Michael Kharas

Genetic variant appears to protect some people against certain blood cancers Researchers found a genetic variant that appears to protect against the development of CHIP, a phenomenon that can lead to certain blood cancers

And nice coverage by @angusrohan.bsky.social from @statnews.com (3/n): www.statnews.com/2026/01/01/b...

Genetic resistance to leukemia A genome-wide association study identifies a genetic variant that reduces the risk of leukemia

Please check out this terrific preview from Caido & Manz (2/n): www.science.org/doi/10.1126/...

Delighted to have our work on 🧬 resilience to 🩸cancer led by @g-agarwal.bsky.social & amazing collaborators, including @kharaslab.bsky.social, published in @science.org: www.science.org/doi/10.1126/... 🧵

Inherited resilience to clonal hematopoiesis by modifying stem cell RNA regulation Somatic mutations that increase the fitness of hematopoietic stem cells (HSCs) drive their expansion in clonal hematopoiesis (CH) and predispose individuals to blood cancers. Population variation in t...

New @science.org today
Discovery of a genomic variant that protects against blood cancer by reducing risk of CHIP (blood stem cell mutation clones, common with aging)
@bloodgenes.bsky.social
@kharaslab.bsky.social
science.org/doi/10.1126/...

Kitlo hematopoietic stem cells exhibit distinct lymphoid-primed chromatin landscapes that enhance thymic reconstitution Nature Communications - Hematopoietic stem cells (HSCs) differentiate into multiple lineages, with such capacity impacted by aging. Here the authors identify Kitlo HSCs as a functionally distinct...

HAPPY 4th and excited to be part of this. Congrats to the talented Dr. Harold Elias for getting this epic Nature Comm story rdcu.be/euQb7 on how kitlow HSCs have superior thymic reconstitution. Big congrats to Marcel Van Den Brink and all of our collaborators!!

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So excited to be part of this amazing story.

So proud of this incredible work from @g-agarwal.bsky.social from our group with help from many fantastic folks in our lab and inspiring collaborators, including @kharaslab.bsky.social, Alex Bick, @yashpershad.bsky.social, and many others! Please check out Gaurav's awesome 🧵👇👇

Patricia Ernst told me that this is the new twitter. Not sure let’s see.