Cyril Anjou

Evolution and diversity of oxidoreductases involved in redox balance and energy conservation - Nature Ecology & Evolution HORBEC are protein complexes involved in the regulation of redox balance and energy conservation. The authors develop a bioinformatic tool for HORBEC annotation in bacterial and archaeal genomes and r...

Passioned by #bioenergetics? Do not miss our new article on the evolutionary history of oxidoreductases with G. Borrel and @sgribaldo.bsky.social @archaeal.bsky.social @valdeanda.bsky.social @pasteur.fr @cnrs.fr @cnrsbiologie.bsky.social @natecoevo.nature.com (www.nature.com/articles/s41...).

Cyril Anjou, 2e candidat au prix de thèse nous a présenté ses travaux sur les rôles physiologiques des systèmes thioredoxine de Clostridioides difficile, impliqués dans les étapes du cycle de vie de la bactérie, ainsi que sur l’intérêt thérapeutique potentiel de la modulation de leur expression.🦠

🦠 Mycobacteria aren't just tough, they're interior designers! 🦠 Check out our latest #preprint 🚨, led by our PhD student @camimille.bsky.social , where we show that #Mycobacterium tuberculosis builds secret cytoplasmic membranes to adapt its metabolism and sneak past immunity 🤫

Thread coming soon!

Check out @julielebris.bsky.social’s thread on our latest manuscript describing phenotypic heterogeneity in capsule production in Klebsiella & Acinetobacter @klebclub.bsky.social

This work started when I was still in @pasteur.fr & got finished in @cbitoulouse.bsky.social
#microsky #phagesky

Serotype swapping in Klebsiella spp. by plug-and-play Understanding how complex, multi-gene systems evolve and function across genetic backgrounds is a central question in molecular evolution. While such systems often impose costs through epistatic inter...

How complex functions, with important physiological and evolutionary impacts get repeatedly and efficiently transferred across genomes?
That’s what we explored using one of the fastest-evolving loci in Bacteria: the capsule locus.
The paper: www.biorxiv.org/content/10.1...
Thread👇

Phenotypic heterogeneity of capsule production across opportunistic pathogens | mBio The polysaccharidic capsule is present in ~50% of species across the bacterial phylogeny, including all ESKAPE microorganisms, the six most significant multidrug-resistant (MDR) nosocomial pathogens. It is also an important virulence factor and a major ...

Delighted to share our recently published work!
Ever wondered how Klebsiella (and others) deals with capsule production’s costs ?
The paper: journals.asm.org/doi/10.1128/...
Thread👇

Ready for the second day of the Clostpath25

#phagesky

I am looking for phages infecting Streptococcus pneumoniae to test a phenotype - does anyone have some and willing to share ?

Repost appreciated :)

I'm going to be advertising for a few positions in my group in the next couple of months for a big project on synthetic microbial communities.

I would love to hear from you if you are interested and I'd also appreciate if everyone could share this far and wide!

Reconsidering the microbial origins of primary sclerosing cholangitis and related autoimmune disorders: A case for the antro‐duodenal microbiome | Request PDF Request PDF | On Aug 5, 2025, Richard Kellermayer and others published Reconsidering the microbial origins of primary sclerosing cholangitis and related autoimmune disorders: A case for the antro‐duod...

Location in the digestive tract matters!

💩 microbiota ≠ duodenal microbiota

As our understanding of the effect of the #microbiome in #PSC grows, it beomes more nuanced.

#LetsBeatPSC
#primarysclerosingcholangitis

🔬Calling all microbiologists. 🔬 Ever feel like your paper is too small for some journals, but too solid to sit on?
#FEMSMicrobes welcomes well-executed microbiology manuscripts, and they put special attention on promoting ECR authors, eg the webinar below. 👇 @femsjournals.bsky.social @femsmicro.org

Scihub stopped uploading new articles. SciDB is a continuing effort which has the entire scihub collection AND new papers.

annas-archive.org/scidb

The role of the enteric nervous system in the pathogenesis of Clostridioides difficile infection Nature Reviews Gastroenterology & Hepatology, Published online: 22 May 2025; doi:10.1038/s41575-025-01071-xThis Perspective highlights emerging evidence of an interaction between Clostridiodes difficile and the enteric nervous system (ENS) during infection, discussing underlying mechanisms and how the ENS and extrinsic innervation are affected by C. difficile infection and toxins and how ENS responses contribute to pathogenesis and disease outcomes.

New online! The role of the enteric nervous system in the pathogenesis of Clostridioides difficile infection

#rnasky #microsky

Unique growth and morphology properties of Clade 5 Clostridioides difficile strains revealed by single-cell time-lapse microscopy by John W. Ribis, César Nieto, Nicholas V. DiBenedetto, Anchal Mehra, Pola Kuhn, Qiwen Dong, Irene Nagawa, Imane El Meouche, Bree B. Aldridge, Mary J. Dunlop, Rita Tamayo, Abhyudai Singh, Aimee Shen Clostridioides difficile is a gastrointestinal pathogen of both humans and agricultural animals and thus a major One Health threat. The C. difficile species consists of five main clades, with Clade 5 currently undergoing speciation from Clades 1–4. Since Clade 5 strains are highly prevalent in agricultural animals and a frequent cause of zoonotic infections, these strains may have evolved phenotypes that distinguish them from Clade 1–4 strains. Here, we compare the growth properties of Clade 5 strains to those of Clade 1–4 strains using anaerobic time-lapse microscopy coupled with automated image analysis. Our analyses indicate that Clade 5 strains grow faster and are more likely to form long chains of cells than Clade 1–4 strains. Using comparative genomic and CRISPRi analyses, we show that the chaining phenotype of Clade 5 strains is driven by the orientation of the invertible cmr switch sequence, with chaining strains exhibiting a bias to the cmr-ON state. Interestingly, Clade 5 strains with a bias towards the cmr-ON state shifted to a largely cmr-OFF state during murine infection, suggesting that the cmr-OFF state is under positive selection during infection. Collectively, our data reveal that Clade 5 strains have distinct growth properties, which may allow them to inhabit diverse ecological niches.

Unique growth and morphology properties of Clade 5 Clostridioides difficile strains revealed by single-cell time-lapse microscopy PLOSPathogens

Marie Curie fellowship, post-doc hosting oppotunity in my lab. MSCA Post-doctoral Fellowship at IBPC Paris on RNA modifications in bacteria (FRANCE) 🦠💫 euraxess.ec.europa.eu/jobs/hosting...

3CdF 2025 Fourwaves - 3CdF 2025

Happy to announce 2nd #3CdF Cross-channel C. difficile Forum in Newcastle, June 4-5 for #Cdiff researchers from UK, France and Europe, w/ strong emphasis on ECRs! Thanks to @microbiologysociety.org support!
event.fourwaves.com/3cdf-2025/pa...
Registration & abstract submission still open! #MicroSky

If you're interesting in attending, registration and abstract submission are still open! Pls share!
Please note that accommodation at special rates ends tomorrow! #3CdF #Microsky #Cdiff

Role of Thioredoxin Reductase (TrxB) in Oxidative Stress Response of Francisella tularensis Live Vaccine Strain https://www.biorxiv.org/content/10.1101/2025.04.27.650861v1

Cooperation Between Genotoxic Bacteria Accelerates Tumorigenesis in a Mouse Model of Colon Carcinogenesis https://www.biorxiv.org/content/10.1101/2025.04.18.649375v1

Phage therapy for Klebsiella pneumoniae: Understanding bacteria–phage interactions for therapeutic innovations Klebsiella pneumoniae (KP) is a Gram-negative bacterium that commonly resides in the human gastrointestinal tract and can also act as an opportunistic pathogen and cause extra-intestinal infections. K...

Our review on recent advances in #PhageTherapy against Klebsiella pneumoniae is out!
We analyze KP-phage interactions from an eco-evo perspective, summarize many lab and clinical trials, and discuss novel approaches like genetic engineering & machine learning.
#microsky
doi.org/10.1371/jour...

Congrats Sol!

So happy to have published my PhD work! What a funky phage, it was a ride. Big thanks to @beatrizbeamud.bsky.social & @jmouradesousa.bsky.social for bringing their expertise into this story. And my mentors @jmghigolab.bsky.social & @dbikard.bsky.social 💪🏼

Serotonin modulation of metabolism and stress response in Pseudomonas fluorescens https://www.biorxiv.org/content/10.1101/2025.04.03.646968v1

Another piece in the puzzle of the oxidative stress defense of C. difficile! A really nice work by @alotoux.bsky.social and others

Defense arsenal of the strict anaerobe Clostridioides difficile against reactive oxygen species encountered during its infection cycle | mBio ROS plays a fundamental role in intestinal homeostasis, limiting the proliferation of pathogenic bacteria. Clostridioides difficile is an important enteropathogen that induces an intense immune respon...

Clostridioides difficile vs. Oxidative Stress again! Take a look at how this strict anaerobe faces ROS through its arsenal of detoxification enzymes. A key adaptation for its survival! 🔬✨

doi.org/10.1128/mbio...

PhD Summer School on Host-Microbe Symbioses 2025 Symbnet PhD Summer School on Host-Microbe Symbioses Gulbenkian Institute for Molecular Medicine (GIMM) & Católica Biomedical Research Centre (CBR) July 06...

Symbnet PhD Summer School on Host-Microbe Symbioses - Oeiras Portugal. Students from all over the world are eligible, we sponsor selected students. Please Repost!
gimm.idloom.events/phd-summer-s...

Halophilic archaea produce wax esters and use an alternative fatty acyl-CoA reductase for precursor synthesis Abstract. Wax esters are fatty acid-based neutral lipids thought to be restricted to bacteria and eukaryotes that play a key role in the functioning and ma

Yes Archaea too can get fat 😁
New paper from the lab (by bsky-less Guillaume Borrel)!
Check it out👇👇 #archaeasky #microsky @institutpasteur.bsky.social
academic.oup.com/ismej/advanc...

So excited to share this latest work by @kelseyhuus.bsky.social !!!
She shows that flagellin in the human gut affects whether or not people develop fever in response to vaccine, and the amount of flagellin reflects diet

Voici un starter pack pour suivre la recherche en France : instituts, laboratoires, universités et agences.

N'hésitez pas à proposer des comptes à ajouter !
go.bsky.app/JSXcYqn