Signal Transduction and Targeted Therapy

Enhancing KLF15 expression in cardiomyocytes via a dCas9VPR-mediated transcriptional activation system prevents pathological remodeling and #Fibrosis, thereby establishing it as a critical regulator and #TherapeuticTarget in #HeartFailure.

#STTT #OpenAccess: doi.org/10.1038/s413...

Thromboxane A2 receptor activation in dendritic cells protects against #Sepsis by inhibiting S100a8/a9- mediated neutrophil infiltration and #SystemicInflammation, underscoring its potential as a #TherapeuticTarget.

#OpenAccess: doi.org/10.1038/s413...

GPR54 promotes progression & #MetabolicReprogramming in #NSCLC by enhancing dopa decarboxylase expression via the Gαq/11/PI3K/AKT/mTOR signaling pathway, underscoring its potential as both a #Biomarker & #TherapeuticTarget.

#OpenAccess: doi.org/10.1038/s413...

Scientists reveal PKCη as a driver of #TNBC #metastasis by suppressing Hippo signaling & activating YAP, while a uORF-encoded peptide degrades PKCη, highlighting a novel therapeutic vulnerability in aggressive #BreastCancer.

#OpenAccess in #STTT: doi.org/10.1038/s413...

This #STTT study reveals that cholesterol interacts with the spike protein's palmitoylated C-rich region to enhance #SARSCoV2 docking and fusion, highlighting the interaction as a potent #TherapeuticTarget.

#OpenAccess: doi.org/10.1038/s413...

📣 All accepted Proffered Paper, Mini Oral, Poster and ePoster abstracts for #ESMORareCancers26 are now online!
Dive into the latest research advancing sarcoma and rare cancers care.

🔗 https://ow.ly/GQI450Yp3SR

#esmomeetings

Researchers show dual-target CD19/CD22 #CARTTherapy plus ASCT achieves durable survival in #TP53-mutated r/r aggressive #BNHL, offering curative potential with consistent long-term safety and paving the way for next-gen #immunotherapies.

#OpenAccess in #STTT: doi.org/10.1038/s413...

Researchers introduce NApt8-3, a pan-coronavirus #DNAaptamer that targets the nucleocapsid protein to inhibit #NLRP3-mediated pulmonary #Inflammation, providing a programmable platform against emerging coronaviral infections.

#OpenAccess: doi.org/10.1038/s413...

Scientists map RNA modifications across #multiomics, revealing how genetic variants & PTMs converge to regulate cell fate & disease, with RMzyme offering a resource to explore RMPs as #biomarkers & therapeutic targets. #AcuteMyeloidLeukemia

#OpenAccess #STTT: doi.org/10.1038/s413...

This study identified VV261, an orally bioavailable nucleoside clinical prodrug, as a potent anti-#Chikungunya candidate that inhibits viral replication, significantly reducing viral loads and #Inflammation.

#OpenAccess: doi.org/10.1038/s413...

This study presents BiRDS, a DNA-based miR-22 #nanoplatform that penetrates the #retina via a minimally invasive route, suppresses pathological angiogenesis, remodels vessels, protects neurons, & preserves vision by inhibiting Wnt/β-catenin signaling.

#STTT: doi.org/10.1038/s413...

Enhance your skills in interventional cardiology through dedicated Coronary, Structural tracks and workshops at the #EAPCI26 Summit.

Register today to join us for this inaugural event: https://bit.ly/4q3o5oz

#EAPCI

Rodich on How Oncologists Can Discuss Integrative Medicine for Breast Cancer | OncLive Lillian Rodich, MSPAS, MPH, highlights ways that medical oncologists can counsel patients with breast cancer about integrative medicine modalities.

WATCH: Lillian Rodich, MSPAS, MPH, highlights ways that medical oncologists can counsel patients with breast cancer about integrative medicine modalities. @mskcancercenter.bsky.social #MBCC2026 #bcsm #oncology
www.onclive.com/view/rodich-...

The featured video from #GU26 is now available, the Keynote Lecture by Eliezer M. Van Allen, MD, “Reimagining Cancer Research and Care in the Age of Artificial Intelligence.”

Watch: https://bit.ly/47nKDtE

A randomized, double-blind phase 2b trial shows that #Bofanglutide dose-dependently reduces body weight & improves metabolism in overweight or #Obese Chinese adults, exhibiting a tolerable safety profile. @pku1898.bsky.social

#STTT #OpenAccess: doi.org/10.1038/s413...

This study reveals FUS as a key driver of fibrotic signaling in #IdiopathicPulmonaryFibrosis, with #antisense therapy (ION363) reducing profibrotic gene programs & improving patient-derived lung models, highlighting FUS as a promising therapeutic target.

#STTT: doi.org/10.1038/s413...

This multicenter, randomized, double-blind trial demonstrates that Tongxinluo capsule + standard #Statin therapy increases minimum fibrous cap thickness and reduces lipid arc in #AcuteCoronarySyndrome patients.

#STTT #OpenAccess: doi.org/10.1038/s413...

Researchers combine #TDDFT and docking to design theranostic probes for #AlzheimersDisease, showing aromatic delocalization and IAF tagging enhance optical response and selective binding to BACE1, #ADAM10, and neprilysin.

#OpenAccess in #STTT: doi.org/10.1038/s413...

This study employs immunogenic mapping to validate a #TrivalentVaccine strategy providing broad protection against #Sarbecoviruses, offering a scalable framework for pan-virus immunity and future #Pandemic preparedness.

#STTT #OpenAccess: doi.org/10.1038/s413...

Scientists show #CyclicdiGMP inhibits #breastcancer #metastasis by binding #PSMD3, disrupting PSMD3–TBK1 interaction, and suppressing NF‑κB signaling, positioning PSMD3 as a therapeutic target. #Antimetastatic @tulanemedicine.bsky.social

#OpenAccess #STTT: doi.org/10.1038/s413...

This #STTT study presents a high-resolution #Proteomic atlas of the human brain, revealing a three-module functional framework that governs neural interconnectivity, energy metabolism, and regional specialization.

#OpenAccess: doi.org/10.1038/s413...

The AACR Annual Meeting is the touchstone event for the cancer research community. #AACR25 convened 22,000 attendees from 85 countries to explore and expand the continuum of cancer science and medicine. Learn more in the AACR Annual Impact Report:
buff.ly/PSiw06M

Dr Pearson on the Role of AI for Drug Development and Discovery | OncLive Alexander T. Pearson, MD, PhD, discusses how AI can be used for oncologic drug discovery and development.

📹 Alexander T. Pearson, MD, PhD of @uchicagocancer.bsky.social explains how AI can be used for oncologic drug discovery and development. #oncology #AI
👉Watch the full video here: www.onclive.com/view/dr-pear...

Announcement for the 2026 ASBMB Annual Meeting session on lipids in cell communication and metabolism, featuring four expert speakers.

ASBMB 2026 symposium | March 9

"Lipids in cell-cell communication and metabolism in health and disease" will explore the multifaceted roles of lipids.
www.asbmb.org/annual-meeti...

🎤 Nada Abumrad, Michele Alves-Bezerra, Clair Crewe & Wei Ying
#ASBMB26 #LipidResearch #MakeItPossible

This study shows #SARSCoV2 upregulates #CD147, driving extended infection and immune imbalance; #Meplazumab blocks CD147–spike interaction, restores immune balance, and mitigates severe #COVID19, highlighting CD147 as a therapeutic target.

#OpenAccess #STTT: doi.org/10.1038/s413...

Findings from the randomized ATTENTION #ClinicalTrial demonstrate that #Aumolertinib plus #Apatinib significantly improves progression-free survival with manageable safety in treatment-naïve, #EGFR-mutant advanced #NSCLC.

#STTT #OpenAccess: doi.org/10.1038/s413...

Researchers identify #DKK3 as a driver of radiation-induced #SkinFibrosis, where keratinocyte DKK3 promotes ROS, TGF-β/Wnt signaling, and M2 #MacrophagePolarization; DKK3 deficiency reduces dermal hyperplasia and fibrosis. @dkfz.bsky.social @umich.edu

#STTT: doi.org/10.1038/s413...

An integrin αvβ3 targeting programmed delivery platform encapsulating Ce6 and BRD4 degrader ARV-825 mitigates CCL5-induced #PhotodynamicTherapy resistance and enhances anti-tumor immunity through #Epigenetic modulation.

#STTT #OpenAccess: doi.org/10.1038/s413...

CXCR4hi #CARTcells boost #TumorTracking, #BoneMarrow homing, and persistence, enhancing #Antitumor activity; early trial data in B cell malignancies show multiple complete responses, supporting #CXCR4 modification.

#OpenAccess in #STTT: doi.org/10.1038/s413...

This #STTT study shows that #Osimertinib disrupts the MYLK4–CDKAL1 interaction, inhibits pT43-CDKAL1 phosphorylation, and CDKAL1-dependent SALL2 translation to inhibit #CancerStemness & #Chemoresistance in #Rhabdomyosarcoma.

#OpenAccess: doi.org/10.1038/s413...