Ava Mackay-Smith

Join the SEPEEG meeting on Oct 3-5 in the Great Smoky Mountains to explore ecology, evolution, and genetics. It’s student-friendly! More info: https://sepeeg2025.blogspot.com/ #conference

Genome Mountaineering: Expanding Horizons of the 3D Genome for the Intrepid Evolutionary Adventurer Abstract. The physical positioning of DNA in 3D space within the nucleus can be important for understanding how genetic changes influence gene regulation a

That’s the inspiration for our title, genome mountaineering - every one of our section headers and table/figure captions are named after something mountain-related!

academic.oup.com/gbe/article/...

Thanks for reading till the end! * 7/7

#PopGen #evo #evolution #genomics #epigenomics

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If you made it this far, one of my favorite parts of writing this paper was that we kept thinking about the genome as moving from a linear representation into a series of loops and twists, almost like a mountain range. 6/7

a man in a blue shirt and tie is standing in front of a bulletin board with papers on it . ALT: a man in a blue shirt and tie is standing in front of a bulletin board with papers on it .

Because this was a Perspectives-type article, citations are limited, and we had to make some tough choices about the works we cited (this was hard!) My apologies if we weren’t able to include your work & please feel free to repost this thread to publicize your own related research! 5/7

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We hope that this Perspective sparks curiosity and acts as a low barrier for entry into this space, rather than a comprehensive review (many of which already exist and are excellent!) If you make it till the end and are hungry for more, check out Table 1 for some recommended subsequent reading! 4/7

spongebob squarepants is smiling and holding his hands up in the air with the words `` genetics '' written above him . ALT: spongebob squarepants is smiling and holding his hands up in the air with the words `` genetics '' written above him .

We focus on exploring: 1) evolutionary rates and #conservation in #comparative studies, 2) evolutionary innovation in 3D genome structure, 3) #structuralvariation and breakpoints, and 4) general principles of #generegulation as informed by 3D #genomestructure. Sound cool to you? Check it out! 3/7

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Instead of being a highly technical review, we focus on some of the conceptual questions that evolutionary biologists can investigate with these methods. We want to convince you that 3C-based genomic methods can contribute towards answering questions you’re already interested in! 2/7

🌟 paper tweetorial! 🌟 check out my first first-author paper from my Ph.D! We wrote a small (=easy-to-read) Perspective piece trying to bridge the gap between #evolutionarybiology and the expanding world of #genomic assays, specifically #chromatin conformation capture (3C and related approaches) 🧵1/7

🦋 Happening today at #BoG25:

Are you interested in unusual patterns of recombination in the context of ongoing hybridization??

If you answered yes OR no to this question, come by poster 187 tonight! Learn something, or teach me something! 🦋

🦋 If you're 1) coming to #BoG25 (!!!) and 2) like thinking about weird patterns of recombination or population genetics, come say hi & stop by my poster "Exploring hybridization persistence: Gene regulatory dynamics and sex-specific recombination landscapes in Lepidoptera" 🦋