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David Llères

@davidlleres

CNRS researcher in Marcelo Nollmann's team at Centre de Biologie Structurale (CBS) in Montpellier, France. Microscopist interested in using advanced imaging techniques (Hi-M, FRET, etc) to study 3D genome organization, gene regulation and epigenetics.

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Latest posts by David Llères @davidlleres

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🚨 Job Alert - Please share! 🙏

Interested in 3D gene regulation in development & evolution? 🤓🧬

💥 Our lab at @cabd-upo-csic.bsky.social is expanding!

We’re recruiting:
✅ PhD students
✅ Postdocs
💻🧪 Experimental or computational backgrounds welcome

👇 Details below

06.03.2026 10:14 👍 36 🔁 37 💬 1 📌 4
Flyer for symposium: https://ctrlepiedit.sciencesconf.org/

Flyer for symposium: https://ctrlepiedit.sciencesconf.org/

Very excited to announce the FIRST symposium on epigenome editing! These tools are becoming widely used in mol bio, ag & therapy. It's time to bring leaders together to discuss this rapidly growing and exciting field. And why not in Paris! Please register & share! (1/2) ctrlepiedit.sciencesconf.org

09.03.2026 13:15 👍 77 🔁 55 💬 3 📌 5

Dear postdoc fellows, interested in applying for MSCA Postdoc Fellowship with team Epi2Trans at LGDP CNRS/UPVD in Perpignan, France? Get in touch with us! #MSCA #Postdoctoral #PlantScience #Epigenetics #TransposableElements #CNRS #UPVD www.linkedin.com/in/guillaume...

16.02.2026 17:51 👍 7 🔁 5 💬 0 📌 0
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Transient histone deacetylase inhibition induces cellular memory of gene expression and 3D genome folding - Nature Genetics Acute perturbation of histone acetylation induces changes in chromatin organization that are only partially reversed once the perturbation is removed and are associated with transcriptional memory eff...

TSA treatment may induce cellular and structural memory !! Happy to have been part of this beautiful story, lead by @fpaldi.bsky.social in Giacomo Cavalli's lab. Now published in @natgenet.nature.com 👏.
www.nature.com/articles/s41...

10.02.2026 08:30 👍 19 🔁 5 💬 0 📌 1
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The Centre for Research in Cellular Biology of Montpellier (CRBM) is recruiting Junior / Senior Group Leaders - FocalPlane The Centre for Research in Cellular Biology of Montpellier (CRBM) is recruiting Junior / Senior Group Leaders to shape its research in the coming decade

'The Centre for Research in Cellular Biology of Montpellier (CRBM) is recruiting Junior/Senior Group Leaders to shape its research in the coming decade.
The deadline for application is 31st of March 2026.'
#sciencejobs
focalplane.biologists.com/cell-biology...

04.02.2026 11:52 👍 13 🔁 12 💬 0 📌 0
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Excited to share our new preprint on Myxococcus xanthus!
We show that two distinct motility motors can propel the same bacterial cell simultaneously, and that this dual propulsion is tunable by environmental calcium. 🧵 1/6

📄 Read it here →https://www.biorxiv.org/content/10.1101/2025.10.29.685086v1

31.10.2025 13:24 👍 14 🔁 6 💬 2 📌 1
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BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)

15.10.2025 12:22 👍 492 🔁 185 💬 56 📌 61

Amazing !! I tried earlier version and it was impressive ! Congrats !

15.10.2025 19:38 👍 3 🔁 1 💬 1 📌 0
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Au CNRS, les femmes en science sur le devant de la scène Au CNRS, les femmes en science sur le devant de la scène

En ce début d’automne 2025, le CNRS continue de mettre à l’honneur les #FemmesEnScience. Tandis que "La Science taille XX elles" lance sa 8e édition, CNRS Ingénierie inaugure avec "Ingénieuses" une nouvelle exposition itinérante. Et le 15/10 paraît "Les filles sont parfaites pour les sciences".

14.10.2025 05:02 👍 58 🔁 28 💬 0 📌 2

Really excited to share our latest work led by @mattiaubertini.bsky.social and @nesslfy.bsky.social: we report that cohesin loop extrusion creates rare but long-lived encounters between genomic sequences which underlie efficient enhancer-promoter communication.
www.biorxiv.org/content/10.1...
A🧵👇

24.09.2025 21:45 👍 114 🔁 52 💬 8 📌 5
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🚀 Our new paper is out @natmethods.nature.com!

Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells.

🔗 www.nature.com/articles/s41...
🧬 www.addgene.org/John_Ngo/

22.09.2025 18:27 👍 224 🔁 97 💬 6 📌 9

Fly labs — Now is the time to show some solidarity and chip in support for this vital resource!

20.08.2025 01:53 👍 49 🔁 39 💬 1 📌 1
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How do enhancer-gene contacts relate to transcription activation? In mouse embryonic stem cells, a combo of STED, oligoFISH & RNA FISH shows that 3% of Dppa3 alleles transcribe. For these, enhancers and promoters come closer (panel E). Stumberger ... Leonhardt & Harz www.biorxiv.org/content/10.1...

26.07.2025 21:36 👍 66 🔁 31 💬 1 📌 0

🚨 Postdoc wanted (🇳🇱NL based) for our exciting collaboration with the lab of Alexander van Oudenaarden @hubrechtinstitute.bsky.social in Utrecht, with collaborative visits to our lab Copenhagen 🇩🇰. We seek a computational scientist to model epigenetic inheritance, see more below 👇!

20.05.2025 10:20 👍 12 🔁 13 💬 0 📌 0
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05.05.2025 10:52 👍 2147 🔁 792 💬 15 📌 37
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TurboCas: A method for locus-specific labeling of genomic regions and isolating their associated protein interactome Regulation of gene expression during development and stress response requires the concerted action of transcription factors and chromatin-binding prot…

You can read about TurboCas here: www.sciencedirect.com/science/arti....

29.04.2025 20:24 👍 13 🔁 3 💬 1 📌 0
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Hello World! Are you passionate about epigenomics and evolution 🧪🧬🐭🐵 ? Are you looking for a postdoc in a stimulating and inclusive environment ? Look no further... We are seeking creative postdocs for our ERC project EvoEpi @igred.fr ! 👇Details👇
tinyurl.com/PostdocEvoEp...
Repost are appreciated

31.03.2025 13:26 👍 53 🔁 55 💬 2 📌 4
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Celebrating 10 years of our lab with a new preprint:
www.biorxiv.org/content/10.1...
How does enhancer location within a TAD control transcriptional bursts from a cognate promoter?
Experiments by Jana Tünnermann and modelling by Gregory Roth

29.03.2025 12:45 👍 149 🔁 58 💬 6 📌 2

36 slots for selected talks from abstracts! Join us and share your latest research!
Deadline for early registration coming up next week

28.03.2025 08:58 👍 3 🔁 9 💬 0 📌 0
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Call For Two Group Leader Positions - Strasbourg-Ville, Bas-Rhin (FR) job with IGBMC (Institut de Génétique et de Biologie Moléculaire et Cellulaire) | 12837602 The Institute of Genetics, Molecular and Cellular Biology (IGBMC) is seeking two outstanding group leaders to establish independent research teams.

Come start your lab in beautiful Strasbourg 🇫🇷 www.nature.com/naturecareer...

22.03.2025 13:50 👍 34 🔁 29 💬 1 📌 0
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Excellent keynote lecture by Susan Gasser at EpiGene3Sys @institutcurie.bsky.social.

A summary of ground-breaking work on the role of H3K9 methylation in restricting access of activators to chromatin.

In addition Susan has a track record as excellent mentor.

'People is all what it is about.'

12.03.2025 09:27 👍 15 🔁 4 💬 0 📌 0
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Pentagon abruptly ends all funding for social science research More than 90 studies on threats such as climate change, extremism, and disinformation are halted

The U.S. Department of Defense is ending all of its funding for social science research, stopping 91 ongoing studies related to threats such as climate change, extremism, and disinformation. scim.ag/4hqu6HA

10.03.2025 20:50 👍 462 🔁 371 💬 22 📌 40

Our study on how TAD boundaries actively influence the neighboring domains published today in @pnas.org: www.pnas.org/doi/10.1073/...
Exciting outcomes from this interdisciplinary genomics/biophysical modeling strategy. See the thread for the BioRxiv preprint for a summary of highlights.

10.03.2025 22:07 👍 34 🔁 13 💬 0 📌 0

#Enhancer folks, submit your abstracts and register soon! Deadlines are around the corner and there are many opportunities for short talks.

26.02.2025 06:23 👍 8 🔁 8 💬 0 📌 0
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Paper out !!🥳big thanks to all authors @marliesoomen.bsky.social @diego-rt.bsky.social @kaessmannlab.bsky.social @jonathangoeke.bsky.social @lorenzamottes.bsky.social & 'bluesky-less'

Lots of interesting new TE (& genes) biology

Data fully browsable💻 👉 embryo.helmholtz-munich.de/shiny_embryo/

21.02.2025 15:50 👍 143 🔁 53 💬 8 📌 2
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We highlighted new research from the past two years on examples of long-range gene regulation - within large TADs, across TADs, and across chromosomes - comparing mechanisms in flies and mammals 🪰❤️🐁.

www.sciencedirect.com/science/arti...

13.02.2025 12:22 👍 29 🔁 8 💬 1 📌 0
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Enseignement supérieur et recherche : le Sénat vote 630 millions d’euros d’économies, la gauche dénonce un « coup de rabot monumental » - Public Sénat La majorité sénatoriale de droite et du centre a adopté 630 millions d’économies sur les crédits de l’enseignement supérieur et de la recherche, via un amendement de dernière minute du gouvernement. L...

Un amendement pour pomper 100 millions d'euros sur la trésorerie (fonds de roulement) du #CNRS qui, c'est bien connu, roule sur l'or #ESR #budget2025

www.publicsenat.fr/actualites/e...

22.01.2025 14:22 👍 19 🔁 11 💬 2 📌 2
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Remous au CNRS autour du projet de création de labos d’excellence Suite à l’annonce de la création des « Key Labs » , le 12 décembre, par Antoine Petit, président-directeur général du CNRS, une motion de défiance appelant à leur « arrêt immédiat » et à la démission ...

www.lemonde.fr/sciences/art...

20.01.2025 14:32 👍 8 🔁 3 💬 0 📌 3
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Excited to share James Jusuf's preprint:

By integrating Micro-C with SuperRes Live-Imaging we can calibrate genomics&imaging to perform absolute quantification of looping (e.g. this loop is present 3%)

We quantify mESC 36k loops: <loops> are generally rare (2.3%)

www.biorxiv.org/content/10.1...

16.01.2025 13:35 👍 151 🔁 64 💬 6 📌 2
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L’Institut Pasteur a décidé de quitter X L’Institut Pasteur, organisme de recherche engagé depuis plus de 130 ans dans la lutte contre les maladies infectieuses, le partage des connaissances et la défense de la science, a décidé de quitter l...

L’Institut Pasteur décide de quitter X (ex-Twitter) pour rejoindre BlueSky ! 🦋
L’Institut Pasteur a pris cette décision en raison de plusieurs dérives graves constatées sur la plateforme X depuis son rachat. Rejoignez-nous pour continuer à défendre la science ! www.pasteur.fr/fr/espace-pr...

16.01.2025 09:18 👍 291 🔁 70 💬 16 📌 6