Eric Pietras

Our newest preprint is now online! We lift up the hood on TET2 mutant clonal hematopoiesis and show that oxidative metabolism is a critical feature of TET2 deficient HSPC - in mice and humans. We also find compensatory control of redox state is a key selective mechanism and potential vulnerability.

It was so much fun having you visit Katherine!

The Nicotinamide Salvage Pathway is a Metabolic Vulnerability of High-Risk MDS Stem Cells High-risk myelodysplastic syndrome (HR-MDS) is a malignant clonal disorder originating in hematopoietic stem and progenitor cells (HSPCs). The current standard of care for HR-MDS patients is hypomethy...

Our study examining the role of the nicotinamide salvage pathway in #MDS and its potential for therapeutic exploitation is now available as a preprint: www.biorxiv.org/content/10.6...
Thanks to our collaborators and funding from Evans Foundation and Blood Cancer United!

I'll be spinning some tunes on my old hometown airwaves today (Dec. 21st) at 2pm Central Time over on WLTL @wltl881.bsky.social - steam live on demand at wltl.net!

Rewriting the Rulebook of Blood At ASH 2025, Eric Pietras, PhD, highlights how aging, inflammation, and metabolism drive clonal hematopoiesis—and shape cancer and cardiovascular risk.

#ASH25: Did you know that clonal hematopoiesis affects at least 20% of adults over 60? Cancer Center's @ericpietras.bsky.social, PhD, shares his insights on the role of this condition in cancer and aging at the 2025 American Society of Hematology Presidential Symposium ⬇️
https://bit.ly/3KOKdoi

So proud of Dr. Sweta Patel, who gave a fantastic #ASH25 talk about her science in high-risk myelodysplastic syndrome. Way to go Sweta!

We also want to recognize three past ACS grantees who were invited speakers during marquee symposia during #ASH25:

- Dr. Scott Armstrong MD, PhD (ASH-EHA Joint Symposium)
- Dr. @ericpietras.bsky.social (ASH Presidential Symposium)
- Dr. John DiPersio (ASH Presidential Symposium)

Congrats all!

🧪

Glad we got to see your science! Thanks Vikram!

What an awesome stem cell session speaker group for #ASH25 Workshop on Myeloid Development @vangalenlab.bsky.social @thekinglab.bsky.social @paralkarlab.bsky.social Sandra Pinho and Allison Yeh (love the photobomb!)

Thank you!!

ASH is coming! Excited to present alongside Vikram Paralkar, Sandra Pinho, Peter Van Galen, and Alison Yeh at the stem cell session of the myeloid workshop on Friday. @ericpietras.bsky.social will be moderating— don’t miss it!

@bff.fm is 12 years old this week! I've had the pleasure to be a DJ at this awesome radio station for over 11 of those. Like any community media, BFF.fm is a nonprofit and relies on its listeners and fans for support. Head on over to BFF.fm/12years and celebrate with us!

Me, I'm all for the precision. It just sits better on the ears. Really just wherever the intention lies.

Those demos were pretty interesting. The Album Leaf has always been a very precise and well produced project, so interesting to hear something more raw and visceral - less precision but a lot of feel.

Sounds In The Dark - 7.23.25 — Sounds In The Dark on BFF.fm Sounds In The Dark with Eric Pietras on BFF.fm. Listen to show archives, or tune in live Tuesday 12:00 – 2:00am. BFF.fm is a San Francisco community radio station supporting emerging and underground a...

New synthesizer fun Sam Prekop. New release of (very old) Album Leaf demo tapes. A preview of some future sounds from Oren Ambarchi. This was a fun show. Tune on in. bff.fm/broadcasts/4...

a man wearing sunglasses and a green jacket is standing in a crowd and says `` do it '' . ALT: a man wearing sunglasses and a green jacket is standing in a crowd and says `` do it '' .

Heading to Orlando this December for ASH 2025? Have cool unpublished science about myeloid/hematopoietic stem cell biology you'd like to present at this year's Myeloid Workshop?

Then get in touch - send me an email or message on this platform! Seriously. Do it.

Hi Sierra - all hematology research, leukemia, immunology etc!

The Myeloid Workshop is back in ASH! Please contact the organizers if you have an exciting story that will not be out by December they are: Zuzana Tothova ,
@ernstlaboratory.bsky.social
@steidluli.bsky.social
@ericpietras.bsky.social
@kathrinbernt.bsky.social
@gritsmanlab.bsky.social

Daniel Herskedal | Movements of Air - Edition Records “Movements of Air” is the highly anticipated fifth album from Daniel Herskedal’s acclaimed trio, featuring Eyolf Dale on piano and Helge Andreas Norbakken on drums... [more]

Absolutely looking forward to this record - Daniel Herskedal is a true innovator in jazz - editionrecords.com/releases/dan...

Sounds In The Dark - 4.1.25 — Sounds In The Dark on BFF.fm Sounds In The Dark with Eric Pietras on BFF.fm. Listen to show archives, or tune in live Tuesday 12:00 – 2:00am. BFF.fm is a San Francisco community radio station supporting emerging and underground a...

The last time I got to play new music from Tortoise on @bff.fm was back in 2016 - until this week! Great new single out that leads off this week's edition of Sounds In The Dark. bff.fm/broadcasts/4...

Whoohoo! Congrats @juliamaxson.bsky.social and see you in CO next week!

Do Stem Cell ‘Memories’ Trigger Autoimmune Disease Flare-Ups? New research raises the possibility that 'memories' held within blood stem cells may trigger autoimmune disease flares over a person’s lifetime.

Big thanks to @cuanschutz.bsky.social for a profile of our lab's trained immunity work in autoimmune disease. March is #AutoimmunityAwarenessMonth and a good time to consider the importance of NIH @altnih4science.bsky.social and the agencies supporting such work. news.cuanschutz.edu/news-stories...

Jeremy Berg is helping keep researchers nationwide up to date The Pitt Health Sciences official and former Science editor in unique position to unofficially track funding upheavals.

Looking for some good up-to-date information on all the back and forth on science at the federal level? @jeremymberg.bsky.social is a helpful source. Great profile from Pitt on his efforts.

www.utimes.pitt.edu/news/jeremy-...

Sometimes it's good to turn down the noise. This week's edition of Sounds In The Dark is streaming on demand at @bff.fm bff.fm/broadcasts/4.... Ambient and interesting music to quiet the mind.

AACR Legislative Action Center: Your Voice Matters Directly contact your elected officials about the importance of cancer research, the need for continued funding and the latest lifesaving breakthroughs. In the United States, you can do so by sending ...

Science is for everyone. It's not a political football. If you're one of my colleagues, a radio show listener at @bff.fm, or just happening by, please be sure to contact your local representative and let them know.

www.aacr.org/professional...

2025 Board of Directors Election - International Society for Experimental Hematology

Things are gnarly in US politics, but there's one sort of voting where we're all on the same side --

Be sure to vote for the new slate of @isehsociety.bsky.social officers. I'm honored to have been nominated as a candidate for Board of Directors. Vote here:

www.iseh.org/page/2025Ele...

Gift Songs, by Jefre Cantu-Ledesma 5 track album

This is just a phenomenal new record from Jefre Cantu-Ledesma - really shakes up some of his well-worn tropes toward drone-inflected music by adding a talented cast of musical collaborators. Utterly immersive. Worth getting on vinyl. jefrecantu-ledesma.bandcamp.com/album/gift-s...

Any time Shannon :) Come on over!!

Since the new year, I've protected some time to get back in the lab and do science. With all the noise and confusion out there it's a wonderful experience to get focused and make some impactful discoveries again. A great reminder of why we do this.

Niche-derived Semaphorin 4A safeguards functional identity of myeloid-biased hematopoietic stem cells - Nature Aging Toghani, Gupte et al. identify semaphorin 4A as a cell-extrinsic factor that protects myeloid-biased hematopoietic stem cells from inflammaging, mainly produced by their progeny—neutrophils—and acting...

Congratulations to Lev Silberstein and collaborators!

www.nature.com/articles/s43...