Jessica Lehoczky

Mouse digit AAV gene delivery into fibroblasts regulates regenerative outcome AAV delivery of putative proregenerative genes into proximal, nonregenerative mouse digit fibroblasts induces regeneration.

It’s finally out!! Congrats @vivijou.bsky.social
www.science.org/doi/10.1126/...

Mouse digit AAV gene delivery into fibroblasts regulates regenerative outcome The distal mouse digit tip regenerates post-amputation, while the proximal digit undergoes fibrosis. This study presents a comparative single-cell RNA sequencing-based analysis of regenerating and non...

Congratulations to Vivian who is now officially Dr. Jou!!!
@vivijou.bsky.social

Check out our newest preprint showcasing the AAV delivery technique Vivian developed for the mouse digit. Spoiler alert: she shows AAV delivery of single candidate genes can modulate fibrosis and regeneration!

Our preprint is out! Kudos to @josanesousa.bsky.social, @gabrielalima19.bsky.social, @perezlouise.bsky.social and undergraduate prodigy Hannah Shof! By comparing Polypterus fin and axolotl limb we find shared and new regeneration programs. @lsuscience.bsky.social
www.biorxiv.org/content/10.1...

Do you have experience in generating transgenic tools and fluorescent markers? Are you interested in developing new tools in a non-conventional model, to observe and genetically manipulate cells during leg regeneration? We are recruiting!

www.averof-lab.org/pages/3560

Interested in regeneration? Consider joining the ISRB community! Details below.