The application deadline has been extended for a postdoc position in our lab until August 22. Please enquire/apply if you are interested in ADP-ribosylation, ubiquitination, genome stability or immunity.
my.corehr.com/pls/uoxrecru...
This isn't a coincidence, IMO. The fly community is generally super rigorous - because there are so many tools and techniques available, people expect you to really nail things in order to get published (and keep getting funded)
What my brother @aheljo.bsky.social works on nowadays :)
A postdoc position is available in our lab to study ADP-ribosylation and ubiquitylation signalling! We are looking for someone with experience in structural biology and biochemistry. The application deadline is June 20th.
my.corehr.com/pls/uoxrecru...
Happy to share a new little paper from our team - by @origichals.bsky.social et al. It describes a strategy to make SUMO1 more crystallisable by fusing it with a helper domain. Check out the nice ITC showing it still binds to SIM motifs. We are now working on co-crystallisation with SIM peptides.
A few years back we discovered a novel dual hybrid protein modification composed of ADP-ribose dinucleotide and ubiquitin (ADPr-Ub):
pubmed.ncbi.nlm.nih.gov/36197986/
Happy that my work on RNF213 has been published as a part of doi.org/10.1038/s414...!
Many thanks to all the groups involved:
@clausenlab.bsky.social
@e3chembio.bsky.social
@fletcherlab.bsky.social
Have a look at the summary from Fletcher lab for an insider perspective of the paper's history:
"If an experiment fails, our first thought is usually "did I do something wrong?"" - what's sadly often missing is asking the same question when the experiment "succeeds", i.e. gives the wished-for result. There's a severe lack of (self-)skepticism in this line of work once it gets 'exciting'. :)
