The Henrique ⌬

Visual representation of a new trial that assessed the safety of engasertib, an oral, once-daily AKT1 and AKT2 inhibitor in development to prevent bleeding in patients with hereditary hemorrhagic telangiectasia.

No therapies are licensed to treat hereditary hemorrhagic telangiectasia, despite the considerable disease burden. Research findings with the AKT1 and AKT2 inhibitor engasertib are summarized in a new Quick Take video. nej.md/43PdHc1

#MedSky #Hematology

Mind-reading devices can now predict preconscious thoughts: is it time to worry? Ethicists say AI-powered advances will threaten the privacy and autonomy of people who use neurotechnology.

Colocaram implantes cerebrais em uma mulher que perdeu os movimentos e agora ela consegue tocar piano só com os impulsos nervosos enquanto ela imagina tocar. Muito legal.

O twist: os eletrodos lêem os impulsos antes de serem registrados pela consciência. Então ela sente que o piano toca sozinho.

Por uns anos talvez eu tenha esquecido quem eu era e o meu maior sonho, mas também eu percebi que não precisava ficar concentrado em apenas 1 sonho ou apenas 1 plano, poderia ter mais focos na minha vida...
Porém, agora tá tudo meio confuso.. Sei lá..

The big problem is that: You only live once

A-ha sempre sendo a melhor companhia das manhãs 😊

Preciso melhorar minha conversão em inglês pra ontem, no entanto, todavia... estou sem dinheiro 😭

Erythrocyte invasion in malaria: from molecular mechanisms to rational vaccines - Nature Reviews Microbiology If erythrocyte invasion is blocked during the blood stage of infection by Plasmodium parasites, malaria can be prevented. In this Review, structural insights on erythrocyte invasion by the merozoite form of Plasmodium are discussed in the context of rational design of a blood-stage malaria vaccine.

Blocking erythrocyte invasion during the blood stage of Plasmodium infection can prevent malaria. A Review in Nature Reviews Microbiology discusses structural insights on this invasion by the merozoite form of Plasmodium to aid rational design of a malaria vaccine.
go.nature.com/4o6prP4 🔒

Uma tarde toda hoje apenas para análise de RMN
Meu lob occipital que aguente

Foda!!!!

Já tô enviando compostos para serem testados em SP 😭
Favela vencendo

Depois de 3 semanas sem RMN, o dito cujo voltou.. agora tô com milhares de amostras e a ansiedade no céu para saber se todas as reações funcionaram
😭😭😭

Berkeley domina o Nobel… Lá que tem o verdadeiro suco, será??

Maybe hurt… maybe broken…

Kkkkk aaah boa…

Fazendo corujão no lab???

O cérebro do brasileiro precisa ser estudado (sério) - Podcast Não Ficção YouTube video by Atila Iamarino

What an amazing podcast with Dr. Zimmer! So much discussion about Brazilian brains and neuroscience. I'm so excited to know that science is being done at this level in Brazil.

youtu.be/WJw-XW9ZJC0?...

My spider sense is so confusing now... It's not common.

a man wearing a red shirt with the word flash on it ALT: a man wearing a red shirt with the word flash on it

Nobel prize segunda feira

Targeting prostaglandin E2 receptor 2 in Schwann cells inhibits inflammatory pain but not inflammation - Nature Communications Non-steroidal anti-inflammatory drugs (NSAIDs) are known to alleviate pain by reducing inflammation. To the contrary, here, the authors show that selective inhibition of the prostaglandin E2 receptor (EP2) in Schwann cells eliminates pain without disrupting the protective and healing functions of inflammation.

NSAIDs are known to alleviate pain by reducing inflammation. A study in Nature Communications shows that selective inhibition of the prostaglandin E2 receptor in Schwann cells eliminates pain without disrupting the protective and healing functions of inflammation. #medsky 🧪

Parece que quando meu cérebro percebe momentos de alegria, o mesmo tenta fazer uma análise de como estragar no dia seguinte... E então, repentinamente, um vazio..

Triste que no twitter não se consegue mais desabafar...
Maaas, aproveitando o espaço daqui:

Não sei que cargas d'agua o meu humor vem oscilando de alegria a tristeza profunda em um período muito curto.. Isso tá me fazendo muito mal!!

Structure–Activity Relationships of Inactive‐Conformation Binding EGFR Inhibitors: Linking the ATP and Allosteric Pockets EGFR inhibitors can be made especially effective through binding small-molecule inhibitors that target the allosteric pocket. Structural and functional analysis affords new insights into the composit....

Structure–Activity Relationships of Inactive‐Conformation Binding EGFR Inhibitors: Linking the ATP and Allosteric Pockets - Chitnis - 2025 - Archiv der Pharmazie - Wiley Online Library onlinelibrary.wiley.com/doi/10.1002/...

Foi tooooop

As well as the main classes of compounds studied in live models to try to stop AChE.

One of the key conclusions was that the most promising compounds evaluated follow the pharmacophore model of donepezil.

Evidence of the Efficacy of Acetylcholinesterase Inhibitors in In Vivo Studies: A Systematic Review Introduction: This systematic review aimed to provide an updated overview of studies using anticholinesterases with in vivo activity for the treatment of Alzheimer's disease. Methods: A systematic re...

A systematic review highlighting the most common methods for studying the action of potential compounds against Alzheimer's disease in rodents.

The findings show the most common substance or method used to damage the AChE pathway in rodents.
www.eurekaselect.com/article/150112

#MedChem #ChemBio 🧪

Are you an enthusiast of #ChemBio? Do not miss the chance to register for free for the 5th Virtual @chembiotalks.bsky.social on September 30th!
web.cvent.com/event/60e9f3...

#ChemSky #DrugDiscovery #Webinar

isso é muita loucura..

I see this researcher and imagine "how is it possible to publish more than five hundred articles???"

Profiling and Optimizing Targeted Covalent Inhibitors through EGFR-Guided Studies Targeted covalent inhibitors (TCIs) are actively pursued in drug discovery due to their prolonged target engagement and clinical efficacy. Although kinetic parameters provide a path to their optimizat...

New paper out today in J. Med. Chem. pubs.acs.org/doi/10.1021/...

Depois de um longo tempo, bateu saudade do Bsky...