Gergo Porkolab

Super thankful for everyone involved – this was a huge collaborative effort between vascular biologist and biophysicist labs co-led by Maria Deli, Robert Horvath and @mattcampbelltcd.bsky.social

Endothelial tight junctions and cell-matrix adhesions reciprocally control blood-brain barrier integrity Brain endothelial cells (ECs) rely on mechanical cues to provide a physical barrier that protects the brain. Yet how ECs integrate forces to establish and maintain the blood-brain barrier (BBB) remain...

Happy to share our new preprint on BBB mechanobiology on bioRxiv:
www.biorxiv.org/cgi/content/...

We describe an exciting new link between tight junctions and cell-matrix adhesions during BBB maturation and in epileptic BBB dysfunction.

Proteome profile differences among human, monkey, and mouse brain microvessels and cultured brain microvascular endothelial cells - Fluids and Barriers of the CNS Background The blood-brain barrier (BBB) expresses transporters, receptors, and tight junction proteins that regulate the exchange of substances between the blood and brain. The differences in the exp...

fluidsbarrierscns.biomedcentral.com/articles/10....

Enhanced retinal pigment epithelial cells as a delivery vehicle for retinal disease Age-related macular degeneration (AMD) is one of the leading causes of central retinal blindness. Here, Campbell and colleagues show that transplanted retinal pigment epithelial cells can be engineere...

New paper led by Avril Reddy in @mattcampbelltcd.bsky.social lab showing IPS derived human RPE cells expressing aflibercept and/or soluble CD59 can attenuate lesions in mouse model of age-related macular degeneration. Cool project to help out with. www.cell.com/molecular-th...