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Muriel Perron

@murielperron

CNRS researcher interested in neural stem cells, retina, and regeneration

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12.11.2024
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Latest posts by Muriel Perron @murielperron

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European Amphibian Conference 2026, July 3-5, 2026, Prague, Czech Republic www.xenbase.org/xenbase/doNe... #science #devbio #xenopus #frogs

19.02.2026 15:24 👍 9 🔁 5 💬 0 📌 2
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🐸 Amphibians take over Europe!!
📍 Prague. July 3–5, 2026.

The European Amphibian Conference 2026 is coming: 3 days of cutting-edge science, bold ideas, iconic speakers, and serious frog & axolotl energy ✨

👉 Register. Submit. Be there. Do not miss it.
amphib-conf2026.sciencesconf.org?lang=en

10.02.2026 12:24 👍 6 🔁 4 💬 0 📌 0
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Oriented cell divisions induce basal progenitors and regulate neural expansion across tissues and species A fundamental role for division orientation in progenitor output driving cortical and retinal growth is revealed.

Happy to announce that our latest paper is now out! Have you ever wondered how neural tissues control their size? In this paper, we show that cell division orientation is critical in both the cortex and retina. www.science.org/doi/10.1126/...

04.02.2026 19:16 👍 92 🔁 31 💬 5 📌 2
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Long-term genetic mark and recapture in Astyanax mexicanus cave populations: demographic inferences and conservation issues - Conservation Genetics The cave populations of Astyanax mexicanus in northeastern Mexico are the subject of intensive study as a model for investigating evolutionary processes in subterranean environments. Investigating key...

➡️ This study is complemented by a compagnon study focused on the conservation of Mexican tetra blind cave fish 🔽🔽🔽

27.01.2026 13:38 👍 2 🔁 1 💬 0 📌 0
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Water Parameters and Hydrodynamics in Rivers and Caves Hosting Astyanax mexicanus Populations Reveal Macro‐, Meso‐ and Microhabitat Characteristics From 2009 to 2025, we have recorded the physicochemical parameters of the water and the hydrological regimes at localities hosting Astyanax mexicanus cavefish and surface fish populations in Mexico. ...

➡️ In a new Ecology and Evolution paper, Sylvie Rétaux's team @neuropsi.bsky.social and collaborators report on more than 15 years of field studies on the water physicochemical parameters and hydrodynamic regimes in the Mexican tetra blind cave fish habitat 🐟💦.

➡️ Learn more 🔽🔽🔽

27.01.2026 13:22 👍 3 🔁 1 💬 1 📌 0
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Saclay_master_in_neuroscience sDrive

🧠 👩‍🎓 University Paris-Saclay launches its all-new Master in Neuroscience!

One M1 in neuroscience, followed by three M2:
1️⃣ Cognition, Behavior and Mental disorders.
2️⃣ Systems Neuroscience: from cells to brain functions.
3️⃣ Computational Neurosciences and Neuroengineering.

🔽🔽 Learn more & apply:

23.01.2026 16:01 👍 8 🔁 5 💬 1 📌 1
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🦾/💪 Interested in the physiology of motor control? In robotics? In neuroprosthetics?

▶️ Join us in NeuroPSI for NeuroControl 2026, the conference on the physiology and engineering of limb and prosthesis closed-loop control!

▶️ Register and submit your abstract: neurocontrol.sciencesconf.org

20.01.2026 14:50 👍 4 🔁 4 💬 0 📌 1
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👏 Upcoming seminars at NeuroPSI in January (11:30am):

➡️ The 23rd, Marc Dhenain, Institut de Biologie François Jacob, "Pseudo-prions to treat neurodegenerative diseases."

Followed by two speakers on motor control:
➡️ The 27th, Maarten Zwart, from St Andrews.
➡️ The 30th, Graziana Gatto, from Cologne.

18.01.2026 21:05 👍 3 🔁 1 💬 0 📌 0
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🎖️Toutes nos félicitations à Sylvie Rétaux, cheffe de l'équipe DECA à NeuroPSI, qui a été nommée au grade de Chevalier de la Légion d’Honneur !

18.01.2026 20:18 👍 13 🔁 2 💬 0 📌 1
PNAS Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

Second paper is a collaboration with Jim Handa's lab at Hopkins. Cigarette smoke exposure induces aging-related molecular changes in both mouse and human retinal pigment epithelium.
www.pnas.org/doi/10.1073/...

16.01.2026 21:11 👍 8 🔁 1 💬 0 📌 0
Sox8 and Sox9 regulate differentiation and nuclear positioning of retinal Müller glia Temporal patterning of retinal progenitor cells governs the sequential generation of retinal cell types, with gliogenesis occurring late in development. Sox8 and Sox9, members of the SoxE transcription factor family, are highly expressed in late-stage retinal progenitor cells and mature Müller glia, yet their functional roles remain incompletely defined. Here we employed gain- and loss-of-function approaches, single-cell multiomic profiling, and injury models to investigate Sox8/9 function. Overexpression of SOX8 and/or SOX9 in early-stage retinal progenitor cells suppressed early-born cell fates and promoted photoreceptor generation, consistent with a role in late-stage temporal identity. Conversely, conditional deletion of Sox8 and/or Sox9 in late-stage progenitors did not impair Müller glia specification, but caused radial displacement of Müller glia nuclei into the outer retina and modest changes in glial gene expression. Loss of Sox8/9 in mature Müller glia modestly increased proliferation post-injury without inducing neurogenic competence. These findings suggest that Sox8/9 are dispensable for gliogenesis and repression of neurogenic competence, but are essential for proper laminar positioning and maturation of retinal Müller glia. ### Competing Interest Statement S.B. is a cofounder, shareholder, and scientific advisory board member of CDI Labs LLC, and receives research support from Genentech. National Eye Institute, https://ror.org/03wkg3b53, R01EY036173

The lab's first paper of the new year is out. In it, we investigate the role of the late stage retinal progenitor-enriched SoxE family factors Sox8 and Sox9 in controlling retinal development./1
www.biorxiv.org/content/10.6...

16.01.2026 20:17 👍 27 🔁 6 💬 3 📌 0

I am very happy (and a bit scared) to present to you what we have been working on over the last 4 years. This manuscript is exactly what I dreamt of when I started the lab and I could not be happier and prouder of the outcome!

10.01.2026 09:42 👍 154 🔁 63 💬 23 📌 2
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..and on the 9th, at 11:30am, we will hear Ariel Levine, from NIH Bethesda, talk about "Building the Spinal Cord". Join us for these two talks at @neuropsi.bsky.social !

05.01.2026 15:17 👍 2 🔁 1 💬 0 📌 0
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📅 NeuroPSI Seminar Series. On the 8th of January at 10:30am, we will be hosting Colline Poirier, Biosciences Institute of Newcastle University.

▶️ She will talk about: "Using spontaneous behaviour to assess primate welfare"

05.01.2026 15:15 👍 1 🔁 1 💬 1 📌 0

Join the development of the mouse forelimb prosthesis as a post-doc, apply!

05.01.2026 13:00 👍 1 🔁 3 💬 0 📌 0

Congratulations!! We look forward to welcoming you at #NeuroPSI

22.12.2025 12:51 👍 1 🔁 0 💬 0 📌 0

Really happy to join NeuroPSI at Paris Saclay to lead a research group funded by an ERC Consolidator grant #ERCCoG . We'll study the origins of the vertebrate brain using shark embryos. 🦈 🧠 Reach out if you are interested in joining the team 🤍

22.12.2025 07:47 👍 71 🔁 12 💬 12 📌 0
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Sylvie Granon, chercheuse à NeuroPSI, a participé à une émission de SynapseTV, la première webTV dédiée à la santé mentale, autours de la thématique des écrans et de leur impact sur le cerveau:
www.youtube.com/watch?v=d1v9...

21.12.2025 00:09 👍 2 🔁 1 💬 0 📌 0
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Congratulations to our NeuroPSI team leader Carole Escartin for the 2025 Prize Marie-Paule Burrus from @frm-officiel.bsky.social !

21.12.2025 00:10 👍 4 🔁 1 💬 0 📌 0
Valérie Lavallée Grâce à son parcours autodidacte remarquable, Valérie Lavallée a connu une progression de carrière constante jusqu’à être nommée responsable de la plateforme de zootechnie de l’Institut des Neurosciences Paris-Saclay (NeuroPSI - CNRS/Université Paris-Saclay), situé sur le campus du CEA Saclay. En 2021, elle a notamment relevé le défi de l’installation d’une plateforme de zootechnie multi-espèces lors du déménagement du laboratoire. En 2025, le CNRS décernera la médaille de cristal à Valérie Lavallée pour la qualité de son travail et pour son rôle majeur dans ce déménagement, qui a permis le regroupement des sites zootechniques de Gif-sur-Yvette et Orsay vers le nouveau bâtiment de NeuroPSI. Cette plateforme est désormais une vitrine de l’excellence en zootechnie scientifique.

💎 Valérie Lavallée, responsable de la plateforme de zootechnie de l’Institut des Neurosciences Paris-Saclay, a obtenu la Médaille de cristal du CNRS 2025: une récompense pour son parcours et sa contribution essentielle à la recherche dans notre institut !

21.12.2025 00:11 👍 4 🔁 1 💬 0 📌 0
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🙋‍♀️ Welcome to Marion Rivalan, who joins NeuroPSI as a CNRS Junior Professor!
➡️ Her project will leverage AI-based methods for the classification and prediction of individual profiles of model animals housed in a naturalistic environment.
➡️ Learn more: neuropsi.cnrs.fr/en/marion-ri...

21.12.2025 00:13 👍 4 🔁 1 💬 0 📌 0
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🙋‍♀️ We are welcoming Idoia Quintana Urzainqui to NeuroPSi as a junior Professor! In her new team, she will research the Mechanisms that shaped early vertebrate brains, thanks to funding from a 2025 ERC Consolidator grant.

➡️ Learn more here: neuropsi.cnrs.fr/en/idoia-qui...

21.12.2025 00:14 👍 13 🔁 1 💬 0 📌 1
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A bit late but a paper from our lab has been published!
Human fingertip regeneration is a fact, it happens in children and adults (not only in children as it has been long believed). We describe here the regenerative phases and analyse the proteome of wound exudates.

www.nature.com/articles/s41...

18.12.2025 14:11 👍 22 🔁 12 💬 1 📌 0

🚨We are recruiting two PhD students 🚨

1) Quantitative & dynamic analysis of limb-regenerative signaling centers w/ @osvaldo-chara.bsky.social 📶🧮💻
🔗https://www.phd.tuebingen.mpg.de/80704/Quantitative-and-dynamic-analysis-of-limb-regenerative-signaling-center-interactions

17.12.2025 07:53 👍 8 🔁 12 💬 1 📌 1
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Could axolotls hold the key to restoring human vision? Axolotls can regenerate optic nerves, retinas, and parts of their brain. Provost's Undergraduate Research Award-winner Ted Chor wants to understand how.

Recent Hopkins Hub article highlighting our work on optic nerve regeneration in axolotl. Congratulations to Ted!
hub.jhu.edu/2025/12/11/s...

12.12.2025 13:53 👍 9 🔁 3 💬 0 📌 0
Overexpression of Meis factors in late-stage retinal progenitors yields complex effects on temporal patterning and neurogenesis - Scientific Reports The vertebrate retina serves as a model for studying neurogenesis and cell fate specification, with retinal progenitor cells following a tightly regulated temporal sequence to generate distinct cell t...

A couple of papers are finally out too. First, Meis factors are (unfortunately) not sufficient to respecify temporal identity in retinal progenitor cells.
www.nature.com/articles/s41...

12.12.2025 13:57 👍 6 🔁 2 💬 0 📌 0
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Ptbp1 is not required for retinal neurogenesis and cell fate specification Loss of function of Ptbp1 in retinal progenitors leads to changes in RNA splicing but does not affect neurogenesis and cell fate specification.

Second, not only does Ptpb1 not repress neurogenesis in adult glia, it doesn't do much in the developing CNS either. Scratch another master regulator off the list.
doi.org/10.7554/eLif...

12.12.2025 13:59 👍 7 🔁 1 💬 0 📌 0
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We have opened a call for a post-doctoral researcher !
Our team @touchmovelab.bsky.social researches strategies to provide direct cortical feedback during brain-machine interface control of an upper limb prosthesis in the mouse model.

10.12.2025 12:44 👍 0 🔁 1 💬 0 📌 2
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Specialized signaling centers direct cell fate and spatial organization in a mesodermal organoid model Stem cell–derived mesodermal organoids reveal how signaling centers guide cell fate and tissue organization.

🎉 Our deconstructed, stem-cell–based approach to studying signaling centers and limb-development cell types is out! 🥳 So nice to see it in its final form after the preprint— and huge thanks to the community for all the enthusiasm and interest since then!
www.science.org/doi/10.1126/...

02.12.2025 09:14 👍 65 🔁 21 💬 5 📌 2
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👩‍🎓 Upcoming thesis defense !

▶️ Cinthia Hernandez Puente will soon defend her PhD on the Redox control of stemness in the Xenopus retina 🐸👁️🧠, supervised by Morgane Locker, in the team of @murielperron.bsky.social.

📅 Join her at NeuroPSI on December the 16th at 1:30pm !

28.11.2025 21:07 👍 2 🔁 1 💬 0 📌 0