Tatsuo Fukagawa

Diversity in mechanisms for epigenetic specification of vertebrate centromeres:
Tetsuya Hori, @tatsuofukagawa.bsky.social et al show that HJURP-dependent CENP-A deposition in chicken DT40 cells requires both Mis18 complex and CENP-C
link.springer.com/article/10.1...

Dual pathways via CENP-C and Mis18C recruit HJURP for CENP-A deposition into vertebrate centromeres - The EMBO Journal Centromere position is specified and maintained by sequence-independent epigenetic mechanisms in vertebrate cells, with the incorporation of the centromere-specific histone H3 variant CENP-A into chro...

Our renent paper on CENP-A deposition was just out in EMBO J. Please check it out. Congrats Tetsuta! link.springer.com/article/10.1...

40 years of CENP-A: the foundation of a new era of centromere biology - Chromosome Research Chromosome Research -

Put together by Simona Giunta, @tatsuofukagawa.bsky.social, @roneilllab.bsky.social and myself. Big thanks to all the authors who contributed to this collection!
link.springer.com/article/10.1...

KIF18A promotes chromosome congression in cooperation with CENP-E downstream of CENP-C Miao et al. demonstrate that KIF18A depletion causes synthetic defects with CENP-C hypomorphic mutant and KIF18A functions for chromosome congression in cooperation with CENP-E. CENP-E levels at kinet...

Our new paper was just out. CRISPR screening with a CENP-C mutant reveals that KIF18A and CENP-E are coordinately involved in chromosome congression. We also find that cancer cells with low levels of CENP-E are sensitive for KIF18A inhibition. Congrats Jiahang Miao!
www.cell.com/cell-reports...

I just started Bluesky.