"GRNs, which should provide mechanistic explanations, are increasingly reduced to statistical correlations β βhairballsβ that fail to capture molecular causation"
By Maizels and @jamesbriscoe.bsky.social
www.nature.com/articles/s41...
Please check out our new preprint! Using single cell analysis paired with HCR to visualize transcript localization we have identified cell and tissue-specific expression of various genes encoding tubulins, kifs, and dyneins during neural crest development!
Call for Papers! Submit to the Splicing in Development and Disease special issue
Deadline extended: Submit your research on splicing in development and disease to the Differentiation special issue led by Guest Editors Natoya Peart and Karine Choquet by June 30, 2026. Learn more: https://www.sciencedirect.com/special-issue/322731/splicing-in-development-and-disease
π¬π¦In this Imaging spotlight, Kevin Dean @kevin-dean.bsky.social and team tell us about their motivation for designing Altair-LSFM, describe its key features, how to setup and use the system and their planned developments.
focalplane.biologists.com/2026/03/09/i...
Condensates are powerful ways to break symmetry and cells do remarkable things with them. Here we show that in a multinucleate fungus, a condensate regulates translation of a cyclin and a formin in distinct locations.
www.nature.com/articles/s41...
First 24 hours of embryonic development in 9 different animal species: (From left to right) Zebrafish, Sea urchin, Black widow spider, Tardigrade, Sea squirt, Comb jelly, Parchment tube worm, Roundworm, Slipper snail. Credit to @tessamontague.bsky.social & Zuzka VavruΕ‘ovΓ‘. #ZebrafishZunday #devbio π§ͺ
Colorful comparison of different zygote sizes from the minuscule C. elegans (50 micrometers) to the massive chick zygote (30k micrometers). Credit to Prof. Richard Behringer.
To give people a sense of the scale of these videos, check out this comparison of zygote sizes created by @rrbehringer.bsky.social π§ͺ #devbio
Cells use proteins like morphogens to talk to each other in order to build and maintain 3D tissue structures. But how do these morphogens reach distant cells when they are all packed together? We think long #cytonemes play a big role in shaping how cells talk to one another for growth.
#Dros26 Day 2
What antibodies do you wish we had? Comment below your antibody wishlist!
πΈ Drosophila egg chamber labeled with DSHB anti-hts in yellow
𧫠dshb.biology.uiowa.edu/hts-RC
Confocal micrograph of a mouse embryonic fibroblast with membrane labeled in blue, nuclei in yellow and cellular cytoplasm in red.
Happy #FluorescenceFriday! Here is a mouse fibroblast with multiple thin membrane extensions reaching out toward its neighbors. The long (>10 um) extensions are a type of signaling filopodia called #cytonemes that transport signals like SHH, WNT, Notch, and GFs! π¬ by Senior Scientist Hong Lin. π§ͺ π©βπ¬
Two complementary articles from the lab of Anming Meng and Katie McDole discussing the history and biology of organizer in π, πΈ, and π. Even after more than 100 years since its discovery, major questions remain, especially for mammals.
doi.org/10.1016/j.cd...
doi.org/10.1016/j.cd...
For #WomensHistoryMonth we spotlight Prof. Shaheen Sikandar. Her research shows how early pregnancy may protect against breast cancer by blocking age-related cell changes. A new @americancancersoc.bsky.social grant will allow her to shift focus from cure to prevention.
news.ucsc.edu/2026/01/preg...
Society for Developmental Biology Ethel Browne Harvey Postdoctoral Seminar Series Friday, March 13, 2026, 3:00pm - 4:00 pm Eastern Time Martha EchevarrΓa-Andino (University of Wisconsin-Madison) Hoxa11/Hoxd11 transcription factors regulate extracellular matrix genes during osteochondral differentiation M. Fernanda Palominos (University of California, Berkeley) Novel craniofacial genes linked to extreme jaw evolution in pupfishes revealed by tissue-specific transcriptomics and speciation genomics
The next the Ethel Browne Harvey Postdoc Seminar will be held Friday, February 13 at 3 pm Eastern Time with Martha EchevarrΓa-Andino @uwmadison.bsky.social and M. Fernanda Palominos @ucberkeleyofficial.bsky.social. Register today and join us. bit.ly/47QVIEK #SDBPostdocSeminar
No excuses to not apply now!
I was curious to try this M-index and wondered if it would reflect my commitment to mentorship. Based on my putting in lots of ppl who I know mentor a ton or not so much, it was cool to see this is actually semi reflective of reality.
Registration for our Spring Meeting on Neural Stem Cells and Cortex Development is open! Come join @steinaerts.bsky.social , @borrell-lab.bsky.social, @silvianeuro.bsky.social, Simon Hippenmeyer, @idoiaeu.bsky.social and Jin-Wu Tsai in ChΓ’teau Colonster on June 5th! www.bscdb.be/spring-meeting
VEGF signaling is required for blastema growth and the effect of VEGF inhibition is reversible. (A) schematic of experimental design; (B) representative DMSO-treated limb at 11 dpa (scale bar 100 ΞΌm; arrowhead indicates blastema; dashed line indicates amputation plane); (C) representative AV951-treated limb at 11 dpa (scale bar 100 ΞΌm; arrowhead indicates blastema; dashed line indicates amputation plane); (D) AV951-treated blastemas are significantly smaller at 11dpa; (E) representative DMSO-treated limb at 22 dpa (scale bar 100 ΞΌm); (F) representative AV951-treated limb at 22 dpa (scale bar 100 ΞΌm; arrowhead indicates blastema); (G) AV951-treated limbs show no regeneration at 22 dpa; (H) skeletal prep of representative DMSO-treated limb at 22 dpa (scale bar 250 ΞΌm); (I) skeletal prep of representative AV95-treated limb at 22 dpa (scale bar 250 ΞΌm); (J) AV951-treated blastemas display blocked regeneration compared to controls; (K) AV951-treated blastemas can develop to palette stage upon treatment removal
#DBfeature
VEGF signalling promotes blastema growth and proliferation of both vascular and non-vascular cells during axolotl limb regeneration
By Aaron Savage et al.
tinyurl.com/3xs4nffs
βIn biology, breaking isnβt always a failure,β said the developmental biologist Rashmi Priya (right). βItβs often a necessary step in building something new.β
www.quantamagazine.org/break-it-to-...
A CRISPR-based mitochondrial gene therapy tool derived by engineering guide RNAs
We wrote a perspective "How to build the regulatory genome: a constructionist guide to the cis-regulatory code", out in Development yesterday. Title says it all. Find it here:
journals.biologists.com/dev/article/...
Really proud to see the new @royalsocietypublishing.org special issue now open: "Beyond Boundaries: Celebrating Global South and Indigenous Contributions to Molecular and Cellular Biology", led by Dr Jennifer Lavers @seabirdsentinel.bsky.social, Prof Sandhya Visweswariah, and Dr Temitope Fadipe.
There's still time to apply to the PREP program at the University of Oregon! Deadline is March 2nd, see below for details.
Engineered pluripotent stem cells form somatic and germ cells that mimic a functional testis @science.org
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Graphical abstract that depicts the flow of experiments, showing the relation between different steps/protocols
We've redesigned a practical course on cell biology. This will run for the 1st time with 100+ students, starting next week. I've made a graphical abstract to help students (and myself) understand where we are in the process....
#TeachingTheNextGeneration
Awesome paper and super useful resource of CRISPR-based screens to identify regulators of #LipidDroplet biology under different metabolic conditions: crisprlipid.org
The next stop on our βImaging withβ¦β series is with the team at Super-resolution Microscopy Platform of the National University of Rosario, Argentina, which opened in July 2025. Read more about the Platform and the team in our post ‡οΈ: focalplane.biologists.com/2026/02/24/i...
β οΈ 1 week left for Pasteur Course "Advanced Bioimage Analysis With AI"! π©βπ¬π»
Intensive course (June 1-5, Paris): theory + hands-on, AI focus in bioimaging.
π Institut Pasteur
π£οΈ English
β° Deadline: March 1
π¬ Beginner basics, batch scripts, interactive sessions
π Apply: https://bit.ly/4c8rFKZ
Figure 2 of the article: Early development is accompanied by the emergence of novel acidic vesicles and the acidification of the embryo yolk platelets. Confocal optical sections corresponding to live embryos stained with Lysosensor (LyS; red in merge, inverted greyscale in first and third rows) and Nile red (NR; cyan in merge, inverted greyscale in last row). Developmental stages are indicated in minutes post-fertilisation (PF). A dense array of acidic vesicles occupies the egg's cytoplasm in developing embryos, but not in unfertilised eggs. At high magnification, these vesicles (circles) can be seen mingling with the yolk platelets. After the third cleavage (160 min PF), the Lysosensor signal is also detected at variable levels in the yolk platelets (arrows). These observations have been replicated in three independent experiments.
A metabolic paradox: mTor promotes lysosome biogenesis in sea urchin embryos
This Research Highlight showcases work from Sonia Dufour, Julia Morales and colleagues (@cnrs.fr): journals.biologists.com/dev/article/...
We are #Hiring! Our lab is looking for a LabTech/Lab Manager! Take a look to our research here!
physics-of-life.tu-dresden.de/team/pol-gro...
Drop a line if you are interested to know more details!
#labtech #labtechnician #biology #labtechnicians #labmanager #labwork #Xenopus #zebrafish #devbiol
π Download JCB's CELLULAR DIVERSITY poster! π© Sign up to receive our future special collections and download this beautiful artwork by Bianca Dunn to display at home or in the lab π info.rupress.org/jcb-collecti...
