Armelle

A summary table on published observational studies on treatment duration of bloodstream infections in hematology patients with high-risk neutropenia. References: doi: 10.1007/s10096-024-04885-w doi: 10.1111/tid.14085 doi: 10.1016/j.jinf.2021.10.017 doi: 10.1093/cid/ciad605 doi: 10.1093/ofid/ofaa246

A summary table on published observational studies on treatment duration of graft infections on solid-organ transplant recipients. References: doi: 10.1111/tid.13896 doi: 10.1111/tri.14144 doi: 10.1111/tid.13868 doi: 10.1111/tid.13518

#ShorterIsBetter in immunocompromised hosts?
Short treatments are feasible in early responders without source control issues.

A significant number of observational studies serve as proof-of-concept on the feasibility of short courses in selected patients (see ⚠️)

#AMSsky #IDOnc #TxID #IDsky

Levofloxacin prophylaxis in pediatric and young adult allogeneic hematopoietic stem cell transplantation recipients does not prevent infective complications and infections-related deaths AbstractBackground. The prophylactic use of quinolones in the setting of allogeneic hematopoietic stem cell transplantation (allo-HCT) is controversial and

🆕✨Single-center retrospective
Levofloxacin prophylaxis in pediatric & young adult allogeneic hematopoietic stem cell transplantation recipients does not prevent infective complications & infections-related deaths & 🔼prevalence of Abx resistant strains #idsky #medsky
academic.oup.com/ofid/advance...

Coccidioidomycosis Transmission Through Solid Organ Transplantation (2013–2022): A Report of the Organ Procurement and Transplantation Network ad hoc Disease Transmission Advisory Committee Coccidioides infection is a rare but serious fungal disease. From 2013 to 2022, most donors with risk factors lacked serologic testing before procurement, and recipients often missed necessary prophy...

Report from the OPTN ad hoc Disease Transmission Advisory Committee - Coccidiomycosis from Organ transplant Donors?

"All 7 deceased donors had prior infection or exposure...8/20 recipients developed Cocci, resulting in a 40% transmission rate." #IDsky #TxID

onlinelibrary.wiley.com/doi/10.1111/...

If they suspect Aspergillosis why use posa and not voriconazole?

Renal transplantation using kidneys from a donor with high grade cytomegalovirus viraemia: case report and literature review Transplanting organs from cytomegalovirus-seropositive donors into cytomegalovirus-seronegative recipients is an accepted practice. However, outcomes following transplantation of organs from donors wi...

www.thelancet.com/journals/lan...

Lessons from practice for immunocompromised hosts by Dr Ai Li Yeo and A/Prof Claire Dendle
#ForbesWeek #IDSky
1. There can be more than two pathologies in immunocompromised patients

Drug–Drug Interaction Management with the Novel Anti-Cytomegalovirus Agents Letermovir and Maribavir: Guidance for Clinicians - Clinical Pharmacokinetics Letermovir and maribavir have demonstrated efficacy in the prevention and treatment, respectively, of immunosuppressed patients with cytomegalovirus (CMV) infection and disease. These patients often h...

Both letermovir & maribavir can be perpetrator or victim of a drug–drug interaction
🆕️🔥 #CPK
Drug–Drug Interaction Management with the Novel Anti-Cytomegalovirus Agents Letermovir & Maribavir: Guidance for Clinicians #idsky
✨️tables✨️ #bookmark
link.springer.com/article/10.1...