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Kheya Sengupta

@kheya2025

Scientist at CNRS, France. Physics of Living Systems. This one is meant for science - will try to keep politics and whimsy out but no guarantees.

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29.01.2025
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Latest posts by Kheya Sengupta @kheya2025

Check out #17 to help unravel one of the central mysteries in immunology: how, starting from a single bond between a receptor and an antigen, T cells can activate the whole cell and eventually the whole organism?

07.01.2026 11:28 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Point of no returns: researchers are crossing a threshold in the fight for funding With so little money to go round, the costs of competing for grants can exceed what the grants are worth. When that happens, nobody wins.

Point of no return: academic #funding is at a tipping point. When the effort and money spent applying for grants equals or exceeds the funding awarded, the system stops serving science and starts draining it. Time to rethink how we fund #research.
πŸ§ͺ🌐🌍
www.nature.com/articles/d41...

06.01.2026 09:33 πŸ‘ 40 πŸ” 19 πŸ’¬ 1 πŸ“Œ 3

The CENTURI PhD Call 2026 is still ongoing. Applications are open until the end of the month, on January 28th!

Visit centuri-livingsystems.org/recruitment/ to apply.

#PHD #CENTURI

05.01.2026 08:34 πŸ‘ 16 πŸ” 18 πŸ’¬ 1 πŸ“Œ 1
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Israel's arms manufacturers benefit from EU funding for cutting edge civilian research Public data shows that Israeli arms companies have won grants for civilian projects despite a strict EU ban on funding research that can be used in warfare

"Unlike the EU, Israel does not maintain strict separation between civilian and military research, as its research ecosystem is structurally intertwined with its defence sector."

www.middleeasteye.net/news/israels...

06.01.2026 18:04 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Thrilled to share our recent work in
@emboreports.org that uncovered actin waves in lymphocytes, which rescue antigen receptor loss during immune responseπŸŽ‰πŸŽ‰. Super thankful to DBT-Wellcome India Alliance, anrf india, Infosys, and MOE-STARS
πŸ™πŸ™πŸ™

link.springer.com/article/10.1...

Thread below:

31.12.2025 05:11 πŸ‘ 4 πŸ” 2 πŸ’¬ 1 πŸ“Œ 0

Who wants a hallucinating fridge?

24.12.2025 00:33 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Very true.
Must donate time and money because it is under attack (mostly from history-rewriting far right for now).

24.12.2025 00:30 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Making Mathematics Fun and Relevant | Marathi About Speaker: Nagesh Mone Language: Marathi https://www.facebook.com/teacherpages/posts/meet-principal-of-new-english-school-pune-school-leader-nagesh-mone-27-years-a-t/1027952043894415/

India celebrates National #MathematicsDay (NMD) on 22nd December to honor the birth anniversary of legendary Indian mathematician Srinivasa Ramanujan. To mark this, the #iiserpune #ScienceActivityCentre has organised a talk (in Marathi)
youtube.com/live/_ET-xvN...

20.12.2025 05:59 πŸ‘ 2 πŸ” 1 πŸ’¬ 1 πŸ“Œ 0

poke a finger in and push one over... the Africa-born pretend-engineer racist first.

13.12.2025 10:06 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Morphodynamics of T-lymphocytes: Scanning to spreading Binding of the TΒ cell receptor complex to its ligand, the subsequent molecular rearrangement, and the concomitant cell-scale shape changes represent the very first steps of adaptive immune recognition...

Credit Pierre Dillard. Here is our review written years after Pierre went off to sell Mice to Men (and presumably also women. at Janvier Labs)
www.cell.com/biophysj/ful...

10.12.2025 18:54 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Some old unpublished images of LifeAct T cells spreading on various activating or non-activating surfaces.

10.12.2025 18:41 πŸ‘ 2 πŸ” 1 πŸ’¬ 1 πŸ“Œ 0

Is it really true that intermediate filaments are condensates?

10.12.2025 15:56 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

****PhD opportunity in Marseille : Physics of the immune system****

* How reaction-diffusion on a quasi-2D landscape determines the first steps of immune cell response*

*Membrane physics as the earliest amplifier of T Cell signal initiation:implications for health & disease*

Check out #6 and #17

04.12.2025 20:37 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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is there a direct crosstalk between actin and vimentin intermediate filaments? Our work shows that vimentin promotes actin assembly by stabilizing ATP-subunits at the barbed end.
Fantastic work done by @lilianpaty.bsky.social with @romet-jegou-lab.bsky.social

www.biorxiv.org/content/10.1...

24.11.2025 10:15 πŸ‘ 42 πŸ” 18 πŸ’¬ 0 πŸ“Œ 1

Today, on **November 27th, at 16:30 CET**,
Franziska LautenschlΓ€ger from the Universitat des Saarlandes, Germany, will give the next Immunobiophysics seminar:
"The cytoskeleton steering immune cell migration and circulating tumor cells"

27.11.2025 08:57 πŸ‘ 3 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
Screenshot of Essay from Martin Schwartz on 'Why would anyone want to be a scientist'. An anniversary article from The Company of Biologists published in Journal of Cell Science.

The first few lines are: It is difficult to fathom why anyone intelligent enough to be a scientist would actually choose to be one. Doing good science requires the utmost exertion of body, mind and spirit, yet is consistently filled with failure and rejection. But, strange even to myself, I not only don't question the unfavorable risk-to-reward ratio but consider myself astonishingly lucky to be a scientist. There are three fundamental pleasures that have sustained me through 50 years of this madness.

Screenshot of Essay from Martin Schwartz on 'Why would anyone want to be a scientist'. An anniversary article from The Company of Biologists published in Journal of Cell Science. The first few lines are: It is difficult to fathom why anyone intelligent enough to be a scientist would actually choose to be one. Doing good science requires the utmost exertion of body, mind and spirit, yet is consistently filled with failure and rejection. But, strange even to myself, I not only don't question the unfavorable risk-to-reward ratio but consider myself astonishingly lucky to be a scientist. There are three fundamental pleasures that have sustained me through 50 years of this madness.

Why would anyone want to be a scientist?

Check out our new Essay from Martin Schwartz: journals.biologists.com/jcs/article/...

15.08.2025 13:19 πŸ‘ 81 πŸ” 46 πŸ’¬ 2 πŸ“Œ 8

Check out #6 and #17 ... seeking to unravel the central mystery of immune recognition/response with some help from physics.

24.11.2025 23:32 πŸ‘ 3 πŸ” 3 πŸ’¬ 0 πŸ“Œ 1

come and work with us in Marseille.

Lovely place, lovely people, lovely science.
πŸ„β€β™‚οΈβ˜€οΈπŸš΅β€β™€οΈ+πŸ‘©β€πŸ”¬πŸ˜ŽπŸ•Ί +πŸ”¬πŸ§«πŸ§ͺ

*How reaction-diffusion on a quasi-2D landscape determines the first steps of immune cell response*

26.11.2025 14:05 πŸ‘ 1 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0

Check out #6 and #17 ... seeking to unravel the central mystery of immune recognition/response with some help from physics.

24.11.2025 23:32 πŸ‘ 3 πŸ” 3 πŸ’¬ 0 πŸ“Œ 1
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Meet Our Speakers – IBIAM 2025
We are delighted to announce our keynote speaker for the India BioImaging Annual Meeting 2025 (IBIAM, 2025)

Chaitanya Athale
Professor, Indian Institute of Science Education and Research (IISER), Pune, India

Date: December 11–12, 2025
Venue: JSS AHER Mysuru, India

05.11.2025 09:58 πŸ‘ 3 πŸ” 1 πŸ’¬ 1 πŸ“Œ 0
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Spatio-temporal Patterns of T Cell Traction Forces Depend on Stimulation and Cell Subtype T cells exert forces to sense mechano-chemical cues from their target cells. These forces are feeble and are influenced by environmental factors; as a result, they have often been measured under non-p...

A True Limerick on T cell Traction

T cells push and force-dipoles form.
But that is not exactly the norm.
They may pull and let go,
or simply tiptoe.
Or they may pull, signal & transform.

If you want to know more, check out BIORXIV/2022/480084
www.biorxiv.org/content/10.1...

04.11.2025 21:36 πŸ‘ 3 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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Plastic recycling is counter-productive

#CNRSNewsπŸ“° Plastic pollution worldwide is harmful to the environment and health, causing cancer and other life-threatening diseases. Yet recycling has its limits, and even boosts consumption. Scientists insist the only viable option is to stop plastic production

27.10.2025 15:11 πŸ‘ 20 πŸ” 11 πŸ’¬ 1 πŸ“Œ 1
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✨ πŸ‘©β€πŸ”¬ Toutes nos fΓ©licitations Γ  @sophiecarenco.bsky.social du CINAM et Dorothea vom Bruch du CPPM qui sont laurΓ©ates des prix 2025 de @academiesciences.bsky.social !
@univ-amu.fr @cnrs.fr @cnrs-in2p3.bsky.social

www.provence-corse.cnrs.fr/fr/cnrsinfo/...

28.10.2025 18:13 πŸ‘ 11 πŸ” 4 πŸ’¬ 0 πŸ“Œ 0

We are back!
*Immunobiophysics online seminars*
This Thursday with Mike Dustin.

28.10.2025 22:55 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Thrilled to announce Prof. Michael Dustin, University of Oxford, UK for the first presentation of the academic year:

"Hacking the immunological synapse with supported lipid bilayers and T cell engagers"

->October 30th at 16:30 CET (3:30 PM UTC)<-

28.10.2025 22:15 πŸ‘ 2 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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Amazing life story!

08.10.2025 20:48 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Jochen, you left before we could play our promised Table-Tennis rematch at Les Houches. A great physicist and a wonderful human. You will be sorely missed by our community.
So sorry that you had to go so soon.

05.10.2025 09:22 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Fascinating story!

01.10.2025 17:14 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

hmmm.... may be. but I would turn that around to Physicists and Mathematicians are wizards and Chemists and Biologists are witches. That makes some of us both. And yes about warlocks - very war-like too.

30.09.2025 15:10 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Tracing Erich Sackmann’s journey from liquid crystals to biological membranes Biological membranes and liquid crystals are closely related because they exhibit similar types of molecular ordering and symmetry. This deep connection led many researchers in the 1960s and 1970s to ...

A homage to a beloved mentor...
"Tracing Erich Sackmann’s journey from liquid crystals to biological membranes" is now out in the special issue of BioPhysJ dedicated to Erich Sackmann.
Thank you Laurent, Laurent and Jacques (and Celine).

www.cell.com/biophysj/abs...

29.09.2025 16:26 πŸ‘ 2 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0