Cornell Center for Enervating Neuroimmune Disease

Multiple Abnormal Responses to Exertion Seen in ME/CFS Findings underscore the risk for graded exercise in people with post-exertional malaise and point to careful activity pacing as a safer approach.

This work by Germain et al. has also been featured on Medscape.
www.medscape.com/viewarticle/...

Center researchers performed longitudinal plasma proteomics (SomaScan7K ) in 79 #MECFS vs 53 controls around two maximal CPETs. Findings: Persistent immune & metabolic dysregulation in recovery, linked to PEM. Learn more on our website.

neuroimmune.cornell.edu/news/uncover...

#PEM #Research

Invisible Illness Report 2025 via Not Just Fatigue

Please also watch this great video with Prof. Maureen Hanson* on the state of #ME/CFS research and the need for major funding to better understand its pathophysiology and find treatments
* @cornellmecfs.bsky.social

x.com/njfatigue/st...

Abstract illustration of cell-free RNA (cfRNA) and other cellular components dissolving into compartments within and into a fluid solution, evoking blood plasma and circulating biomarkers in ME/CFS research; red, blue, and tan background with blue, tan, red, and orange vesicles and molecules. Image made using Adobe Firefly.

New work from our Center team 🤝: blood cell-free RNA 🧬 may help us understand—and one day diagnose—MECFS. Analysis reveals immune dysfunctions as seen in other studies. Great cross-lab collaboration between our De Vlaminck, Grimson, and Hanson Labs. More info: neuroimmune.cornell.edu/news/cell-fr...

Analysis shows impaired energy metabolism, upregulated complement system, and dysregulated protein folding. Proteomic changes were associated with ME/CFS patients’ post-exertional malaise, unrefreshing sleep, and functional capacity.

🔬 NEW from @cornellmecfs.bsky.social : Study reveals protein changes in #MECFS using blood-derived extracellular vesicles. First analysis in male patients shows altered EV cargo dynamics post-exercise.

🔓 Read: doi.org/10.1002/ctm2...
📊 Data: mapMECFS.org

🔍 New study from Center examines role of autoantibodies in #MECFS. 🧪 Using advanced screening of 7,500+ antibody-antigen interactions in 172 participants, researchers found no significant differences between patients & controls. 📄 Read more: doi.org/10.3390/ijms...

Immune T cells become exhausted in chronic fatigue syndrome patients | Cornell Chronicle The study found that key CD8+ T cells showed signs of constant stimulation that lead to an exhausted state, a condition that is well-studied in cancer.

📢 New insights into #MECFS: Research from our Center reveals how T cells become exhausted in ME/CFS patients. 🧬 Learn more about the study and its implications in the Cornell Chronicle article: news.cornell.edu/stories/2024... #TCells #Immunology