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SebastiΓ‘n Jara

@jsebajara

NeurobiΓ³logo πŸ‡¨πŸ‡± | postdoc @scrippsresearch| Sensory neurons-immune interaction | Axon plasticity

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13.11.2024
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Latest posts by SebastiΓ‘n Jara @jsebajara

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Assistant/Associate/Full Professor in Senescence & Cellular Aging - Buck Institute - Career Page Apply to Assistant/Associate/Full Professor in Senescence & Cellular Aging at Buck Institute in NOVATO, CA.

The Buck Institute for Research on Aging invites applications for a faculty position honoring the scientific legacy of Dr. Judith Campisi, a pioneer in the field of cellular senescence and its roles in aging and age-related disease. Job Link:
buckinstitute.applytojob.com/apply/lpV3rx... #sciencejobs

26.01.2026 18:35 πŸ‘ 6 πŸ” 5 πŸ’¬ 0 πŸ“Œ 0

Your gut has a sex, and it matters! πŸ”₯
In females, the ovary sends a relaxin hormone signal to enteric neurons, switching on gut enlargement and increased feeding after mating.
So excited my postdoc work is finally out as a preprint πŸ₯³
www.biorxiv.org/content/10.6...

11.01.2026 17:19 πŸ‘ 29 πŸ” 9 πŸ’¬ 0 πŸ“Œ 0

πŸ§ βš‘οΈπŸ’ŠNew @nature.com publication !

Mimicking opioid analgesia in cortical pain circuits

We built a brain-behavior framework to decode spontaneous chronic pain in miceβ€”and to biologically mimic morphine with a synthetic opioid gene therapy

nature.com/articles/s41...

@pennmedicine.bsky.social

08.01.2026 18:01 πŸ‘ 68 πŸ” 18 πŸ’¬ 2 πŸ“Œ 3
Cartoon transparent human with skeleton showing, red glowing points on joints to indicate pain

Cartoon transparent human with skeleton showing, red glowing points on joints to indicate pain

Do YOU live with joint pain?

Do YOU experience poor pain management?

Have you got 2-minutes to tell pain researchers about it?

If yes πŸ‘‰ forms.gle/7NTwma2gnVN1...

We hope to gain insight into lived experience for those with joint pain & involve people in our #PainResearch πŸ˜ƒ

20.12.2025 09:57 πŸ‘ 11 πŸ” 12 πŸ’¬ 0 πŸ“Œ 0

🚨New paper from the NIH PRECISION Human Pain Network! We built a human DRG reference atlas: >500K cells from 126 donors to reveal 22 neuronal & 10 non-neuronal cell types. New insights into human sensory biology!
Paper: biorxiv.org/content/10.1...
Data: humandrg.painseq.com

07.11.2025 04:43 πŸ‘ 17 πŸ” 9 πŸ’¬ 3 πŸ“Œ 0

🧠🌟🐭 Excited to share some of my postdoc work on the evolution of dexterity!

We compared deer mice evolved in forest vs prairie habitats. We found that forest mice have:
(1) more corticospinal neurons (CSNs)
(2) better hand dexterity
(3) more dexterous climbing, which is linked to CSN number🧡

22.10.2025 20:41 πŸ‘ 378 πŸ” 124 πŸ’¬ 19 πŸ“Œ 26

Coming to SD 🌴 for #SfN25 🧠?! Join @storiesofwin.bsky.social for our first in-person event 🀩. We’ll have a keynote, panels, & time for networking! Won’t be in SD? You can still register to receive a recording! Speaker/panelist announcements coming soon πŸ‘€

Register by Nov 1: forms.gle/CJPcKZNZY7uU...

09.10.2025 23:57 πŸ‘ 17 πŸ” 5 πŸ’¬ 0 πŸ“Œ 0
Labelled axons of calb1+ spinal projection neurons innervate multiple brain targets associated with cold sensation and thermoregulation. Darkfield images of different brain areas including the postal parabrachial and periaqueductal grey are shown with axons of ascending cells in yellow.

Labelled axons of calb1+ spinal projection neurons innervate multiple brain targets associated with cold sensation and thermoregulation. Darkfield images of different brain areas including the postal parabrachial and periaqueductal grey are shown with axons of ascending cells in yellow.

New preprint from the spinal cord group at Glasgow. Anatomical and functional characterisation of spinal circuits for cold, from sensory neurons to the brain…..https://www.biorxiv.org/content/10.1101/2025.10.03.680240v1

04.10.2025 08:34 πŸ‘ 23 πŸ” 8 πŸ’¬ 2 πŸ“Œ 0
Sign In JavaScript is required. This web browser does not support JavaScript or JavaScript in this web browser is not enabled.

We’re hiring!
My new Gut–Brain Axis Lab at Northwestern is looking for a Research Technologist 2 to help build the lab and explore how the nervous system shapes gut health and disease.
πŸ”¬ Apply here: myhr.northwestern.edu/psp/hrnu/EMP...

30.09.2025 22:32 πŸ‘ 43 πŸ” 23 πŸ’¬ 2 πŸ“Œ 1
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Development and Validation of a Machine Learning-Derived Kinematic Deviation Index for the Evaluation of Forelimb in Rodents | AI in Neuroscience Background: Rodent models are widely used to study neurological conditions and assess forelimb movement to measure functional performance, deficit, recovery, and treatment effectiveness. Traditional a...

Great collaboration with Abel Torres EspΓ­n that arose from our work on SCI. Congrats to all involved, including @jsebajara.bsky.social , Amanda Bernstein, Marwa Soliman, and Yunuen Moreno LΓ³pez!

www.liebertpub.com/doi/abs/10.1...

29.09.2025 16:22 πŸ‘ 2 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0

Does anyone have favorite colors for color blind friendly fluorescence images on a black background where the overlap combinations of 3 colors are important?

Magenta/cyan/yellow overlaps are difficult to distinguish (lots of white)

Thank you!

11.09.2025 17:11 πŸ‘ 0 πŸ” 1 πŸ’¬ 2 πŸ“Œ 0
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Enkephalin-producing regulatory T cells in the skin restrain local inflammation through control of nociception Regulatory T cells curb noxious sensory signaling to dampen cutaneous inflammation, a neuromodulatory mechanism for immunosuppression.

Big congrats to Alejandra @thepenkpanther.bsky.social on her new SI paper! Kicking off the Mendoza Lab’s work on sensory neuron-immune interactions. Glad to see our image highlighted on their website too!
www.science.org/doi/10.1126/...

09.09.2025 17:27 πŸ‘ 10 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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Preprint -
Excited to present WHOLISTIC, which extends the concept of whole-brain functional imaging to the entire body. Pioneering work by incredibly talented Virginia Ruetten @vmsruetten.bsky.social, this platform reveals whole-organism cellular dynamics in vivo.
www.biorxiv.org/content/10.1...

08.09.2025 16:23 πŸ‘ 194 πŸ” 70 πŸ’¬ 3 πŸ“Œ 6
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Enkephalin-producing regulatory T cells in the skin restrain local inflammation through control of nociception Regulatory T cells curb noxious sensory signaling to dampen cutaneous inflammation, a neuromodulatory mechanism for immunosuppression.

After many years of work I’m so happy to share our work on #scienceimmunology on how Treg cells modulate nociception to dampen skin inflammation! My handle will make a lot more sense now!πŸ•΅πŸ»β€β™€οΈ

05.09.2025 18:53 πŸ‘ 22 πŸ” 8 πŸ’¬ 0 πŸ“Œ 1
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Very proud that our human PNS atlas is finally published in @natcomms.nature.com We found perineurial hyperplasia and lipid-associated nerve macrophages in #polyneuropathies.
Explore: pns-atlas.mzhlab.com
A tweetorial 1/13
doi.org/10.1038/s414...

24.08.2025 13:07 πŸ‘ 16 πŸ” 5 πŸ’¬ 1 πŸ“Œ 3
JCI - Cell and molecular profiles in peripheral nerves shift toward inflammatory phenotypes in diabetic peripheral neuropathy

This work is finally online as in-press preview!

JCI - Cell and molecular profiles in peripheral nerves shift toward inflammatory phenotypes in diabetic peripheral neuropathy www.jci.org/articles/vie...

19.08.2025 16:55 πŸ‘ 34 πŸ” 15 πŸ’¬ 2 πŸ“Œ 0
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Liftoff: New lab alerts Learn about early-career scientists starting their own labs.

In this month’s β€œLiftoff,” @janetsong.bsky.social shares how she plans to expose trainees to new ideas during lab meetings and Rachel Parkinson emphasizes the importance of taking a step back and reminding yourself about the joys of science.

By @franciscorr25.bsky.social

bit.ly/4mFNGCQ

13.08.2025 15:23 πŸ‘ 23 πŸ” 6 πŸ’¬ 1 πŸ“Œ 1

As Requested - A Starter Pack of PIs in Biology (or adjacent) fields who are recruiting POSTDOCS! Please don't hesitate to reach out if you wish to be added! go.bsky.app/4gbXXR3

18.07.2025 18:33 πŸ‘ 123 πŸ” 79 πŸ’¬ 15 πŸ“Œ 3
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Professor in Neuroimmunology - DEMENTIA RESEARCHER The Salk Institute seeks a Professor in Neuroimmunology to lead innovative research on nervous and immune system interactions within a world-class setting

The Salk Institute seeks a Full Professor in Neuroimmunology to lead innovative research on nervous and immune system interactions within a collaborative, world-class setting. Closing date: 7th September

www.dementiaresearcher.nihr.ac.uk/job/professo...

10.07.2025 12:39 πŸ‘ 4 πŸ” 8 πŸ’¬ 0 πŸ“Œ 0
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Barcoded viral tracing identifies immunosuppressive astrocyte–glioma interactions - Nature Using viral barcode tracing to detect interactions between glioblastoma cells and non-malignant astrocytes in patient samples, investigators discovered a pathway that reduces tumour-specific immunity ...

Our newest paper studying immunosuppressive astrocyte-GBM interactions using RABID-seq is out in β€ͺ@nature.com today! Congrats to Brian Andersen and Camilo Faust Akl!
www.nature.com/articles/s41...

25.06.2025 20:44 πŸ‘ 34 πŸ” 16 πŸ’¬ 0 πŸ“Œ 0
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Expansion microscopy reveals nano-scale insights into the human neuromuscular junction Ramadan et al. employ expansion microscopy to visualize neuromuscular junctions in human and mouse muscles. Their findings demonstrate expansion microscopy as an accessible and cost-effective approach...

New paper from the lab 🚨: Expansion microscopy reveals nano-scale insights into the human neuromuscular junction: Cell Reports Methods www.cell.com/cell-reports...

16.06.2025 14:45 πŸ‘ 46 πŸ” 12 πŸ’¬ 3 πŸ“Œ 2
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Calling all Neuroscience postdocs! 🧠 Share your research through SPiNES (Seminars from Postdocs in Neuroscience: Extramural Series) from the NYUGSoM Department of Neuroscience. Applications close 08/20/25. Apply today! πŸ‘‰ nyumc.qualtrics.com/jfe/form/SV_...
#Neuroscience #Postdoc #ResearchOpportunity

15.06.2025 16:20 πŸ‘ 61 πŸ” 39 πŸ’¬ 1 πŸ“Œ 0
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AxoDen: An Algorithm for the Automated Quantification of Axonal Density in Defined Brain Regions The rodent brain contains 70,000,000+ neurons interconnected via complex axonal circuits with varying architectures. Neural pathologies are often associated with anatomical changes in these axonal pro...

🧠🐁

Interested in a quick / reliable / reproducible tool to quantify your fluoresently-tagged axons ?

Check out AxoDen, a no-coding-needed web app and downloadable GUI ...

Designed + developed entriely by the amazing Raquel Adaia Sandoval Ortega

www.eneuro.org/content/12/6...

14.06.2025 13:02 πŸ‘ 13 πŸ” 4 πŸ’¬ 1 πŸ“Œ 0

Happy to share my first publication with @patrikernfors.bsky.social Lab - all about the DRG: Chromatin accessibility, single cell and spatial RNA sequencing - a great source for everyone interested in sensory neurons and non-neuronal cell of the DRG 😊

13.06.2025 15:01 πŸ‘ 4 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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Choroid plexus apocrine secretion shapes CSF proteome during mouse brain development Nature Neuroscience - The choroid plexus (ChP) provides molecular cues for brain development. However, the underlying mechanisms are unclear. This study identifies an apocrine secretion mechanism...

Led by @scienceyael.bsky.social & out today in @natneuro.nature.com: the brain's fluid-secreting organ β€” the choroid plexus β€” can reshape neural development through a powerful, little-known process. & it can be hijacked by serotonergic drugs like LSD. πŸ§ πŸ‘‡ A thread
rdcu.be/eoaSY

28.05.2025 12:56 πŸ‘ 59 πŸ” 20 πŸ’¬ 3 πŸ“Œ 5
Heatmap from the linked paper in figure 2, of hDRG and nerve proteomics showing the detection of TRP- and SCN- channels across samples, with higher levels of myelin-related proteins in the nerve and higher levels of TRPV1 and SCN10a in the ganglia

Heatmap from the linked paper in figure 2, of hDRG and nerve proteomics showing the detection of TRP- and SCN- channels across samples, with higher levels of myelin-related proteins in the nerve and higher levels of TRPV1 and SCN10a in the ganglia

We set out to map a detailed proteome of the human DRG and nerve using DIA-MS as a reference to the field, and I think we've succeeded! Lots of proteins (& lots of ion channels), with the data is fully searchable. It's also available on @sparc.science

sensoryomics.shinyapps.io/Proteomics/

20.05.2025 05:58 πŸ‘ 6 πŸ” 6 πŸ’¬ 1 πŸ“Œ 0

Our lab's 1st paper, led by @fchrisbennett.bsky.social & @waisenberg.bsky.social. A decade thinking how to directly assess the impact of microglia replacement. Yrs of hard work. This kind of work is needed to expand brain disease care for kids & the vision for safer, more effective cell therapy.

30.04.2025 21:20 πŸ‘ 47 πŸ” 20 πŸ’¬ 3 πŸ“Œ 0

πŸ€πŸ–€

19.04.2025 22:42 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Interoceptive processing in the nucleus of the solitary tract The interoceptive nervous system continuously monitors the status of visceral organs to synthesize internal perceptions and regulate behavioral and ph…

Lots of recent papers discuss the nucleus of the solitary tract in interoception. In this review, we take a sensory processing perspective on how interoceptive signals are encoded in the NTS:
www.sciencedirect.com/science/arti...

16.04.2025 04:02 πŸ‘ 55 πŸ” 19 πŸ’¬ 0 πŸ“Œ 3
Join Chemsymposia 2026: Research & Innovation | ChemSymposia 2026 Join us at Chemsymposia 2026 to discover groundbreaking research in physics applications. Connect with experts, engage in insightful discussions, and explore our venue, registration details, and speak...

SCAM ALERT. This is a fake conference that ripped off my and other people’s names to trick people into registering. There is no such conference that I or the others shown were invited or agreed to. We are working to try to get this fraud taken down from the web.

chemsymposia.com

11.04.2025 16:35 πŸ‘ 194 πŸ” 108 πŸ’¬ 8 πŸ“Œ 6