Philip Ruthig

Be my colleague! :)

Crude oil prices, showing a very sharp increase in the last day, from around 65 to 101 dollars per barrel..

Oil prices wouldn't be all over the news today if more of our economy was powered by local, secure renewable energy.

This isn't an "energy crisis". It's a fossil fuel crisis.

44% of UK electricity came from renewables in 2025. More of that plus an electrified economy => no more oil shocks.

holy shit

❤️ A cleared guinea pig heart for #3DThursday! Clearing a heart is HARD — dense muscle, deep antibody labeling, big volume. But to understand coronary networks, you need the whole organ.

🔬: Miltenyi Ultramiscroscope
🥼: Pam Rios Coronado, @pamrc.bsky.social
🏛️: Red-Horse lab @stanford.edu
🎬: #syGlass

For the record, an earlier version of this post, using Fig 1 from this paper, but without shorts, fell foul of BlueSky's "Adult Content" filter.

Come work with a great team on one of the big questions at Helmholtz Munich!

@helmholtzmunich.bsky.social

X/Twitter's rough full volume is around 500 total million posts every day, or 182 (and a half) billion posts per year.

By contracts, we found 11.2 million research posts in all of 2025 on there.

In other words, 0.000006% of Twitter appears to be sharing research. Basically zero.

Nanocarrier imaging at single-cell resolution across entire mouse bodies with deep learning - Nature Biotechnology An integrated experimental and deep learning pipeline reveals cell-level targeting of nanocarriers in whole bodies.

Very cool paper in NBT from the Dietz and Erturk labs @erturklab.bsky.social @markuselsner.bsky.social go.nature.com/4gNLjeC

Congratulations to our scientist, Laurent Simons, for earning his PhD in quantum physics at just 15—an exceptional achievement.

In our lab, Laurent’s work focuses on in silico biology to accelerate treatment of devastating diseases. We’re thrilled to have him on the team.

Super interesting concept!

We are introducing LipiGo 🤗
A programmable DNA–lipid nanocarrier 🧬 with built-in targeting logic. It de-targets the liver and redirects mRNA delivery into lymphoid organs, enhancing therapies requiring the immune system. Precision delivery at the cell level isn't far! www.biorxiv.org/content/10.1...

Promotional poster for the LMU Open Science Center Summer School 2025 Public Lecture. The poster features a photo of speaker Prof. Dr. Richard McElreath. The text states the lecture focuses on science as amateur software development, time and date of lecture being 9:00-10:00 CEST on Wednesday September 17 2025, and instructions to register online. Logos of LMU Open Science Center, LMU, and Universitätsbibliothek München are displayed at the bottom.

💡 Explore how practices from distributed, open-source software can make science more professional, open, and collaborative! Attend the “Science as amateur software development” lecture by Prof. Dr. @rmcelreath.bsky.social on Wed 17 Sept, 9:00.
👉 Register here: www.pretix.osc.lmu.de/lmu-osc/OSSS...

Wrote the same thing as a tweetorial on X, got a single interaction with the tweet. I guess it is finally time to leave that place for good

😱

Arrangement of raw data, semantic, and instance segmentation of human corpus callosum fibers, acquired by transmission electron microscopy. The data used for this image were generated by Maria Morozova, David Edler von der Planitz, and Philip Ruthig. All cover Art was created by the MPI for Human Cognitive and Brain Sciences Graphics department (Andrea Sandmann)

#Myelination enables faster signal propagation in the brain, but takes more energy & space. @philipruthig.bsky.social &co reveal how short- & long-range #WhiteMatter fibers differ, showing how these variations affect neural communication & processing efficiency @plosbiology.org 🧪 plos.io/4mq5tOy

That leaves me to thank my excellent co-1st author David Edler von der Planitz, and our collaborators and co-supervisors @siawooshmr.bsky.social, @nikweiskopf.bsky.social, Evgeniya Kirilina, and Markus Morawski!

A collaborative project of @mpicbs.bsky.social and @unileipzig.bsky.social!

That concludes the skeetorial - check the full paper @plosbiology.org: plos.io/4mq5tOy

Furthermore, we supply other scientists with the necessary functions that describe our experimental data - important for anyone who might want to simulate brain-wide activity!

Based on this anatomical data, we estimate that corpus callosum fibers conduct signals ~25% faster than short white matter fibers, and show a higher portion of very fast fibers (>8m/s).

In contrast, the g-ratio distribution of both sets of fibers is almost identical!

Additionally, both groups of fibers seems to have a large amount of fibers near the g-ratio of 0.6. This seems to be the equilibrium for long fibers where energy expenditure by the organism, space constraints, velocity and efficiency of signal transduction meet.

We fitted a generalized extreme value function (GEV) to all of the distributions and found that both axon diameter and myelin thickness is downscaled in shorter fibers.

Using a fully automated deep learning analysis, we segmented each structure in the TEM data and analyzed the axonal diameter, myelin thickness, and g-ratio (ratio between axon radius & myelin thickness).

To investigate this issue, we sampled white matter tissue from body donors from a variety of superficial white matter (mostly short fibers) and corpus callosum areas (very long fibers), and prepared them for transmission electron microscopy.

How are human brain regions connected? Are the connecting axons thicker and more myelinated the longer these connecting fibers are?

In our recent paper we find that indeed, they are! Read the skeetorial below ⬇️⬇️⬇️

plos.io/4mq5tOy
#neuroscience #neuroskyence #whitematter #deeplearning

Out now in @plosbiology.org: our recent study on white matter myelination and axon diameters in long and short fibers of humans! Skeetorial coming soon :)

When a microscope facility user asks about how to make a red/green overlay

Our spin-off company is hiring a COO. (Stay tuned for more job offers)

www.linkedin.com/jobs/view/42...

bsky.app/profile/matt...

Screenshot of the PDF available at https://cloud.gerbi-gmb.de/s/6LrYfMByymPnHP5/download/2025_OME-Zarr_sw_developer.pdf

Screenshot of the PDF available at https://cloud.gerbi-gmb.de/s/y4rBGFM6dXn8Jkr/download/2025_OME-Zarr_web_developer.pdf

🚀 We’re hiring again! Join @gerbi-gmb.de as a Software Developer!

💻 Build scalable #bioimaging solutions

🌍 Collaborate globally

🎯 Contribute to open science through #OME #Zarr

📣 Tell your #NGFF friends.

Remote, full-time. Apply by 30 June 2025: All submissions via bit.ly/gerbi-jobs-2...