PhoenixMiaoLab@UChicago

Glad to see that the art depicting our new paper is selected as the Cover for this new issue of Cancer Cell by Cell Press! First cover story of my career!

Happy New Year 2026! 🎉 Our January issue is out now: www.cell.com/cancer-cell/...

SOX2Hi tumor-initiating stem cells reprogram neutrophils that block IFN-induced reprogramming after immunotherapy, maintaining their pro-tumor phenotype at the tumor-stroma interface @cp-cancercell.bsky.social
www.cell.com/cancer-cell/...
www.cell.com/cancer-cell/...

Disarming cancer stem cells' shield makes immunotherapy more effective - UChicago Medicine Researchers at the University of Chicago revealed that a small group of cancer cells, known as tumor-initiating stem cells (tSCs), hijack nearby neutrophils, turning them from attackers into protector...

Press release for our new work
www.uchicagomedicine.org/forefront/ca...

Tumor-initiating stem cells fine-tune the plasticity of neutrophils to sculpt a protective niche The heterogeneous nature of tumor-associated neutrophils (TANs) has been recognized, but how different cell states of TANs emerge, evolve, distribute,…

Thrilled to share the new work published on @cp-cancercell.bsky.social
from our lab reporting the critical roles of tumor initiating cells in shaping the cell states of tumor associated neutrophils. sciencedirect.com/science/arti...

Looking to launch your faculty career during these turbulent times? Join Ben May Dept for Cancer Research and University of Chicago. With the strong support, this is the ideal place to start your journey! #CancerResearch
Please apply apply.interfolio.com/169039

TODAY WE ALL MARCH FOR SCIENCE!

UChicago names Jeffrey Rathmell, PhD, as Chair of the Ben May Department for Cancer Research Rathmell, a pioneer in immune and cancer cell metabolism research, has been named Chair of the Ben May Department for Cancer Research and Director of the Ludwig Center for Metastasis Research at the U...

Thrilled to have Jeffrey Rathmell, PhD, as our new chair! The future of our department is bright and strong!

Congratulations!

Could you please add me? Thanks a lot!

Thanks!

Could you please add me as well? Thanks a lot for all the effort!

I'd love to join this awesome group!

Adaptive Immune Resistance Emerges from Tumor-Initiating Stem Cells A subset of TGF-β-responsive squamous cell carcinoma stem cells are refractory to immunotherapy via expression of CD80, leading to dampening of cytotoxic T cell responses, and these tumor stem cells a...

Our recent work demonstrating the superior immune resistance that is rooted in a subset of cancer stem cells.
Adaptive Immune Resistance Emerges from Tumor-Initiating Stem Cells cell.com/cell/fulltex...

Stemness in solid malignancies: coping with immune attack - Nature Reviews Cancer Immunotherapy shows promise in treating cancers by engineering T cells or using antibodies to activate them. However, cancer stem cells (CSCs) resist immunotherapies and drive cancer relapse. In this ...

Thrilled to share our latest review with
@JudithAgudo1
on the unique immune resistance mechanisms of #CancerStemCells in solid tumors! Explore how these insights are reshaping cancer therapy approaches. #Immunology #CancerResearch #CancerImmunotherapy"
www.nature.com/articles/s41...

CD80 on skin stem cells promotes local expansion of regulatory T cells upon injury to orchestrate repair within an inflammatory environment Following tissue damage, epithelial stem cells (SCs) are mobilized to enter the wound, where they confront harsh inflammatory environments that can im…

Our new work is published on Immunity today. We have unveiled a surprising role of epithelial stem cells in mounting a robust Treg response to build a temporary and protective niche during wound repair.
sciencedirect.com/science/arti...