@auclairlab
We explore many fields of chemistry and biology (many of them concerning enzymes). Located at McGill University, Montreal. Student-ran account: posts not by Dr. Auclair unless indicated. RP/follow ≠ endorsement. https://www.auclair-group.mcgill.ca
Some updates:
The Auclair lab congratulates Aracelli Chang on a successful Master's thesis submission!
And we're happy to officially welcome Dr. Jacob Pierscianowski back as a post-doc! Dr. Jake defended his thesis with us last year.
One decade ago: the Auclair lab first examined small molecules to resensitize bacteria to macrophages. #chemsky #biosky
doi.org/10.1002/cbic...
It's a full queue kind of day #chemsky
Congratulations to Natalia for receiving a PROTEO graduate scholarship! proteo.ca/en/news-and-...
Freezer defrosting day means freezer sorting day #chemsky
First thiol smell of the new year. And it's not even a particularly noxious one! #chemsky
We're officially back for the new year. The built-up freezer ice looks so neat it's almost a shame to de-ice it all.
This is our freezer for the next few hours #chemsky
Check out some of the great work being done by our collaborators in the Schmeing lab in Biochemistry!
In partnership with the Canadian Light Source's beamline, they're examining the structure and workings of itaconate-degrading enzymes.
#chemsky #biochemsky
www.linkedin.com/posts/canlig...
Prof. Auclair presented at the McGill Interdisciplinary Initiative in Infection and Immunity (MI4) annual symposium last week!
Come find us at @concordia.ca Loyola campus for CBGRC this Friday!
NEW PREPRINT:
An extensive structure-activity relationship investigation of pantetheinamides and their ability to inhibit Salmonella typhimurium.
We investigate the mechanisms of action of these compounds and their use with in vivo mouse models.
doi.org/10.1101/2025...
From the Auclair lab: Dr. Jacob Pierscianowski, Dr. Dustin Duncan, Dr. Blue Lan, Dr. Rohit Kholiya, Suzana Diaconescu-Grabari, Ahmed B. Abdelaal, Aracelli Chang, Shay Heans, Dr. Sanjay Campbell, Dr. Alexandre Pierret.
With collaboration from the groups of Profs. Schmeing, Findlay, and Lupien.
NEW PREPRINT:
An extensive structure-activity relationship investigation of pantetheinamides and their ability to inhibit Salmonella typhimurium.
We investigate the mechanisms of action of these compounds and their use with in vivo mouse models.
doi.org/10.1101/2025...
Here's some more balanced centrifuge arrangements #chemsky
We're incredibly proud to announce Dr. Jacob Pierscianowski has officially defended his PhD thesis!
Congratulations to Dr. Jake on the amazing work.
Good Wordle yesterday.
Update: purified it anyways. Fraction looks reasonably pure. Now let's see the activity tests. #chemsky
The Auclair Lab welcomes two new members!
Maya Gaylor, co-supervised by Prof. Lupien in Microbiology and Immunology, will be working on our antimicrobial projects.
Dr. Alana Rangaswamy is a recent graduate from the Keillor lab @uottawa.ca and will focus on enzyme and depolymerization efforts.
Admin got up yesterday at 7 in the morning to perform a transformation that probably didn't work. One (1) colony on the plates. This is the #chembiosky life.
Fun fact: we scheduled our lab cleanup day a few weeks ago, and the second we finished up, we got a notification that we were having a safety inspection the very next Monday.
Talk about good timing #chemsky
Many members of the Auclair lab hosted and attended the student-led Careers After Chemistry conference! #CAC2025 #chemsky
Literal green chemistry #chemsky
Doing a little setup for our new baby 👀
New instrument 🔜🔜🔜
Sign up for McGill Chemistry's Careers After Chemistry 2025 conference! Registration ends September 5.
cacmcgill.wixsite.com/cac2025/regi...
The Auclair lab went tree trekking recently! Super fun teambuilding exercise.
Very happy to meet 2020 Nobel Prize laureate @e-charpentier.bsky.social at @ircm.bsky.social!
‼️NEW PAPER ALERT
In Antimicrobial Agents and Chemotherapy, we replace an enzyme-vulnerable amide bond with a thiazole to produce potent antiplasmodial and antimalarial pantothenamide mimics. A collaboration between the Auclair lab @mcgill.ca and the Saliba lab at ANU.
doi.org/10.1128/aac....
🧵
Another day, another paper 😌
