisomal and clearing organelles - Nature Communications STED nanoscopy reveals structural and functional diversity in Neuronal MDVs including degradation and protein transport for organelle biogenesis.

I am very happy to share the last work of the TestaLab! A long and fruitful collaborative journey! I would like to thank all the co-authors, starting form @IlariaTesta, @JonatanAlvelid @martinaDamenti @GabriellaFerretti @JohannesMueller @JoannaRorbach
www.nature.com/articles/s41...