🧵 New preprint from our group, in collaboration with the @marcbuhler.bsky.social lab at FMI Basel and the Thalassinos lab at UCL. A long project and a finding we're really pleased with. Thread 👇
www.biorxiv.org/content/10.6...
Our Lab is searching a postdoc for an exciting ERC-funded project that will start this summer. Apply if you’re passionate about multi-omics, cutting-edge computational approaches, and exploring biological questions across the animal 🪼 🪱 🐞 🦎 🦋 🕷️ tree of life www.biozentrum.unibas.ch/open-positio...
💫 We're hiring! The Computational Biology Facility is looking for a Computational Proteomics Scientist to collaborate on cutting-edge proteomics projects, develop new analytical approaches, and publish impactful research.
Apply by April 12 at: www.fmi.ch/education-ca...
Job opening for one of the most important positions at our institute.
We are hiring-join us!
Kudos to @aheljo.bsky.social and the entire team for this important contribution to our mechanistic understanding of chromatin repression by the ChAHP complex. 🧬👏
In conclusion, we propose that ChAHP represents a functional module that enables sequence-specific targeting of chromatin remodeling activity to counteract the binding of other chromatin regulators.
ADNP binding to chromatin is independent of CHD4, and CHD4’s ATP-dependent remodeling activity is not required for its recruitment to these sites. Instead, CHD4 functions to restrict the access of other TFs, such as CTCF, to ChAHP target sites.
The prevailing view is that chromatin remodelers promote transcription factor (TF) binding by making chromatin more accessible. However, this paradigm is reversed in the case of the transcription factor ADNP and the chromatin remodeler CHD4 within the ChAHP complex.
Novel insights into the silencing of an understudied transposable element - check out our latest preprint by @jakobschnabl.bsky.social and colleagues
This work is not only an amazing resource for the community, it is also a total masterclass in code reusability, data FAIRness and reproducibility. Hopefully, this is the future!
The realignment of research in our group @fmiscience.bsky.social is beginning to bear fruit. Proud of our captain @merleskribbe.bsky.social and the whole team!
www.sciencedirect.com/science/arti...
Event poster for the 2025 TriRhena Gene Regulation Club in Strasbourg in Feb. 5. Listing the schedule, you can check here: https://www.ie-freiburg.mpg.de/gene-regulation-club
We are super excited. The 1st #TriRhena Gene Regulation Club in 2025 will take place this Feb. 5th at @igbmc.bsky.social in Strasbourg.
Organizer: @marcbuhler.bsky.social (@fmiscience.bsky.social), @tomsextonlab.bsky.social (IGBMC) & Nicola Iovino (MPI-IE):
www.ie-freiburg.mpg.de/gene-regulat...
📣 Please share: We’re hiring a tenure-track Group Leader in Multicellular Systems to explore the molecular and cellular mechanisms driving the formation, maintenance, or destabilization of tissues, organs and organisms. Apply at: www.fmi.ch/education-ca...
An Essential Bookmark for Your Web Browser
data.fmi.ch/TFexplorer/ 🌐
