Todd Gleeson, MD, MPH

Superb illustration highlighting the effectiveness and safety of measles vaccines

ourworldindata.org/measles-vacc...

#IDSky #PedIDSky #PaedIDSky #Vaccine #Measles #MMR

Economic Evaluation of Enhanced Cleaning of Shared Medical Equipment This economic evaluation examines whether improved environmental cleaning and disinfection of shared medical equipment would be cost-effective compared with usual care.

Improving the cleaning & disinfection of shared equipment reduces hospital-acquired infections and saves hospitals money. Paper out today in JAMA Network Open. #@escmid.bsky.social #ESCMIDGlobal #IDSky

CE paper: jamanetwork.com/journals/jam...

Summary: The Conversation tinyurl.com/23mn8y7a

#MedSky
Invasive cardiopulm exercise testing (iCPET) at Brigham & Women’s finds people w/ #MECFS & #longCovid have symptomatic ⬇️ aerobic capacity at peak exercise due to preload insufficiency & impaired systemic O2 extraction, latter c/w peripheral L➡️R shunt &/or limb skel muscle dysfunction. /1

Persistent alterations in gray matter in COVID-19 patients... : Neural Regeneration Research JOURNAL/nrgr/04.03/01300535-202510000-00030/figure1/v/2024-11-26T163120Z/r/image-tiff

#Medsky 🧪 #IDSky #immunosky #publichealth #Neurocovid with prolonged sleep disturbances may have Persistent alterations in gray matter
journals.lww.com/nrronline/fu...

www.tandfonline.com/doi/pdf/10.2...

academic.oup.com/braincomms/a... @braincomms.bsky.social

Association of number of positive blood cultures and probability of IE for MSSA, MRSA, E. feacalis and Streptococcus spp.
jamanetwork.com/journals/jam...

#IDSky

Evidence for selection of doxycycline resistance in Staphylococcus aureus in DoxyPrEP study In their doxycycline preexposure prophylaxis (doxyPrEP) randomized controlled study, Grennan et al. conclude that the risk of doxyPrEP selecting for antimicrobial resistance is low.

Evidence for selection of doxycycline resistance in Staphylococcus aureus in DoxyPrEP study

✅ Just Accepted
#IDSky

Top virologists urge world leaders to act on rising avian flu threat Global Virus Network scientists highlight the need for robust surveillance, enhanced biosecurity, and readiness for potential human-to-human viral transmission.

Top virologists from over 40 countries urge global leaders to address the growing threat of bird flu by boosting surveillance, enhancing biosecurity, and preparing for poss human-to-human transmission. #BlueSky #MedSky #IDSky #SciSky #EMSKy #NurseSky

www.cidrap.umn.edu/avian-influe...

UPDATE: RECOVER Long COVID pathobiology grants restored - The Sick Times Long COVID research grants from the National Institutes of Health’s RECOVER program will be restored following news stories about their abrupt cancellations and advocacy to restore the funding, accord...

🚨 BREAKING: Long COVID research grants rescinded earlier this week have been restored, according to researchers & patient reps. Advocates organized quickly yesterday in response to the news, helping reverse the decision.

Exclusive in @thesicktimes.bsky.social

thesicktimes.org/2025/03/28/u...

Growing measles outbreak in Texas pushes U.S. cases above 520 The number of recorded cases in less than three months in 2025 is higher than for any year in the last decade, except for one. Texas alone has 400 confirmed cases.

Measles cases in the U.S. this year now exceed 500, according to NBC News’ tally of state health department data.

It's only the end of March but already 2025 has logged more #measles cases than all but 2 other years since the US achieved measles elimination status in 2000.
#CDC reported there'd been 483 confirmed cases in 19 states as of 3/27. Likely out of date, with TX reporting Friday its count has hit 400

FDA Grants Marketing Authorization of First Home Test for Chlamydia, Gonorrhea and Trichomoniasis The FDA granted marketing authorization of the first at home diagnostic test for chlamydia, gonorrhea and trichomoniasis.

#IDSky #MedSky
FDA has just approved the first over the counter diagnostic test for chlamydia, gonorrhea, & trichomoniasis for home use by females with or without symptoms. Gives results in about 30 mins.

www.fda.gov/news-events/....

For decades, a doctor refused to charge patients who couldn't pay. When he couldn't pay, his patients came to his aid. When Dr. Michael Zollicoffer was diagnosed with two types of cancer, his patients started a crowdfunding campaign that raised more than $100,000.

Timeline cleanse. I wish this kind of #generosity were not necesssary. Healthcare is a human right. Still it is beautiful to see this. The community pays back a #Baltimore legend. ❤️‍🩹

#MedSky #OncSky #kcsm #crcsm #kindness #BlackMenInMedicine

www.cbsnews.com/news/beloved...

#IDSky #MedSky #GynSky
Adding treatment of the male partner (Metronidazole 400 mg po BID + topical 2% clinda to penile skin BID x 7 days) of females with bacterial vaginosis (BV) decreases recurrent BV within 12 weeks by 63% compared with treating females alone.

www.nejm.org/doi/full/10....

What is the Future of Treatments for COVID-19? In this raging flu season, where people with influenza-related illness outnumber those with COVID-19 for the first time since the pandemic hit in 2020, we might be fooled into thinking that we no long...

Remember #Covid? We STILL need better treatments.

@cidjournal.bsky.social just published an important clinical trial of ensitrelvir vs placebo.

Comments here, plus links to an excellent accompanying editorial by Drs Zim & @aussiedocwolfe.bsky.social.
#IDSky blogs.jwatch.org/hiv-id-obser...

Funding cuts to tuberculosis programmes endanger millions of lives In the past two decades, tuberculosis (TB) prevention, testing, and treatment services have saved more than 79 million lives—averting approximately 3.65 million deaths last year alone from the world’s...

"Early reports to WHO from the 30 highest TB-burden countries confirm that funding withdrawals are already dismantling essential services, threatening the global fight against TB."
@who.int calling attention to impact of US funding cuts on #tuberculosis #IDsky 🧪
www.who.int/news/item/05...

Second death reported in measles outbreak as cases climb over 200 The death of a New Mexico adult comes after a 6-year-old died of the disease in Texas last week.

#IDSky
About 1 in 5 people who get measles end up hospitalized. Get vaccinated. This is preventable.

www.washingtonpost.com/health/2025/...

24 measles cases in 2 weeks in this small Texas town. That's a 140% increase. 9 cases required hospitalization- that is almost 40%.
ALL cases occurred in unvaccinated children and adults (n=2).
Please vaccinate your children. Measles is preventable.
www-kcbd-com.cdn.ampproject.org/c/s/www.kcbd...

CDC says person diagnosed with new mpox variant in New York is in isolation The U.S Centers for Disease Control and Prevention said on Wednesday that a person diagnosed with clade1b mpox in New York was currently in isolation and that it was trying to identify people who might have come in contact with the patient.

New York health department has confirmed a case of clade I mpox in a returning traveller who visited E.Africa. This is the 4th case of clade I mpox in the US. #Mpox remains public health emergency of international concern with multiple outbreaks across Africa.
www.reuters.com/business/hea...

New bird flu variant found in Nevada dairy cows has experts sounding alarms: 'We have never been closer to a pandemic from this virus' Dairy herds in Nevada have been infected by a version of the H5N1 bird flu not previously seen in cows, putting virologists on high alert.

New bird flu variant found in Nevada dairy cows has experts sounding alarms: ‘We have never been closer to a pandemic from this virus' Important👇

fortune.com/well/2025/02... #H5N1 #BirdFlu
#BlueSky  #MedSky 🧪 #IDSky
#scisky #medtwitter #EMSky #EMedSky #nursesky #MedEd #fmsky #pedsky

History taking for the win - and when was the last time you changed/filled your window washer fluid? #IDSky

In-depth Analysis of the HIV Reservoir Confirms Effectiveness and Safety of Dolutegravir/Lamivudine in a Phase 4 Randomized Controlled Switch Trial (RUMBA) Reducing the number of active compounds for lifelong human immunodeficiency virus (HIV) treatment is of interest, especially to reduce potential long-term side effects.

In-depth Analysis of the HIV Reservoir Confirms Effectiveness and Safety of Dolutegravir/Lamivudine in a Phase 4 Randomized Controlled Switch Trial (RUMBA)

#IDSky

The New England Journal of Medicine Oral Regimens for Rifampin-Resistant Tuberculosis A PLAIN LANGUAGE SUMMARY Visual representation of a patient with rifampin-resistant tuberculosis. Read the full Plain Language Summary at NEJM.org.

In the endTB trial, researchers assessed the efficacy and safety of five 9-month, all-oral treatment regimens, as compared with the evolving standard of care, in participants with rifampin-resistant, fluoroquinolone-susceptible tuberculosis. nej.md/3WFFJTv

#MedSky #IDSky

Nasal COVID-19 vaccine based on WashU technology to enter U.S. clinical trials | WashU Medicine Trial will assess safety, efficacy of next-generation vaccine given via nasal spray, inhalation

Nasal COVID-19 vaccine based on WashU technology to enter U.S. clinical trials buff.ly/4hPuTSX

A version of the vaccine has been available in India since 2022 through a licensing agreement between WashU and the Indian biotechnology company Bharat Biotech.

#medsky #idsky 😷🧪

Flu season in the US is the most intense it's been in at least 15 years The U.S. winter virus season is in full force, and by one measure is the most intense in about 15 years.

#MedSky
It’s not too late to get a #FluShot if you didn’t get one in the fall, & Tamiflu reduces risk of hospitalization & death if you have the #Flu. It is also used as post exposure prophylaxis if you’ve been in close contact w/ someone who has flu. Sick? Call your dr!

apnews.com/article/us-f...

A forest plot of the primary efficacy analysis at week 73.

In the endTB phase 3 trial, three 9-month, all-oral regimens were found to be noninferior to standard treatment (typically 18 to 24 months) for rifampin-resistant tuberculosis. Read the full trial results: nej.md/3WFFJTv

#MedSky #IDSky

Your vaccination also protects the lives of babies under 1 who cannot be fully immunized. 10% of adults in NZ’s outbreak vs 2/3 of babies have had to be hospitalized.

Pertussis can make small children stop breathing and even a “mild” case in an adult can mean months of coughing so severe ribs break

Important article for #AMSSky, #TxID, #UTISky, and #IDSky in @cidjournal.bsky.social:

In neutropenic & non-neutropenic cancer patients w/ & w/o catheters, the absence of nitrite/leukocyte esterase or WBC<10 had high NPV for clinically significant bacteriuria

academic.oup.com/cid/advance-...

Consistent use of a face mask or respirator in indoor public settings was associated with lower odds of a positive SARS-CoV-2 test result (adjusted odds ratio = 0.44). Use of respirators with higher filtration capacity was associated with the most protection, compared with no mask use.

Trust science.

Don't be hesitant to wear a mask in indoor crowded settings.

#medsky #idsky

Maternal COVID-19 Infection Leads to Respiratory Distress Syndrome in Newborns The risk of developing RDS was significantly increased among newborns born to mothers with confirmed COVID-19 infection during pregnancy.

a meta analysis of 22 studies found that "Maternal #COVID infection during pregnancy is significantly associated with increased risk for respiratory distress syndrome (RDS) in newborns" - 11 % after maternal COVID.

#MedSky + #PedSky + #IDSky.

www.infectiousdiseaseadvisor.com/news/materna...

Visual abstract summarizing the operating characteristics of Mucorales PCR on different samples. Sensitivity (%) / Specificity (%) Tissue 89%/87% FFPE 71%/99% BALF 97%/96% Blood 81%/96%

The Diagnosis of Mucormycosis by PCR: A Systematic Review & Meta-Analysis

Lottie Brown et al for @ishamycology.bsky.social Fungal PCR Initiative

Sn/Sp of Mucorales PCR on different samples:

Tissue 89%/87%
FFPE 71%/99%
BALF 97%/96%
Blood 81%/96%

papers.ssrn.com/sol3/papers.... #MedMycoSky #IDSky