Eugenio Contreras

OBS Seminar
Tregs: Friend or Foe against CRC?

👨‍🔬 @drxiaohuang.bsky.social @mskcancercenter.bsky.social - Rudensky Lab @cp-immunity.bsky.social

📣 @eugecc.bsky.social @licona-limonlab.bsky.social

🗓️ Thu , 02-026-26 8: AM PT , 11 AM ET, 4pm GMT, pm CET
👇
us02web.zoom.us/meeting/regi...

Felicidades Daniela! Me inspiró mucho siempre tu tweet donde descrbías que al regresar a México ibas "fade into mediocrity". Y todo lo contrario, tu trabajo y ciencia hablan por ti. Eres en verdad un modelo a seguir para los científicos en formación! Por muchos logros mas

Ancestry and somatic profile indicate acral melanoma origin and prognosis - Nature Analysis of the somatic and transcriptomic profile of 123 acral melanoma samples from Mexican patients helps understand tumour origins and prognosis, and highlights the importance of including samples...

We are very happy to see our study finally appear online @nature.com! This has been work of nearly 10 years in collaboration with the National Institute of Genome Medicine 🇲🇽, the National Cancer Institute 🇲🇽, the @sangerinstitute.bsky.social and others ⬇️

www.nature.com/articles/s41...

Tumour-brain crosstalk restrains cancer immunity via a sensory-sympathetic axis KrasLSL−G12D/+; p53fl/fl (KP) mice have been described previously55. KP mice were crossed with Rosa26LSL−tdTomato mice to generate KP; LSL-tdTomato mice. Wild-type C57BL/6 J, Trpv1-cre, Rosa26LSL−DTR (LSL-DTR), Vglut2-cre, Baf53b-cre, Pparγfl/fl and CD11c-cre mice were purchased from The Jackson Laboratory. Trpv1-cre and...

Tumour-brain crosstalk restrains cancer immunity via a sensory-sympathetic axis
->Nature | More on "Brain tumor immune system interaction" at BigEarthData.ai

Amazing work! Congratulations

Very happy to share our new study defining the ontogeny of Thetis cells and the developmental cues that shape their early-life wave of differentiation. www.nature.com/articles/s41... Beautiful work led by @hhmi-science.bsky.social Gilliam Fellow Yoselin Paucar Iza and postdoc Tyler Park 1/

Some of your cells are not genetically yours — what can they tell us about life and death? A tiny population of cells that are passed across the placenta between mother and baby challenge basic tenets of human immunology.

@nature.com book review by @babiesresearch.bsky.social on book Hidden Guests
Some of your cells are not genetically yours — what can they tell us about life and death? nature.com/articles/d41...
greystonebooks.com/products/hid...

🎙️ OBS Speaker Highlight

👩🔬 Alejandra Mendoza @scripps.edu @science.org @mskcancercenter.bsky.social

📌 Registration
👉https://us02web.zoom.us/meeting/register/PAhTFIZIR8qQ4Jj0UrUWQA#/registration

🔥 We’re starting the year strong with Treg Immunology! 🔥

Congratulations to Drs. Jose Villadangos and Hamish McWilliam's (@hay-mish.bsky.social) labs on their @science.org paper!

Their teams at the Doherty Institute showed that #macrophages are key for MR1 antigen presentation and MAIT cell immunity.

🗒️ https://bit.ly/49W1GW1
🎤 https://bit.ly/44Ay1OG

Excited to share our new study, the paper is out today @cp-immunity.bsky.social! Not all Treg cells are the same. We identified two Treg cell subsets with opposing functions in colorectal cancer (CRC). 1/8

Melanoma cells escape immune surveillance by releasing MHC-antigen-loaded melanosomes that directly engage and impair CD8+ T cell receptors @cellcellpress.bsky.social @weizmanninstitute.bsky.social @ragoninstitute.bsky.social
www.cell.com/cell/fulltex...

Intravital observation of neuronal and immune cell dynamics in the developing mammalian brain @cellcellpress.bsky.social
www.cell.com/cell/fulltex...

Distinct components of mRNA vaccines cooperate to instruct efficient germinal center responses This study dissects the individual contributions of the different components of mRNA vaccines to immune responses. Nucleoside-modified mRNA promotes the production of type I interferons that act on de...

I am excited to share that our work, in which we have dissected the signals driven by the nucleoside-modified mRNA and LNP components of mRNA vaccines that regulate germinal center (GC) responses, is now published in Cell! www.cell.com/cell/fulltex...

Opposing functions of distinct regulatory T cell subsets in colorectal cancer Huang et al. study the heterogeneity of regulatory T (Treg) cells in a genetic model of colorectal cancer (CRC) and find that interleukin (IL)-10− Treg cells promote tumor progression, whereas IL-10+ ...

Mind-blowing 🤯 IL-10⁺ Tregs restrain tumor growth?! Maybe it’s time to rethink “immunosuppressive cytokines” ; their function clearly depends on the inflammatory milieu. @mskcancercenter.bsky.social @cp-immunity.bsky.social www.cell.com/immunity/ful...

Generating functionally stable and antigen-specific Treg cells from effector T cells for cell therapy of inflammatory diseases Antigen-specific and functionally stable Treg cells can be generated in vitro from effector/memory T cells for cell therapy of inflammatory diseases.

Kyoto University scientists converted ordinary T cells into stable regulatory T cells that can suppress autoimmune disease in mice.

This approach may enable personalized, targeted cell therapy for inflammatory diseases.

www.science.org/doi/10.1126/...

REFLEX, a Novel Immune Profiling Assay, Combining TCR Repertoire and Multiome at Massively Scalable Single-cell Resolution to Catapult Exploration of T-cell Derived Immunity https://www.biorxiv.org/content/10.1101/2025.10.24.684243v1

Temporal and context-dependent requirements for the transcription factor Foxp3 expression in regulatory T cells @natimmunol.nature.com @yuripritykin.bsky.social Rudensky @princetonupress.bsky.social @mskcancercenter.bsky.social www.nature.com/articles/s41...

The vaccine we all wear: Skin microbiota can be engineered into topical vaccines Skin microbiota can be engineered into topical vaccines

How basic research at the interface of #immunology and #microbiology leads to potential new #vaccines that could be applied on the skin. Favorite sentence: "We applied bacterial cultures to the heads of mice by gently rubbing their skin with a swab."
www.science.org/doi/full/10....

🌿🔬 Call for Papers: Ecoimmunology Special Collection

Explore how ecological factors shape immune responses in humans & animals - from wild systems to lab models.

🧪 Submit your work: bridging ecology + immunology!

📖 https://bit.ly/44N141N

#Ecoimmunology #Immunology

The Nobel Prize in medicine goes to 3 scientists for work on peripheral immune tolerance Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi have won the Nobel Prize in medicine for their discoveries about peripheral immune tolerance.

BREAKING: Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi win the Nobel Prize in medicine for work on peripheral immune tolerance.

"[Verena Van Der Heide] Finite antigen exposure drives reversible defects in ‘helpless’ CD8+ T cells Verena Van Der Heide, (Icahn School of Medicine at Mount Sinai ) Prolonged but finite antigen presentation promotes reversible defects of ‘‘helpless’’ memory CD8+ T cells (Immunity 2025)

youtu.be/ArQgwaqwpW4
Verena Van Der Heide talk is now on Youtube!
Prolonged but finite antigen presentation promotes reversible defects of ‘‘helpless’’ memory CD8+ T cells. @ ImmunityCP @SinaiImmunol @LCMVlab

My lab with Dr Miriam Merad @Miriammerad at the national congress of the Mexican Society of Immunology 🥰 It was an honour to have the chance to meet such an inspiring leader in immunology

Welcome! You are invited to join a meeting: OBS Immunology Seminar . After registering, you will receive a confirmation email about joining the meeting. Help Wanted: CD4⁺ T Cells as Architects and Rescuers of CD8⁺ T Cell Responses Verena Van Der Heide, (Icahn School of Medicine at Mount Sinai ) Prolonged but finite antigen presentation promotes reversible...

OBS Seminar: Neuroimmunology
👩🔬 Sara Trabanelli University of Geneva
"Neural anticipation of virtual infection triggers an immune response"

🗓️ Thu 25th September7:00 AM PDT 10:00 AM EDT 2:00 PM GMT 4:00 PM CEST

👇 Registration:
us02web.zoom.us/meeting/regi...

OBS Immunology Seminar

👩‍🔬 Verena Van Der Heide,
Icahn School of Medicine at Mount Sinai @cp-immunity.bsky.social
👩‍🔬 @valentinavenzin.bsky.social @iannaconelab.bsky.social @unisr.bsky.social @pasteur.fr

🗓️ Thu, September 4th, 11 AM EDT, 3 pm GMT, 5 pm CET

👇
us02web.zoom.us/meeting/regi...

🚫 Update: Our online seminar has been cancelled/postponed. Thanks to everyone who showed interest—we’ll share updates on future sessions here!

Phase 1 of a hypoimmune allogeneic T cell product, CRISPR deleted TRAC, PD1, HLA-A, HLA-B, CIITA, with a CD19-targeting synthetic TCR and antigen receptor in TRAC locus in 5 patients with severe, refractory #lupus nephritis @naturemedicine.bsky.social www.nature.com/articles/s41...

Anchored screening identifies transcription factor blueprints underlying dendritic cell diversity and subset-specific anti-tumor immunity @cp-immunity.bsky.social @lunduniversity.bsky.social www.cell.com/immunity/ful...

KIR–HLA Interactions Influences Cetuximab Efficacy in Colorectal Cancer
www.mdpi.com/1422-0067/26...