Dylan Sosa

I’m excited to be giving an Armour seminar at the Field Museum tomorrow for Woman’s History Month! www.fieldmuseum.org/our-events/a...

Some molecular machines, like ribosomes, can persist for long periods of time in cells.

Could molecular aging of ribosomes shape how proteins are made?

In our new preprint we track ribosomes as they age in cells and uncover unexpected effects on translation (1/10)

www.biorxiv.org/content/10.6...

Ambient RNA & barcode swapping is a serious issue in single-cell genomics. Tools such as CellBender, scAR, DecontX & SoupX. We have developed CellSweep which is faster (in some cases by a lot) and much more accurate. Extensively tested and benchmarked. www.biorxiv.org/content/10.6... 1/

Looking forward to #Dros26 this week. My lab is recruiting and I would be delighted to chat with anyone interested in grad school/postdoc positions in evolutionary cell biology and developmental genetics. Please reach out if interested!

So I pleased to announce the conceptual spawn of FigTree: PearTree (acronym still to be finalised). If you want to dive right in it is hosted as a web app here: artic-network.github.io/peartree (click the “Example...” button for immediate candy and then click every button you can find).

I feel like this is a great time to remind everyone that it's not even technically wrong to say that logistic regression is machine learning

We are excited to introduce Hub Space, a new hosting service that enables users to upload and visualize track hub files directly on the UCSC Genome Browser without relying on third-party hosting services such as Dropbox, Google Drive, or AWS.

Learn more: https://bit.ly/3NTZBkq

NIH Unified Funding Strategy Objective peer review, and HHS- and NIH- specific priorities, and a standardized, transparent process for incorporating NIAID-specific priorities will guide funding selections.

New NIH funding strategy has been formalized.

I really do hope scientists understand what this means for the future of science (funding) - it's not subtle.

www.niaid.nih.gov/about/unifie...

AI has supercharged scientists—but may have shrunk science Analysis of 41 million papers finds that although AI expands individual impact, it narrows collective scientific exploration

In the largest analysis of its kind so far, researchers find that scientists embracing any type of #AI—going all the way back to early machine learning methods—consistently make the biggest professional strides. https://scim.ag/49DAlWT

ARN: nous horitzons en la medicina del futur 🧬

L’ARN és una molècula clau en la biologia cel·lular i, en els darrers anys, ha guanyat protagonisme gràcies a les vacunes basades en ARN missatger. Però el seu potencial va molt més enllà. ⬇️

Ontogeny of the spinal cord dorsal horn The dorsal horn of the mammalian spinal cord is organized into laminae where each layer is populated by different neuron types, has distinctive circuit connections, and plays specialized roles in beha...

Excited to share @rbrianroome.bsky.social ‘s beautiful paper on development of the dorsal horn of the mouse spinal cord @science.org

This is how the anatomical organization and cell types that process pain, touch, body position and more are laid down.

www.science.org/doi/10.1126/...

An expanded registry of candidate cis-regulatory elements - Nature The existing ENCODE registry of candidate human and mouse cis-regulatory elements is expanded with the addition of new ENCODE data, integrating new functional data as well as new cell and tissue types...

Our paper on the newest version of the Registry of candidate cis-Regulatory Elements (cCREs) is out 🧬

Huge thanks to the many collaborators, experimentalists, analysts and software developers who made this work possible — truly a team effort!

A "meme-torial" of the science is coming soon 👀

i agree. it's a rude technology and it deserves a rude response

We tend to emphasize the maternal role in development: an egg cell is enormous compared to a sperm cell, and a mother gestates the embryo. But a growing body of research suggests that sperm cells carry more than just genetic information. www.quantamagazine.org/how-dads-fit...

Why Humans Walk on Two Legs | Harvard Magazine Research highlights our evolutionary ancestors’ unique pelvis.

Great coverage of our work on the pelvis: www.harvardmagazine.com/research/har...

SMBE is now on Weixin/WeChat

SMBE is now on Weixin/WeChat!

Stay up-to-date with the latest news, events, and articles published in @molbioevol.bsky.social and @genomebiolevol.bsky.social

Follow the @officialSMBE account, or scan the QR code with the app.

🔗 academic.oup.com/smbejournals/pages/wechat

#society

This is an important and information rich article. I wondered about the effects by Institute. The table below (which is snipped here but is in the article) has that info. Broken down by # of grants and $ amounts.

We are thrilled to announce the first official release (v0.1.8) of #𝗯𝗲𝗱𝗱𝗲𝗿, the successor to one of our flagship tool, #𝗯𝗲𝗱𝘁𝗼𝗼𝗹𝘀! Based on ideas we conceived of long ago (!), this was achieved thanks to the dedication of Brent Pedersen.

1/n

Ichetucknee Springs State Park, a short drive from Gainesville, FL

The Hopkins Lab (hopkins-lab.com) at the University of Florida is looking to recruit a postdoc to work on the genetics of organ function and evolution across Drosophila and beyond. Please visit tinyurl.com/vcsjpmzz or email me for more info. And please RT or send to anyone who might be interested!

Mood

On this date, Matthew Shephard died 27 years ago. He was beaten, tortured, and left for dead on fence for being gay. Please keep him and his wonderful mother Judy in your thoughts. And let's all work for a world where such horrific things do not happen to anyone. ❤️🏳️‍🌈

It bears repeating that nearly the entire US enterprise in science and technology has been irreversibly gutted. This is shocking.

All this loss has occurred without any real benefit to the average US citizen. Except we now have the biggest, best funded secret police force perhaps ever.

Yay for us!

AAAAAAAHHHHHHHHHHH

Federal Court Sides With UChicago in Challenge to NSF Funding Policy A federal judge struck down the National Science Foundation’s 15 percent indirect research cost cap, calling the policy “arbitrary and capricious.”

chicagomaroon.com/48196/news/f...

a 3d rendering of a colorful dna molecule with a black background ALT: a 3d rendering of a colorful dna molecule with a black background

Happy #RNA Day everyone!!! 🎉🎉🎉

#AUG1st #RNASky

Excited to report that Joy Bergelson (bergelsonlab.org) and I will be running a brand new GRC conference on the Function of Evolving Systems in the summer of 2026. The 2028 one will be chaired by Mikhail Tikhonov (physics.wustl.edu/people/mikha...) and @asanchezlab.bsky.social! Stay tuned!

FlyBase.org release FB2025_03 is live! Go enjoy the refreshed data.

The clock-like accumulation of germline and somatic mutations can arise from the interplay of DNA damage and repair The rate at which DNA mutations accumulate varies substantially across cell types and tissues in the human body, but the origin of these differences is not well understood. This study develops a model...

Those who enjoyed the plenary talk from @mollyprz.bsky.social this morning at #SMBE2025 might like to read more about this work in this 2024 @plosbiology.org paper with @natanaels.bsky.social &co: journals.plos.org/plosbiology/...

Symposium 17: Thematic symposium: regulatory genomics and non-coding elements

#SMBE2025

My sincere thanks to @official-smbe.bsky.social for the opportunity to share my work at the grad student excellence symposium this week in Beijing ❤️‍🔥