Ishitani Lab

ER Stress Ire1‐Xbp1s Pathway Maintains Youthful Epidermal Basal Layer Through the Regulation of Cell Proliferation In young epidermal basal layer, the Ire1-Xbp1s endoplasmic reticulum (ER) stress-response pathway maintains cell proliferation by activating the cell cycle regulator Vcp, whereas the age-dependent de....

VERY HAPPY to share our new paper in Aging Cell (doi.org/10.1111/acel...). We discovered the unexpected roles of ER stress in youthful skin maintenance, using ultra-short lived killifish and spacial transcriptomics PIC. #aging #killifish

Excited to share our latest review article published in Seminars in Cell & Developmental Biology "Mechanical force-driven cell competition ensures robust morphogen gradient formation"
authors.elsevier.com/sd/article/S...

Our recent paper featured in a Nature Communications Editors’ Highlights (the 50 best papers recently published)!!
www.nature.com/collections/...

Swimming Into Future Breakthroughs From Kyoto, Japan: Report of the 18th International Zebrafish Conference (IZFC2024) IZFC2024, held from August 17 to 21, 2024, in Kyoto, Japan, attracted 641 researchers from 38 countries. The conference fostered investigation, innovation, and collaboration in zebrafish research, in...

The meeting report of the international zebrafish conference (IZFC2024) "Swimming Into Future Breakthroughs From Kyoto, Japan:"has been published in Genes to Cells.
onlinelibrary.wiley.com/doi/10.1111/...

異常細胞除く「細胞競合」、因子特定で可視化　大阪大 - 日本経済新聞 大阪大学の石谷太教授らは、正常な細胞が異常な細胞を排除する「細胞競合」に関わる遺伝子を特定した。この遺伝子を活用すれば、除去される異常細胞を可視化できる。細胞競合が起きる場所や時期を調べられ、病気の解明や医薬品の開発などにつながる可能性がある。細胞は分裂をくり返して増殖し、臓器や組織を形づくる。人間や動物の体には増殖の過程でできた異常な細胞を除去する細胞競合という現象がある。この働きが低下する

異常細胞除く「細胞競合」、因子特定で可視化　大阪大 - 日本経済新聞 www.nikkei.com/article/DGXZ...

Cell competition corrects noisy Wnt morphogen gradients to achieve robust patterning in the zebrafish embryo - Nature Communications Gradients of morphogens such as Wnt provide instructive cues for cell identities during development. Here, the authors report that in the developing zebrafish embryo, cell competition and elimination ...

This paper follows on from our cell competition paper published 5y ago (nature.com/articles/s41467-019-12609-4), 2y ago (nature.com/articles/s41467-022-29061-6), and last month (science.org/doi/10.1126/sciadv.adp2357).
We have demonstrated that cell competition ensures vertebrate tissue robustness❗️

Foxo3-mediated physiological cell competition ensures robust tissue patterning throughout vertebrate development - Nature Communications Physiological roles of cell competition in vertebrates and the universal mechanisms regulating diverse cell competition are unknown. Here, authors show that Foxo3-mediated physiological cell competiti...

EXCITED to share our new paper in Nat Commun @natureportfolio.bsky.social "Foxo3-mediated physiological cell competition ensures robust tissue patterning throughout vertebrate development”, identifying a potential marker of cell competition. #zebrafish #cellcompetition
www.nature.com/articles/s41...

Foxo3-mediated physiological cell competition ensures robust tissue patterning throughout vertebrate development - Nature Communications Physiological roles of cell competition in vertebrates and the universal mechanisms regulating diverse cell competition are unknown. Here, authors show that Foxo3-mediated physiological cell competiti...

The longevity factor Foxo3 mediates “unfit” cell elimination to ensure both precise development and cancer prevention

Open Access
www.nature.com/articles/s41...