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Dr Sarah Mitchell

@sarahmitchellphd

Staff Scientist @ Ludwig Princeton Branch

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28.11.2024
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Latest posts by Dr Sarah Mitchell @sarahmitchellphd

Happy birthday! More dad jokes!

10.03.2026 15:50 πŸ‘ 1 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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Language model-guided anticipation and discovery of mammalian metabolites - Nature Chemical language models trained on known metabolites can identify previously unknown metabolites from mass spectrometry-based metabolomics data with high accuracy.

#NatMetabPicks | In @nature.com led by @skinnider.bsky.social ( @princeton.edu ) πŸ§ͺ

DeepMet is a chemical language model designed to predict the existence of previously unrecognized metabolites.

www.nature.com/articles/s41...

02.03.2026 15:12 πŸ‘ 5 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0
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Deadline Extended! This funding opportunity offers support that will integrate specialized resources across the NSCs of Oklahoma, the University of Washington, and the Jackson Laboratory. Learn more in the updated RFA here: bit.ly/4a1TN0B

20.01.2026 17:01 πŸ‘ 2 πŸ” 2 πŸ’¬ 0 πŸ“Œ 1
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✨ Did you know JAX offers free, self‑paced online MicroLessons (15 minutes) and Mini‑Courses (1–2 hours)?

πŸ‘‰ MicroLessons: https://education.learning.jax.org/page/online-microlessons
πŸ‘‰ Mini‑Courses: https://education.learning.jax.org/page/online-minicourses

02.01.2026 11:17 πŸ‘ 4 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0

What an amazing opportunity!

05.01.2026 16:14 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
Cancer treatments accelerate ageing - Nature Reviews Cancer While cancer treatments are essential for patient survival, they often induce premature ageing-related conditions in survivors. In this Comment, Demaria outlines how understanding the underlying molecular mechanisms of this is crucial for developing integrated strategies to improve long-term health outcomes in survivors.

In our current Focus issue, #AgeingandCancer, Marco Demaria outlines how understanding the underlying molecular mechanisms of cancer treatment induced premature ageing-related conditions is crucial for developing integrated strategies to improve survivor health.

15.10.2025 15:54 πŸ‘ 3 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0

β€œOne man’s trash is another man’s treasure” 😬

03.08.2025 20:38 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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The source of dietary fat influences anti-tumour immunity in obese mice - Nature Metabolism This study shows that animal-based high-fat diets accelerate tumour growth and impair anti-tumour response to melanoma in obese mice, whereas plant-based high-fat diets do not.

The source of dietary fat influences anti-tumour immunity in obese mice #immunometabolism
Great work from @lydialynch.bsky.social lab and colleagues
www.nature.com/articles/s42...

25.07.2025 16:21 πŸ‘ 11 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0
AAV gene therapy for Cockayne syndrome Cockayne Syndrome (CS) is an autosomal recessive, progressive developmental and neurodegenerative disease. Approximately 30% of cases are caused by mutations in the ERCC8/CSA gene. Patients with CS present with cutaneous photosensitivity, growth failure, shorter life span and a progressive degeneration of the central nervous system. Loss of function mutations in CSA result in deficiencies in transcription-coupled nucleotide excision repair, regulation of RNA Pol II mediated transcription repair of oxidative DNA damage, and mitochondrial metabolism. Currently there are no available therapies for these patients. AAV gene therapy offers an opportunity to address this unmet need. We designed a new AAV vector encoding human CSA under a CBA promoter. We tested the therapeutic efficacy of this AAV9-CSA vector by neonatal ICV injection in the Csa-/-;Xpa-/- mouse model. Treatment with AAV9-CSA resulted in a significant increase in lifespan, and broad distribution of human CSA in the brain and heart. Despite clear therapeutic benefit, we also observed neuroradiological abnormalities, neuropathologic alterations including hypo-myelination, astrocytosis, microgliosis, and likely life limiting transcriptomic alterations in liver at endpoint. Nonetheless, the success of these experiments paves the way for the first in human clinical translation of a gene therapy for CS patients. ### Competing Interest Statement The authors have declared no competing interest.

www.biorxiv.org/content/10.1...

06.07.2025 15:17 πŸ‘ 2 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0

Super cool!

24.05.2025 00:41 πŸ‘ 3 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Congrats @asaelroichman.bsky.social excited to read!!

19.05.2025 20:47 πŸ‘ 9 πŸ” 2 πŸ’¬ 1 πŸ“Œ 0

Camilla is a horse face.

10.05.2025 15:29 πŸ‘ 9 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Wrong Sarah Mitchell!

20.03.2025 15:58 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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The time is now: accounting for time-of-day effects to improve reproducibility and translation of metabolism research Nature Metabolism, Published online: 17 March 2025; doi:10.1038/s42255-025-01237-6This broad group of authors summarizes the impact of circadian factors on metabolic biology and offers recommendations on how to account for and report biological,…
17.03.2025 11:04 πŸ‘ 12 πŸ” 9 πŸ’¬ 0 πŸ“Œ 0
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Contribution of vaccination to improved survival and health: modelling 50 years of the Expanded Programme on Immunization Since 1974 substantial gains in childhood survival have occurred in every global region. We estimate that EPI has provided the single greatest contribution to improved infant survival over the past 50...

Nothing will kill more children than the ongoing decimation of CDC, NIH, and USAID work to lift vaccine uptake in the US and world.

Child survival rose 75% in the last 50 years. Vaccines account for 40% of that. Measles vax alone was 60% of the benefit. www.thelancet.com/journals/lan...

13.03.2025 12:05 πŸ‘ 3534 πŸ” 1694 πŸ’¬ 52 πŸ“Œ 76

Oooh that Elon felon one is good!

06.03.2025 02:56 πŸ‘ 3 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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Biomarkers of aging: functional aspects still trump molecular parameters - npj Aging Biomarkers of aging are indispensable for testing interventions. While promising, the recent focus on molecular aspects should not detract from the functional parameters for which excellent correlatio...

... gait speed. Still better than anything molecular biomarkers can provide. Our commentary (with @regula-furrer.bsky.social @biozentrum.unibas.ch @unibas.ch) out now in NPJ Aging:

doi.org/10.1038/s415...

3/3

03.03.2025 14:15 πŸ‘ 12 πŸ” 4 πŸ’¬ 1 πŸ“Œ 0
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Renowned geneticist Francis Collins retires from NIH, urging 'respect' for embattled workers Dr. Francis Collins, a renowned geneticist, and former longtime director of the National Institutes of Health, is retiring from the government agency and urging β€œrespect” for its embattled workers.

"When you hear about patients surviving stage 4 cancer because of immunotherapy, that was based on NIH research over many decades. When you hear about sickle cell disease being cured because of CRISPR gene editing, that was built on years of research supported by NIH"

apnews.com/article/nih-...

01.03.2025 21:44 πŸ‘ 334 πŸ” 125 πŸ’¬ 2 πŸ“Œ 9
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Francis Collins, the NIH Director for 12 years, led the Human Genome Project and other NIH efforts for 32 years, resigned today. Key words from his resignation letter
www.nytimes.com/2025/03/01/u...

01.03.2025 18:07 πŸ‘ 3134 πŸ” 1385 πŸ’¬ 61 πŸ“Œ 94

Shocking.

27.02.2025 17:33 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Glycocalyx dysregulation impairs blood–brain barrier in ageing and disease - Nature Disruption of mucin-domain glycoprotein expression and function in the endothelial glycocalyx are associated with ageing and Alzheimer’s disease, leading to dysregulated blood–brain barrier function.

Happy to share this new #glycotime work with collaborator Tony Wyss-Coray, led by grad student Sophia Shi, mucin loss at the BBB is associated with aging and cognitive decline, can be reversed by restoration with with gene therapy. Aging is a mucinopathy!

www.nature.com/articles/s41...

26.02.2025 21:44 πŸ‘ 216 πŸ” 59 πŸ’¬ 2 πŸ“Œ 3
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U.S. early-career researchers struggling amid chaos Uncertain funding, government firings, and distressed universities hit vulnerable groups especially hard

A whole generation of early career scientists and physician-scientists, including colleagues and myself, are particularly vulnerable to these funding freezes and cuts, with jobs and careers depending on federal grants.

#IDsky
#Medsky
#Episky

www.science.org/content/arti...

22.02.2025 12:08 πŸ‘ 3893 πŸ” 1015 πŸ’¬ 166 πŸ“Œ 67

This is an example of research that will save lives but would be blocked by the current administration:

21.02.2025 17:48 πŸ‘ 25 πŸ” 10 πŸ’¬ 0 πŸ“Œ 0
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Great to see AFAR! We need more of this! @afar.org

21.02.2025 15:36 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

So if Musk doesn’t run DOGE, and DOGE isn’t a real government agency, then no one has to listen to Musk or do what the DOGE bros tell them to do, right?

18.02.2025 02:30 πŸ‘ 8865 πŸ” 2718 πŸ’¬ 606 πŸ“Œ 154
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Donald Trump and Elon Musk are trying to cut funding for cancer and rare disease research.

A federal judge temporarily blocked the cuts in some states, but this fight is not over.

We can’t let them play politics with our health.

14.02.2025 19:06 πŸ‘ 3152 πŸ” 530 πŸ’¬ 121 πŸ“Œ 27
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Welcome to the Bluesky account for Stand Up for Science 2025!

Keep an eye on this space for updates, event information, and ways to get involved. We can't wait to see everyone #standupforscience2025 on March 7th, both in DC and locations nationwide!

#scienceforall #sciencenotsilence

12.02.2025 17:04 πŸ‘ 11493 πŸ” 5432 πŸ’¬ 291 πŸ“Œ 670

This!!!!

13.02.2025 17:06 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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How much Elon Musk makes from the government a day: $8 million.

How much a senior on Social Security gets a day: $65

Guess which budget Musk and Trump want to cut?

12.02.2025 18:07 πŸ‘ 27593 πŸ” 11803 πŸ’¬ 863 πŸ“Œ 966

Government isn't a business. The goal isn't to save money. Success isn't measured by budget surplus.

The goal is to spend money, investing in society. Every dollar spent on education, healthcare, and science is an investment in our collective wellbeing.

08.02.2025 23:23 πŸ‘ 188 πŸ” 54 πŸ’¬ 2 πŸ“Œ 1