Great to work with you on this story. Excited for what’s coming next!
10.03.2026 00:14
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Great to work with you on this story. Excited for what’s coming next!
Our work on bacterial Schlafens in phage defense is out today @natmicrobiol.nature.com!
Check out the final version here:
rdcu.be/e7Bmz
We are looking for postdocs and students to expand our team! Official postings are coming soon.
Please reach out if you're interested!
#phage #phagesky #microsky
Exciting times ahead!
Today marks the first day of the Loeff Lab at Leiden University Medical Center in the Netherlands 🇳🇱. I’m thrilled to begin this new adventure and continue exploring microbial defense mechanisms and their applications through an integrative structural biology approach.
A schematic of a bacterial cell being infected by a phage, with the Cas operon and CRISPR locus detailed. The Cas1-2/3 integrase adopts distinct conformations during the capture, delivery, and integration of a short fragment of the phage DNA.
New preprint from the Wiedenheft lab!
We used #cryoEM to show how a type I-F #CRISPR integrase captures, delivers, and integrates foreign DNA.
www.biorxiv.org/content/10.1...
First preprint from the Nemudryi Lab! 🍾
In this work, we link antiviral immunity in bacteria and humans by showing that homologs of human Schlafen nucleases protect bacteria from phages.
www.biorxiv.org/content/10.1...
@anemudraia.bsky.social and I are grateful to our very first team members, Veronica, Yimo, and Riley, who bravely joined the lab early on and worked hard on this project!
And big thanks to our collaborators, @lloeff.bsky.social and @kirillemedvedev.bsky.social. Excited for what’s next!
David Liu @harvard.edu beautifully articulates the criticality of basic science funding for developing revolutionary therapeutics like life-saving base editors 👏
youtu.be/8YhJM6zxYDw?...
Congrats, Jerrin!