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Teresa Mastracci

@teresamastracci

Associate Professor, Department of Biology @ Indiana University Indianapolis @iuibiology.bsky.social My lab focuses on diabetes & rare disease research. Science enthusiast. Proudly ๐Ÿ‡จ๐Ÿ‡ฆ

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18.10.2023
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Latest posts by Teresa Mastracci @teresamastracci

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Congratulations to Dr. Al Powers โ€” recognized with the Lacy Medal Award at the Midwest Islet Club meeting. So incredibly well deserved!! My scientific career was greatly impacted by you โ€” so very thankful for your time and mentorship, Al! #MIC2025

07.05.2025 21:29 ๐Ÿ‘ 4 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

Fantastic talks just now from experts @teresamastracci.bsky.social and @rlhull-meichle.bsky.social on crosstalk between the #islet and the surrounding #acinar and vascular tissue... are there novel pancreatic targets outside the islet to treat #T1D and #T2D? ๐Ÿ‡จ๐Ÿ‡ฆ Nat'l Grad Course @uoft.bsky.social

23.04.2025 19:15 ๐Ÿ‘ 4 ๐Ÿ” 2 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0
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Uphold US-Canada science A partnership can be demanding, and as with any couple, can have good days and bad. The United Statesโ€“Canada relationship is most definitely having a bad one. Itโ€™s difficult to fully comprehend all th...

Some thoughts on the new dynamic uncertain status and need for US-Canada Science diplomacy www.science.org/doi/10.1126/...

13.03.2025 19:59 ๐Ÿ‘ 9 ๐Ÿ” 7 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0
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Thank you.

We're strongest when we are united.

09.03.2025 23:26 ๐Ÿ‘ 12763 ๐Ÿ” 1687 ๐Ÿ’ฌ 650 ๐Ÿ“Œ 132
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As federal funding for research is uncertain, we need to diversify funding sources for our PhD students.

Here is a comprehensive list of >160 PhD fellowships and funding opportunities, mostly from private foundations and scientific societies.

Download it here: research.jhu.edu/rdt/funding-...

09.03.2025 21:15 ๐Ÿ‘ 129 ๐Ÿ” 97 ๐Ÿ’ฌ 2 ๐Ÿ“Œ 3
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Dissection of type 2 diabetes: a genetic perspective Diabetes is a leading cause of global mortality and disability, and its economic burden is substantial. This Review focuses on type 2 diabetes, which makes up 90โ€“95% of all diabetes cases. Type 2 diab...

Although obesity & a sedentary lifestyle are considerable contributors, research over the last 25 years has shown that type 2 #diabetes develops on a predisposing #genetic background, with family & twin studies indicating considerable heritability thelancet.com/journals/lan... #T2D
#MedSky #EndoSky

08.03.2025 13:38 ๐Ÿ‘ 4 ๐Ÿ” 1 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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We stand up for science!!

07.03.2025 19:13 ๐Ÿ‘ 30 ๐Ÿ” 3 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 2
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Indy killed it

@standupforscience.bsky.social

07.03.2025 19:01 ๐Ÿ‘ 340 ๐Ÿ” 45 ๐Ÿ’ฌ 9 ๐Ÿ“Œ 1
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Thank you #nPOD โ€” I remain speechless!! this meeting never disappoints and has become one that I look forward to every year to challenge thinking, expand my love of science (if thatโ€™s even possible!) and remind me of the warmth and generosity of friends and colleagues #nPOD2025 #sciencematters

05.03.2025 16:10 ๐Ÿ‘ 11 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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On #WorldObesityDay 2025 we present a special focus issue: "Decoding the complex systems of obesityโ€. We explore organ cooperation, metabolic health & environmental factors like diet in obesity. www.cell.com/cell-metabol...

04.03.2025 19:41 ๐Ÿ‘ 12 ๐Ÿ” 8 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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โœ‹๐Ÿ›‘ Scroll Checkpoint!

Feeling a little stressed? Give your mind a break with some โœจ Soothing Science โœจ featuring one of our stem cell lines.

๐Ÿ”Š Sound on for some tranquil audio

๐Ÿงช

03.03.2025 19:49 ๐Ÿ‘ 36 ๐Ÿ” 6 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0
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NIH announces some key grant-review meetings will restart in late March Trump policy blocking required notices has frozen reviews of thousands of grants

Some good news: The Federal Register has just posted NIH study sections, which are to meet in late March.

NIH announces some key grant-review meetings will restart in late March | Science | AAAS www.science.org/content/arti...

03.03.2025 19:33 ๐Ÿ‘ 111 ๐Ÿ” 47 ๐Ÿ’ฌ 6 ๐Ÿ“Œ 5
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Analysis of translational regulation using polysome profiling and puromycin incorporation Translation is the process of decoding an mRNA transcript to permit the synthesis of a protein. This process occurs in three steps: initiation, elongaโ€ฆ

New publication from the #Mastracci lab,which outlines 2 techniques that measure changes in mRNA #translation: polysome profiling and puromycin incorporation. We have detailed step-by-step protocols, including all the needed reagents to execute these techniques!
www.sciencedirect.com/science/arti...

19.02.2025 21:06 ๐Ÿ‘ 1 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

I have funding through at least 2031 for postdoctoral researchers with expertise in islet biology or cell-based therapies for, or modelling of, diabetes. Bring your expertise to a country that values it. ๐Ÿ‡จ๐Ÿ‡ฆ

Contact info on my website.

15.02.2025 16:40 ๐Ÿ‘ 665 ๐Ÿ” 206 ๐Ÿ’ฌ 12 ๐Ÿ“Œ 5
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When people see the maple leaf, they see possibility. They see freedom. They see a helping hand.

They see Canada, and the best of our values.

Happy 60th to our flag. ๐Ÿ‡จ๐Ÿ‡ฆ

15.02.2025 17:23 ๐Ÿ‘ 36780 ๐Ÿ” 4577 ๐Ÿ’ฌ 1063 ๐Ÿ“Œ 277
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Happy #ValentinesDay to all of our beloved developmental biologists from the ISDB team. Here is a heart made out of some migrating immune cells. It's only right that they are in pink. Do you spot another heart somewhere in the photo? ๐Ÿ˜Œ ๐Ÿ’—

14.02.2025 22:06 ๐Ÿ‘ 15 ๐Ÿ” 5 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 1
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Neuronal growth cones videoed through a differential interference contrast (DIC) microscope. #CellBiology #Science #Biology #microscopy

14.02.2025 18:35 ๐Ÿ‘ 15 ๐Ÿ” 7 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0
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Save NIH and NSF Research Funding โญ‘ 5 Calls On February 7, the Trump administration moved to cut billions of dollars in funding from the National Institutes of Health (NIH) and National Science โ€ฆ

A useful tool and a great thing to do...

5calls.org/issue/nih-ns...

10.02.2025 00:55 ๐Ÿ‘ 177 ๐Ÿ” 140 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 6
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How a Canadian scientist and a venomous lizard helped pave the way for Ozempic - National | Globalnews.ca In 1984, Dr. Daniel Drucker, an endocrinologist from the University of Toronto, discovered a hormone that helped pave the way for popular diabetes drugs such as Ozempic.

This is the most relevant article to NIH and research cuts Iโ€™ve seen.

Imagine if this was today , how many people would be saying โ€œWhy are we studying Gila Monsters and their impact on diabetes ? Thatโ€™s wasted money !โ€

globalnews.ca/news/9793403...

09.02.2025 21:58 ๐Ÿ‘ 48789 ๐Ÿ” 12460 ๐Ÿ’ฌ 1132 ๐Ÿ“Œ 436
Visual representation of "neural crest."

Visual representation of "neural crest."

A ๐—ป๐—ฒ๐˜‚๐—ฟ๐—ฎ๐—น ๐—ฐ๐—ฟ๐—ฒ๐˜€๐˜ is a group of ectodermal cells that are pinched off during neural tube closure. The neural crest migrates to various locations to contribute to diverse tissues, including melanocytes, craniofacial bones, and peripheral-nerve ganglia.

#MedSky #ScienceSky

08.02.2025 21:15 ๐Ÿ‘ 34 ๐Ÿ” 6 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0
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A case for broadening our view of mechanism in developmental biology ABSTRACT. Developmental biologists can perform studies that describe a phenomenon (descriptive work) and/or explain how the phenomenon works (mechanistic work). There is a prevalent perception that mo...

ICYMI: Commentary on "mechanism" in dev bio

Ozpolat et al argue for diverse approaches to mechanism - from molecular to systems level

journals.biologists.com/dev/article/...

05.02.2025 10:56 ๐Ÿ‘ 39 ๐Ÿ” 14 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 6
Half-moon in the daytime.

Half-moon in the daytime.

A blue sky with moon at #Bluesky. Astrophotography at daytime for a cleanse.

05.02.2025 12:51 ๐Ÿ‘ 11 ๐Ÿ” 3 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Birth defects are the #1 cause of death in the first year of life (๐Ÿงต). Birth defects kill more than twice as many children as cancer. Birth defects are diseases of developmental biology. Here are CDC statistics for 2021. 1/5

wisqars.cdc.gov/pdfs/leading...

04.02.2025 15:07 ๐Ÿ‘ 71 ๐Ÿ” 35 ๐Ÿ’ฌ 3 ๐Ÿ“Œ 5
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Here is the 2025 embryo alphabet from alligator to zebrafish. Developmental biology is stunning & leads to important discoveries for human medicine.
@socdevbio.bsky.social

01.02.2025 15:03 ๐Ÿ‘ 191 ๐Ÿ” 68 ๐Ÿ’ฌ 7 ๐Ÿ“Œ 5

Itโ€™s most definitely a delicious art form!!

25.01.2025 14:18 ๐Ÿ‘ 1 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Phase behavior of Cacio and Pepe sauce "Pasta alla Cacio e pepe" is a traditional Italian dish made with pasta, pecorino cheese, and pepper. Despite its simple ingredient list, achieving the perfect texture and creaminess of the sauce can ...

I will defend the importance of science until Iโ€™m blue in the face. As a society we need science to help us maintain health and resolve disease but we also need it to answer the simple everyday questions that can make our lives easier and happier. Case in pointโ€ฆ.
arxiv.org/abs/2501.00536

25.01.2025 11:34 ๐Ÿ‘ 3 ๐Ÿ” 1 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0
A stunning cosmic landscape featuring two prominent nebulae with radiant colorsโ€”reds, oranges, yellows, and blues, contrasting against the dark expanse of space. Twinkling stars fill the background, while wispy tendrils of gas and dust form intricate, organic patterns, adding depth and texture. This artwork falls under the genre of Astronomical and Space art.

A stunning cosmic landscape featuring two prominent nebulae with radiant colorsโ€”reds, oranges, yellows, and blues, contrasting against the dark expanse of space. Twinkling stars fill the background, while wispy tendrils of gas and dust form intricate, organic patterns, adding depth and texture. This artwork falls under the genre of Astronomical and Space art.

Presenting the Eighth Wonder of the World: The Rainbow Nebulae, a symbol of hope and inclusivity. A celestial masterpiece formed by interstellar gases and cosmic dust, spreading vibrant hues across the universe.

Author: @venusianchron.bsky.social

17.01.2025 13:50 ๐Ÿ‘ 3680 ๐Ÿ” 395 ๐Ÿ’ฌ 83 ๐Ÿ“Œ 14
Figure 5 Sox17mut5/mut5 GB epithelium displays metaplastic changes. (A) Hematoxylin and eosin (H&E) and AB-PAS staining of WT Sox17+/+ and Sox17mut5/mut5 GBs. Asterisks indicate intramural gland-like and crypt-like structures within Sox17mut5/mut5 GB epithelium. The structures contain gastric pyloric-type gland cells producing neutral mucins stained red (arrowhead) and intestinal goblet-like cells producing acidic mucins stained blue (arrows). (B) Immunofluorescent staining of Sox17+/+ and Sox17mut5/mut5 GBs with antibodies against epithelial cell marker EPCAM (green) and intestinal goblet cell marker TFF3 (red), with nuclei stained with TO-PRO3 (blue). Arrows indicate TFF3+ goblet-like cells within Sox17mut5/mut5 GB epithelium. Scale bars: 50โ€…ฮผm.

Figure 5 Sox17mut5/mut5 GB epithelium displays metaplastic changes. (A) Hematoxylin and eosin (H&E) and AB-PAS staining of WT Sox17+/+ and Sox17mut5/mut5 GBs. Asterisks indicate intramural gland-like and crypt-like structures within Sox17mut5/mut5 GB epithelium. The structures contain gastric pyloric-type gland cells producing neutral mucins stained red (arrowhead) and intestinal goblet-like cells producing acidic mucins stained blue (arrows). (B) Immunofluorescent staining of Sox17+/+ and Sox17mut5/mut5 GBs with antibodies against epithelial cell marker EPCAM (green) and intestinal goblet cell marker TFF3 (red), with nuclei stained with TO-PRO3 (blue). Arrows indicate TFF3+ goblet-like cells within Sox17mut5/mut5 GB epithelium. Scale bars: 50โ€…ฮผm.

Positive autoregulation of Sox17 is necessary for gallbladder and extrahepatic bile duct formation

Read this #OpenAccess Research Article by Linh Trinh, Ryan Finnel, Mark Magnuson and colleagues @vanderbilt.edu:
https://journals.biologists.com/dev/article/152/2/dev203033/365014/

18.01.2025 09:51 ๐Ÿ‘ 9 ๐Ÿ” 5 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
School of Science announces $1 million endowment in honor of former Dean: : News: About: School of Science: Indiana University IndianapolisIU Trident -

IU Indianapolis School of Science announced a $1 million endowment to establish the Simon J. Rhodes Legacy Scholarship. Dr. Rhodes is an unwavering supporter of trainees at all levels! Preference will be given to IPS students or those from Marion County,IN
science.indianapolis.iu.edu/about/news/a...

10.12.2024 19:54 ๐Ÿ‘ 2 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
2024 Nobel Prize lectures in physiology or medicine | Victor Ambros and Gary Ruvkun
2024 Nobel Prize lectures in physiology or medicine | Victor Ambros and Gary Ruvkun YouTube video by Nobel Prize

If you want to learn about how a tiny worm led to major insights in developmental biology and human disease check out the Nobel lectures from Victor Ambros and Gary Ruvkun. www.youtube.com/watch?v=VQ9N...

07.12.2024 21:54 ๐Ÿ‘ 34 ๐Ÿ” 13 ๐Ÿ’ฌ 2 ๐Ÿ“Œ 1