Diego Balboa

Hyperinsulinaemia as a cause of obesity and cardiometabolic diseases - Nature Reviews Endocrinology This Review outlines the potential role of hyperinsulinaemia as an independent driver of obesity and obesity-related conditions. Evidence regarding the potential causes of hyperinsulinaemia are summar...

Hyperinsulinema, adiposity weight gain and #obesity Associations vs. causality #insulin www.nature.com/articles/s41...

🚨 Job Alert - Please share! 🙏

Interested in 3D gene regulation in development & evolution? 🤓🧬

💥 Our lab at @cabd-upo-csic.bsky.social is expanding!

We’re recruiting:
✅ PhD students
✅ Postdocs
💻🧪 Experimental or computational backgrounds welcome

👇 Details below

Native chromatome profiling reveals hundreds of metabolic enzymes in the nucleus across tissues - Nature Communications Here proteomic chromatome analysis shows metabolic enzymes widely localize to chromatin in cancer in a tissue-specific manner. Nuclear enzymes affect DNA damage/repair and transcription, revealing non...

New paper out in Nature Communications:
www.nature.com/articles/s41...
We found >250 metabolic enzymes on chromatin.
Only ~20 had been reported before.
This means hundreds of metabolic enzymes may have unexplored nuclear roles.

Stem cell therapies ‘come of age’ with two conditional approvals in Japan Induced pluripotent stem cells could help treat diseased hearts and brains

An advisory panel to Japan’s health ministry has recommended limited marketing approval for therapies using induced pluripotent stem cells for heart failure and Parkinson’s disease. https://scim.ag/4bj5iBw

Two decades of iPS cell research. By my friend and colleague @gladstoneinst.bsky.social Shinya Yamanaka, in @cp-cellstemcell.bsky.social www.cell.com/cell-stem-ce...

Sheep and pig #gastruloids, @IftachN: www.biorxiv.org/content/10.6...
The accumulating knowledge of the relationship between #SCBEMs and #Embryos, allow us to learn about species similarities and differences in gastrulation and body plan elaboration.

The role of KRAB zinc-finger proteins in expanding the domestication potential of transposable elements - Nature Genetics This Perspective explores the co-evolution of transposable elements and KRAB zinc-finger proteins in relation to their integration into human gene regulatory networks, highlighting their potential eff...

Find our latest Perspective article in Nature Genetics on "The role of KRAB zinc-finger proteins in expanding the domestication potential of transposable elements" at www.nature.com/articles/s41..., with implications for the future of research on the cause of human disease.

Reminder:

Preprint Editors – Development's next step into the preprint landscape Summary: This Editorial announces a call for Preprint Editors in Development to help expand the journal's relationship with preprints by curating our ‘In preprints’ articles.

New from @dev-journal.bsky.social: we're launching a new initiative and hiring Preprint Editors to help navigate the growing world of preprints in developmental & stem cell biology

Join our community & shape the future of research

journals.biologists.com/dev/article/...

The figure shows gene expression analysis of unsorted, CD49 sorted and CD19 sorted SCβ-cells using NanoString analysis.

Luo Ting Huang, Yaser Tahamtani, @nictitate.bsky.social & co explored the possibility of magnetic selection of insulin-expressing stem cell‑derived β‑cells using a CRISPR/Cas9 technology and transmembrane glycoprotein CD19 as a marker.

@bcchresearch.bsky.social

Read: doi.org/10.1242/dmm....

SEL1L-HRD1 endoplasmic reticulum (ER)-associated degradation (ERAD) is a regulator of PC2 biology and an essential mechanism for maintaining α cell function and glucagon biosynthesis www.nature.com/articles/s41...

Chromatin spatial analysis by METALoci unveils sex-determining 3D regulatory hubs Nature Structural & Molecular Biology - METALoci, a new three-dimensional genome computational tool, reveals a major rewiring of regulatory interactions during sex determination. By combining...

🤩💪 Out now! 3D regulatory hubs in sex determination

With @mamartirenom.bsky.social & Capel labs, led by @imotagom.bsky.social & @jrotwitguez.bsky.social

1️⃣ METALoci – explore #3DGenome 🧬
2️⃣ Non-coding region controlling Fgf9 🧩
3️⃣ Meis genes = new key players 🌟

👉 rdcu.be/e5sm2

1/n Bluetorial 👇

Progress!

You still have 3 days to apply to the postdoc positions available in my lab 😀
🔬Come and work with us 🔬

Antibody cocktails based on the occupationally acquired immunity of pediatricians neutralize and confer protection against RSV and hMPV Antibody cocktails derived from pediatricians cooperatively neutralize and protect rodents against RSV and hMPV by targeting conserved epitopes.

By isolating immune cells from pediatricians, researchers in #ScienceTranslationalMedicine employed rational design to engineer cocktails of monoclonal antibodies that neutralize #RSV and #metapneumovirus in rodents without generating resistance. https://scim.ag/4rZKe8J

Losing sleep over #iPSC transgene silencing after differentiation?
Same here.

Bright in iPSCs.
Gone after differentiation.

Our paper in @cp-cellstemcell.bsky.social maps what actually keeps expression on👇
www.cell.com/cell-stem-ce...
🔗 Free access (50 days):
www.sciencedirect.com/science/auth...

Thrilled to share the primary focus of my PhD thesis work, now out in @science.org today!

We developed Trikines — engineered cytokines that reconfigure receptor complex assembly to reshape signaling directly in endogenous immune cells.

t.co/UCixfysaUl

Finding one mutation that improves a protein is hard. Finding five that work together is exponentially harder.

Today in @science.org, Hsu and Konermann labs present MULTI-evolve, a lab-in-the-loop framework that does it in just one machine learning-guided round.

Jennifer Doudna’s $1 Billion Plan To Bring Gene Editing To The Masses Crispr’s ability to cut genetic code like scissors has just started to turn into medicines. Now, gene editing pioneer Jennifer Doudna wants to build an entire ecosystem to bring these treatments mains...

“The best that I can do in terms of making the next breakthrough or discovery is not to do it by myself, but to enable other scientists to do it”
— Jennifer Doudna

www.forbes.com/sites/amyfel...

We‘re looking for a motivated Master student to join our team!

Do you want to optogenetically control metabolic activity to see how metabolism affects patterning and morphogenesis? 💡🧫🧬🔬

Then please apply!
#optogenetics #metabolism #devbio #hESCs

Please RT. Thank you!🙏

Delighted to share our latest preprint "Filopodia-mediated trans-endocytosis"

www.biorxiv.org/content/10.6...

Work driven by many people including Hanna, Marcela, Sujan, Marie-Catherine, Anna and Monika. Fantastic collaboration with Johanna Englund, Emilia Peuhu, and Eija Jokitalo

Improving rigor in stem cell research: New study in Stem Cell Reports highlights gaps in reporting and shows how implementing ISSCR standards can strengthen reproducibility in human stem cell studies. https://ow.ly/7PiO50Yey7Y

Cell Press | The Gairdner Foundation | SickKids Foundation

Here is a robust biochemical & functional difference between young and old mammalian cells:

- The fraction of new amino acids incorporated into proteins.

The difference is consistent, quantitative, cell-type specific, and deeply intriguing.

What aging mechanisms cause it ?

1/

One thing I just learned from Bad Bunny is that very careful preparation and attention to every detail, moment by moment, in crafting a presentation can do wonders

Single-cell perturbations decipher ribosomal stress-surveillance regulators in type 2 diabetes - Nature Metabolism The authors use Perturb-seq analysis in human pancreatic islet beta cells, as well as in vivo and in vitro analyses, to identify potential therapeutic targets for type 2 diabetes, including ZZEF1, whi...

RESEARCH | J Nan, X He, X Liu, Y Cao et al (SJTU, CN)

A combination of Perturb-seq, in vitro and in vivo analyses in mice and human islet beta cells identifies therapeutic targets for type 2 diabetes🧪

www.nature.com/articles/s42...

The lab turns 4 ⌛️🐭⏳👤

Science happened…

More productive & fun than ever.

Huge thanks to the amazing lab members who make it all possible!!

(Light-sheet microscope movie by Berta Cava Cami)

Join us this week for the next exciting VGZT session! 🎉

🗓️ Thursday, February 5th
⏰ 9:30 PST / 12:30 EST / 17:30 UTC / 17:30 GMT / 18:30 CET

Our speakers are
👉 Evgeny Kvon (@evgenykvon.bsky.social)
👉 Silas Boye Nissen (on X: @SilasBoyeNissen)

See you on Thursday! 👋

Behind the paper: “Spatially organized cellular communities shape functional tissue architecture in the pancreas” - the Node Behind the paper story from Alejo Torres Cano on their recent paper describing how spatially organized cellular communities shape functional tissue architecture in the pancreas.

👀 Check out @the-node.bsky.social where
@alejotorrescano.bsky.social (first author) share
#behindthepaper stories about our recent paper
⤵️

Behind the paper: “Spatially organized cellular communities shape functional tissue architecture in the pancreas” thenode.biologists.com/behind-the-p...

Bar chart showing the number of electoral democracies by age globally in 2024. Most countries are not democracies (91 out of 179 countries with data); and most countries that are democratic are younger than a lifetime. For example, 19 countries have been electoral democracies for between 1–18 years. The data source is V-Dem (2025). The chart is licensed CC BY to Our World in Data.

To some young people living in democracies, authoritarianism may seem like a long-forgotten part of their country’s history.

(🧵1/23) First month of 2026: complete✅! Many papers coming from CIRTN scientists, including works from the labs of Drs Bruin, Lynn, Estall, Ferdaoussi, Fullerton, Hull-Meichle, Pepper, Korbutt, Levings, Lim, Mulvihill, Rabasa-Lhoret, Riddell, Rutter, Tsai, Woo and Verchere! 📝