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Umut Kilik

@umut-kilik

Postdoc @ FMI Basel (Turco Lab) | Exploring endometrium regeneration & niche 🌱🩸 | Human model systems + single-cell genomics + evo-devo | Former PhD @ IHB (Camp Lab)

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23.11.2024
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Latest posts by Umut Kilik @umut-kilik

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I've started my own lab πŸŽ‰
PhD/postdoc positions available - reach out if curious about cerebellum evo-devo and autism spectrum disorders.

We’re based at Uni Tartu, Institute of Genomics (home to Estonian Biobank), and funded by @simonsfoundation.org @embo.org, and the Estonian Research Council.

29.01.2026 20:33 πŸ‘ 51 πŸ” 26 πŸ’¬ 4 πŸ“Œ 4
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Different tissue, different questions, same fascination with how cells coordinate to build and rebuild complex organs.
Excited to uncover what drives this remarkable regenerationπŸ™‚ @fmiscience.bsky.social | @P.T. Engelhorn Foundation for the Promotion of Biotechnology and Life Sciences

17.01.2026 11:47 πŸ‘ 5 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0

This fellowship will support my work using organoid models and spatial transcriptomics to understand how immune and epithelial cells communicate during this process.
Switching from evo-devo to the regeneration field has been exciting.

17.01.2026 11:47 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

Since joining Margherita Turco's lab, I've been studying endometrial regeneration, investigating how the uterine lining breaks down and rebuilds itself every month without scarring.

17.01.2026 11:47 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

Starting 2026 with some good news: I've been awarded a Peter and Traudl Engelhorn Foundation Postdoctoral Fellowship for my research at the Friedrich Miescher Institute!

17.01.2026 11:47 πŸ‘ 8 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

and @munafomarzia.bsky.social for this beautiful artwork πŸ™‚

17.01.2026 11:43 πŸ‘ 1 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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Proud to share this recognition with my co-first authors, @Stefano Secchia and @Qianhui Yu, and our supervisor, @graycamplab.bsky.social
Paper: lnkd.in/e_CaEGAS
Grateful for our collaborators who made this great teamwork possible: @Jason Spence | @Craig Lowe | @Barbara Treutlein |@Joep Beumer,

17.01.2026 11:43 πŸ‘ 1 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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The project set out to understand what makes human guts uniquely human by comparing them to our closest relatives. We created the first chimpanzee intestinal organoid models and used single-cell genomics to map the evolutionary changes that shaped human gut biology.

17.01.2026 11:43 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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A nice way to close the chapter on my PhD work: our team was awarded the Bruno Speck Award 2025 by the Swiss Foundation for Haematological Research for our publication on human intestinal evolution.

17.01.2026 11:43 πŸ‘ 7 πŸ” 2 πŸ’¬ 1 πŸ“Œ 0
A summary schematic showing morphogen gradients in the developing human embryo, an overview of two screenings performed in the study (one testing factors related to patterning conditions, another one testing factors related to patterning reproducibility) and icons representing the main readouts of the screenings: organoid cell type composition, measures of morphogen interactions, primary atlas comparison and regulon activity.

A summary schematic showing morphogen gradients in the developing human embryo, an overview of two screenings performed in the study (one testing factors related to patterning conditions, another one testing factors related to patterning reproducibility) and icons representing the main readouts of the screenings: organoid cell type composition, measures of morphogen interactions, primary atlas comparison and regulon activity.

Your new batch of cortical organoids resulted in mixed regional identities closer to hindbrain. Why is patterning so hard?😩

✨Our latest paper might help you✨
tinyurl.com/neorgpat

#morphogen #neuralorganoids #patterning #scRNAseq
@graycamplab.bsky.social @ethz.ch @nazbukina.bsky.social

19.12.2025 17:01 πŸ‘ 21 πŸ” 11 πŸ’¬ 1 πŸ“Œ 2
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πŸ“’ Please help spread the word: We’re hiring a Head of Student & Postdoc Affairs to coordinate our international PhD program, provide guidance & career counseling, lead training programs, collaborate on EDI initiatives, and manage alumni relations. Apply at www.fmi.ch/education-ca...

04.12.2025 07:23 πŸ‘ 9 πŸ” 13 πŸ’¬ 0 πŸ“Œ 2

Lab’s 1st preprint!

Menstruation is understudied due to societal taboos + a biological challenge: mice (a key system for research + drug discovery) don’t menstruate.

@cagricevrim.bsky.social made menstruating mice + used them to discover early events in menstruation.

He is on the job market!

10.10.2025 13:26 πŸ‘ 301 πŸ” 91 πŸ’¬ 18 πŸ“Œ 8
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Induction of menstruation in mice reveals the regulation of menstrual shedding During menstruation, an inner layer of the endometrium is selectively shed, while an outer, progenitor-containing layer is preserved to support repeated regeneration. Progress in understanding this co...

I’m thrilled to share my postdoc work and the first paper from the McKinley Lab! πŸŽ‰
@karalmckinley.bsky.social
We built the first transgenic model of menstruation in mice.
We used it to uncover how the endometrium organizes and sheds during menstruation. πŸ§ͺ
www.biorxiv.org/content/10.1...
🧡

10.10.2025 12:50 πŸ‘ 232 πŸ” 83 πŸ’¬ 14 πŸ“Œ 15
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Join us on November 4th!
The winners of our best short talk awards will be telling their research on the @isscr.org stage!
Thank you @stemcellreports.bsky.social for co-organizing this webinar!

08.09.2025 11:09 πŸ‘ 9 πŸ” 8 πŸ’¬ 0 πŸ“Œ 0

This is it. The act of science -like art- is not the output, it is the interaction and the process. What makes us the kind of scientists we are is how we approach the problem πŸ§ͺ

24.08.2025 19:04 πŸ‘ 73 πŸ” 14 πŸ’¬ 5 πŸ“Œ 2
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Final version @science.org "Recent evolution of the developing human intestine affects metabolic and barrier functions". Evolutionary preparation for microbiota, diet, and pathogen exposure is fascinating! Thank you @erc.europa.eu for supporting our vision!
www.science.org/doi/10.1126/...

22.08.2025 21:04 πŸ‘ 30 πŸ” 8 πŸ’¬ 2 πŸ“Œ 0
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Sharing our newest study led by the incredibly talented @federicamosti.bsky.social investigating new molecular mechanisms of human brain development. We discover a human-specific enhancer HAR1984 that influences chromatin looping to promote cortical size and folding! www.biorxiv.org/cgi/content/...

10.08.2025 13:19 πŸ‘ 91 πŸ” 33 πŸ’¬ 1 πŸ“Œ 4
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Altogether, we identify the developing human intestinal epithelium as a rapidly evolving system, and show that great ape #organoids provide insight into human biology. πŸ™Thanks πŸ™ to all authors! Especially co-first authors: @CY_Qianhui_YU @KlkUmut @stefanosecchia 11/11

24.07.2025 12:36 πŸ‘ 4 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
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Diet/microbes place the gut epithelium as a nexus for evolutionary change. With Jason Spence and Craig Lowe labs we use #organoids to explore how evolution prepared the developing human intestine for exposure to the environment. @science.org #evodevo www.science.org/doi/10.1126/... 1/11

24.07.2025 12:32 πŸ‘ 41 πŸ” 9 πŸ’¬ 3 πŸ“Œ 1

πŸ’‘ What makes humans unique beyond our brains? Grateful for my PhD mentor @graycamplab.bsky.social and generous collaborators @Jason Spence, @Craig Lowe and @Barbara Treutlein and all their lab members made this work possibleπŸ™Œ and @erc.europa.eu for funding this research!

24.07.2025 12:49 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

From Max-Planck-Institute for Evolutionary Anthropology to @eth-bsse.bsky.social to Institute of Molecular and Clinical Ophthalmology Basel (IOB) to @umich.edu to IHB, with brilliant co-first authors @Qianhui Yu & Stefano Secchia, we tackled

24.07.2025 12:49 πŸ‘ 1 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

🚨 After 7 years in the making, my PhD thesis work is finally published in @science.org 🧬✨
What does our gut say about how we became human? During my hitchhiking journey spanning 3 countries and multiple lab moves

24.07.2025 12:49 πŸ‘ 29 πŸ” 5 πŸ’¬ 5 πŸ“Œ 0
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My postdoc work at Treutlein lab and @graycamplab.bsky.social with @jasperjanssens.bsky.social is out in @science.org ! We screen for neuron subtypes using pro-neural TFs + morphogen combinations + scRNA-seq and profiled over 700,000 cells in 480 conditions. www.science.org/doi/10.1126/...

12.07.2025 22:11 πŸ‘ 83 πŸ” 23 πŸ’¬ 5 πŸ“Œ 0
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A male-essential miRNA is key for avian sex chromosome dosage compensation - Nature Birds have evolved a unique sex chromosome dosage compensation mechanism involving the male-biased microRNA (miR-2954), which is essential for male survival by regulating the expression of dosage-sens...

Our study on a male-essential microRNA and the evolution of other dosage compensation mechanisms in birds is now out in Nature! www.nature.com/articles/s41...

16.07.2025 15:23 πŸ‘ 123 πŸ” 58 πŸ’¬ 10 πŸ“Œ 6
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Recent evolution of the developing human intestine affects metabolic and barrier functions Diet, microbiota, and other exposures place the intestinal epithelium as a nexus for evolutionary change; however, little is known about genomic changes associated with adaptation to a uniquely human ...

Elegant and insightful study on gut evolution and development - congratulations 🎊@graycamplab.bsky.social @umut-kilik.bsky.social

www.science.org/doi/10.1126/...

19.07.2025 20:41 πŸ‘ 4 πŸ” 1 πŸ’¬ 1 πŸ“Œ 0

Thanks Maxime for the kind wordsπŸ™‚

20.07.2025 00:50 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Recent evolution of the developing human intestine affects metabolic and barrier functions @science.org @graycamplab.bsky.social
www.science.org/doi/10.1126/...

17.07.2025 19:23 πŸ‘ 8 πŸ” 4 πŸ’¬ 0 πŸ“Œ 0

An organoid model of the menstrual cycle reveals the role of the luminal epithelium in regeneration of the human endometrium https://www.biorxiv.org/content/10.1101/2025.07.03.663000v1

07.07.2025 10:30 πŸ‘ 8 πŸ” 4 πŸ’¬ 0 πŸ“Œ 1
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Neuron programming! Pro-neural TFs + 480 morphogen conditions + scRNA-seq --> Diverse iN subtypes of forebrain, midbrain, hindbrain, spinal cord, and PNS. @hsiuchuanlin.bsky.social‬ @jasperjanssens.bsky.social‬ and Treutlein Lab! @science.org www.science.org/doi/10.1126/... #NGN2 #ASCL1

11.07.2025 20:59 πŸ‘ 78 πŸ” 32 πŸ’¬ 4 πŸ“Œ 0

✨Exciting news!✨
The World Endometriosis Research Foundation (#WERF) – Endometriosis Phenome and Biobanking Harmonisation Project (#EPHect) today publishes #SOPs to optimize the use of experimental in vivo and in vitro models in #endometriosis research.

09.07.2025 22:28 πŸ‘ 5 πŸ” 2 πŸ’¬ 1 πŸ“Œ 0