Sharad Kumar

Increased Urinary Extracellular Vesicles and Reduced Expression of NEDD4L in Patients With Type 2 Diabetes and Diabetic Nephropathy Introduction Diabetic nephropathy (DN) is a leading cause of chronic kidney disease. Current diagnosis requires the persistent presence of albuminuria and/or reduction in estimated glomerular filtra...

onlinelibrary.wiley.com/doi/full/10....

Congratulations Ben- beautiful work 👏🏻

Hidden cancer risk behind fatty liver disease targets Scientists have discovered that blocking a key cellular enzyme thought to protect against fatty liver disease may instead increase the risk of chronic liver damage and cancer as we age.

Hidden cancer risk behind fatty liver disease targets | EurekAlert! www.eurekalert.org/news-release...

Caspase-2 deficiency drives pathogenic liver polyploidy and increases age-associated hepatocellular carcinoma in mice Caspase-2 inactivation promotes pathogenic hepatocyte polyploidy and age-related liver cancer.

Caspase-2 deficiency drives pathogenic liver polyploidy and increases age-associated hepatocellular carcinoma in mice | Science Advances www.science.org/doi/full/10....

Caspase-2 deficiency drives pathogenic liver polyploidy and increases age-associated hepatocellular carcinoma in mice Caspase-2 inactivation promotes pathogenic hepatocyte polyploidy and age-related liver cancer.

Great to see this work, led by Loretta Dorstyn, with contributions from many colleagues and funded by NHMRC now out. Our first publication of 2026 and from the new Adelaide University.
www.science.org/doi/10.1126/...

Caspase-2 deficiency drives pathogenic liver polyploidy and increases age-associated hepatocellular carcinoma in mice Caspase-2 inactivation promotes pathogenic hepatocyte polyploidy and age-related liver cancer.

Great to see this work, led by Loretta Dorstyn, with contributions from many colleagues and funded by NHMRC now out. Our first publication of 2026 and from the new Adelaide University.
www.science.org/doi/10.1126/...

Caspase-2 inactivation promotes pathogenic hepatocyte polyploidy and age-related liver cancer
www.science.org/doi/10.1126/...
@molregulation.bsky.social

Trump administration to add $100,000 fee for H-1B visas The Trump administration is targeting a visa widely used by tech companies and other employers to hire foreign workers.

Of all the stupid things that this regime has done, this is right up near the top. Postdoctoral researchers come to the US on H-1B visas. This will further destroy the US science enterprise. Stupid stupid stupid.

That said, if the application is generated using an AI, everyone will get a perfect score☺️

AI could eliminate dodgy and biased human assessments, one day!

Locals in Adelaide are now in full bloom 😊

LYVAC/PDZD8 is a lysosomal vacuolator Lysosomal vacuolation is commonly found in many pathophysiological conditions, but its molecular mechanisms and functions remain largely unknown. Here, we show that the endoplasmic reticulum (ER)–anch...

Very cool study:
LYVAC/PDZD8 is a lysosomal vacuolator | Science www.science.org/doi/10.1126/...

Phospholipid scramblase 1 (PLSCR1) is a novel substrate of NEDD4-2 (NEDD4L) mediated ubiquitination - Cell Death Discovery Cell Death Discovery - Phospholipid scramblase 1 (PLSCR1) is a novel substrate of NEDD4-2 (NEDD4L) mediated ubiquitination

www.nature.com/articles/s41...
New publication from our lab.

Shades of Spring in Adelaide: frost and Sakura 😊

Nedd4-2 ablation in kidney improves glycaemic control in diabetic mice - Cell Death & Disease Cell Death & Disease - Nedd4-2 ablation in kidney improves glycaemic control in diabetic mice

🧬 New paper alert!
@molregulation.bsky.social’s team reveals a paradox: Nedd4-2 deficiency triggers kidney injury but protects against high blood glucose in diabetes. Fascinating twist! 🔄

Organ clocks for post-menopausal women taking estrogen or not taking estrogen

New organ clock data support the anti-aging benefits of estrogen for postmenopausal women. Reviewed here in context with previous and other recent reports.
erictopol.substack.com/p/new-anti-a...

Climate risk for younger generations is set to soar An analysis shows that large fractions of future generations will be exposed to extreme climate events that would occur only once every 10,000 years in the absence of global warming.

An analysis shows that large fractions of future generations will be exposed to extreme climate events that would occur only once every 10,000 years in the absence of global warming

https://go.nature.com/43lhNbO

Tiger turnaround as populations grow in India Nature - Tiger numbers in India are starting to rebound after decades of being perilously low. This recovery offers lessons for conserving other rare animals.

Tiger numbers in India are starting to rebound after decades of being perilously low.

This recovery offers lessons for conserving other rare animals

https://go.nature.com/3EpQfIA

Spatial multi-omics reveals cell-type-specific nuclear compartments @nature.com
www.nature.com/articles/s41...

Timing and trajectory of BCR::ABL1-driven chronic myeloid leukaemia - Nature Explosive growth is attributed to the BCR::ABL1 gene 3–14 years before diagnosis of chronic myeloid leukaemia, highlighting the oncogenic potency of gene fusion and the slow and sequential trajectories of most other cancers.

Nature research paper: Timing and trajectory of BCR::ABL1-driven chronic myeloid leukaemia

https://go.nature.com/4j2WTDZ

A mental-health crisis plagues PhDs — these evidence-led initiatives offer help Communities of researchers worldwide are taking on the toxic research cultures that drive poor psychological health among academics.

Studies of researchers globally suggest there is a mental-health crisis in academia

https://go.nature.com/3RNAbmZ

What makes us human? Milestone ape genomes promise clues DNA sequences for the chimpanzee, orangutans and more will help scientists to determine what sets humans apart from other apes.

“I’ve never thought that this would be accomplished in my lifetime”

Researchers have successfully sequenced the complete genomes of six ape species

https://go.nature.com/4j9jE9k

Biggest brain map ever details huge number of neurons and their activity 3D reconstruction is the first to overlay neuronal activity on a large-scale map of brain cells.

Researchers have created the largest and most detailed wiring diagram of a mammalian brain to date, by mapping cells in a cubic millimetre of a mouse’s brain tissue

https://go.nature.com/4cu68dN

Cancer vulnerabilities exposed by finding interactions among DNA repair factors @nature.com @jcornlab.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/d41...

Of >105,000 participants with 30-year follow-up, only 9.3% achieved healthy aging (age 70, w/o any chronic diseases). Their diet was significantly associated with this outcome. @naturemedicine.bsky.social

AUKUS can fund ARC for 360 years 😬

Overseas universities see opportunity in U.S. ‘brain drain’ But many U.S.-based scientists seeking to leave may struggle to find positions in countries grappling with funding issues of their own

Overseas universities see opportunity in U.S. ‘brain drain’ | Science | AAAS www.science.org/content/arti...

These frustrated scientists want to leave the United States – do you? Take Nature’s poll Nature - In the wake of the Trump administration’s funding freezes and job cuts, some researchers are planning their next move.

Some scientists in the United States have told Nature that they are considering leaving the country in the wake of widespread disruption to research brought in by the Trump administration

Are you thinking about leaving?

https://go.nature.com/4bMGd0J

Senolytic treatment for low back pain Senolytics drugs can reduce back pain by removing senescent cells from the intervertebral discs and spinal cord.

The potential of senolytics for treating low back pain, removing senescent cells that are implicated, as seen ex vivo and in the mouse model.
www.science.org/doi/10.1126/...

Great work Sylvia and the team-congratulations!!