Bone marrow-derived inflammatory signals may shape glomerular disease in ways that we are only beginning to understand. Read this article in #ASNKidneyNews following one of the most prominent and debated candidates, suPAR: kidney.pub/KN1802-15
π₯Proud to share our latest #PKD prognostic model from CRISP IV
In ADPKD pts with normal eGFR we can predict probability of kidney failure 15 years later with C-index >0.8
Uses only TKV + data obtained in usual clinical care
Autosomal dominant polycystic kidney disease (ADPKD) is linked to mutations in PKD1 and PKD2 genes, affecting cation channel complexes in kidney cell cilia. This #ASNJASN study explored ways to increase these complexes in cilia to prevent kidney cyst formation: kidney.pub/JASN0942
Cystogenesis and interstitial fibrosis are contributing factors to kidney failure in individuals with ADPKD. This #ASNJASN research examines the role of Integrin Alpha1 Beta1 in a mouse model: kidney.pub/JASN0941 #BasicResearch
@rachellennon.bsky.social
Honored to have @juancarlosqvelez.bsky.social visiting KU Nephrology and the Jared Grantham Kidney Institute.
Fantastic lecture on #hepatorenal syndrome (of course)π
Lots of practical recommendations backed up by research conducted by Dr. Velez at @ochsnerhealth.bsky.social
Delighted to have you visit and thank you for a fabulous talk!π
Nice editorial by bsky.app/profile/hump...
highlighting our new @jci.org paper π
jci.org/articles/vie...
~15 years ago, Dr. Fred Coe put forward the βvas washdownβ model for explaining kidney stone formation
@alanyuneph.bsky.social & team now report on a new mouse model, showing kidney-specific Cldn-2 KO leads to medullary nephrocalcinosisβsupporting the vas washdown model: doi.org/10.1172/JCI1...
Now out @jclinicalinvest led by Christine_Behm with fantastic team of collaboratorsπ
We discover a corticomedullary gradient for Ca in kidney and show a critical role for claudin-2, with implications for kidney stone disease.
@kumedcenter.bsky.social
www.jci.org/articles/vie...
Join us in congratulating this winner of the Distinguished Leader Award, an ASN Midcareer Award: Reem A. Mustafa, MD PhD MPH FASN. Read more about her work in #ASNKidneyNews: kidney.pub/KN1710-41
New podcast alert! Dr. Priya Vart discusses the results of his study, βEffects of Dapagliflozin on Health-Related Quality of Life in Patients with CKD,β with #ASNJASN Deputy Editor Manjula Kurella Tamura: kidney.pub/JPOD0776
LBRO
And in the evening
- a CAR T in refractory SLE
- a PKD trial
- increasing PD in Vets
- Povetacicept in IgA
- TESTING Longterm term data
- what do the AHA/ACC BP guidelines mean?
#KidneyWk
Starting Soon! Join us for the 2025 Best of ASN Journals session at #KidneyWk. Join us Tomorrow, Thursday, November 6 at 2:00 PM in Grand Ballroom A of the George R. Brown Convention Center for a lively discussion and check out the article collection below.
kidney.pub/BestOf2025
The 2025 #ASNJASN #ASNCJASN and #ASNKidney360 Trainees of the Year are Benoit βBrilland, Thomas Bais, and Yuhei Noda! This prize celebrates the best article submitted to each journal by a trainee as the first author.
See more about the contest and this year's winners: kidney.pub/TraineeOf...
Congratulations π
New in #ASNJASN: an epigenetic CRISPR Screen was used for the first time to identify critical genes and pathways involved in vascular calcification. kidney.pub/JASN0793
Serum creatinine trajectory showing rapid rise to peak and prompt recovery over 3 days
Who says there are no good treatments for AKI?
πClassic HRS-AKI with dramatic reversal by terlipressin
#medsky #nephsky
NEW on the #AJKDBlog:
@maximalchange.bsky.social interviews the authors of a recent review of ADPKD, Sara S. Jdiaa and Reem A. Mustafa, and discusses prognosis, goals, and monitoring.
bit.ly/Jdiaa25 (FREE)
In a recent #ASNJASN article, authors report that ephrin-B1 at slit diaphragm suppresses cdc42 activity by preventing the interaction of Par6 with cdc42 and functions to keep the specialized phenotype of podocytes. Read more: kidney.pub/JASN0728 #BasicResearch
Genetically modified gut bacteria show promise of combating kidney stones in clinical trial medicalxpress.com/news/2025-07...
NEW on the #AJKDBlog:
@maximalchange.bsky.social interviews the authors of a recent review of ADPKD, Sara S. Jdiaa and Reem A. Mustafa, and discusses prognosis, goals, and monitoring.
bit.ly/Jdiaa25 (FREE)
β³ One week left to apply. The Fellowsβ Travel Support Scholarship gives nephrology fellows $1,000 to attend the UAB CRRT Academy. Train in person, build practical CRRT skills, and learn through simulation and expert-led sessions. Apply by Monday, July 21 π bit.ly/3FGntEx
Congratulations π
Guidelines no longer recommend holding typical first-line antihypertensive meds since renin will most often still be suppressed despite being on them in true PA. Growing evidence supports proceeding with screening
Hot off the press from the Endo Society: www.endocrine.org/clinical-pra...
Congratulations!π
Could gene-targeted therapy be coming for autosomal dominant polycystic kidney disease? Farabursen, a new medication acquired by Novartis offers to potentially impact cyst formation and even regression. kidney.pub/KN1707-07 #ASNKidneyNews
@nephrosparks.bsky.social
π‘ππͺ π₯ππ¦π’π¨π₯ππ ππππ₯π§: Download our #ADPKD infographic for a quick overview of diagnosis, delaying progression, complications & more. A handy resource for clinicians and patients alike!
β¬οΈhttps://www.theisn.org/wp-content/uploads/2025/07/ADPKD-Infographic.pdf
π₯Submit a Late-Breaking Clinical Trial and have your study considered for contemporaneous publication in JASN, NEJM @nejm.org or Lancet @thelancet.com
Understanding the role of alternative splicing in podocyte biology may lead to theraputic options for patients with glomerular hypertension. Read more in a #BasicResearch article: kidney.pub/JASN0706 #ASNJASN
The 2026 RFAs for grant and fellowship awards from @pkdfoundation.bsky.social are out!
Grant: pkdcure.org/research/gra...
Fellowship: pkdcure.org/research/fel...
LOIs are due August 11. Send us your best ideas!!
