Shinji Izuka

Honored to be invited to the 15th Congress of the Egyptian Society of Rheumatology & Clinical Immunology (EGYSIR 2025) Online Review Course!

I’ll present “Anti-synthetase syndrome—an update: from phenotype recognition to precision therapy.”

#Myositis #ASyS

Excited to share that I’ll be presenting our latest scRNA-seq research on PBMCs from patients with idiopathic inflammatory myopathies at #APLAR25. #myositis

Looking forward to returning to APLAR after some time and meeting friends and colleagues in Fukuoka 🇯🇵

Shared molecular profiles of anti-PL12 autoantibodies in anti-synthetase syndrome AbstractObjectives. Anti-PL12 autoantibodies are targeted against alanyl-tRNA synthetase, a cytosolic enzyme which plays a vital role in protein synthesis.

academic.oup.com/rheumatology...

Beyond simple positivity: dissecting anti-PL-12 antibodies as a blueprint for future therapeutics in anti-synthetase syndrome Shinji Izuka; Beyond simple positivity: dissecting anti-PL-12 antibodies as a blueprint for future therapeutics in anti-synthetase syndrome, Rheumatology,

B cell-targeted therapies (CAR-T, T cell engagers) are reshaping autoimmune disease treatment.

In my editorial, I discuss how mass spectrometry dissection of anti-PL12 antibodies in #ASyS (Ali & Troelnikov et al.) may pave the way for precision B cell therapies.

doi.org/10.1093/rheu...

Risk of infection in patients with early inflammatory arthritis: results from a large UK prospective observational cohort study AbstractObjective. To identify risk of serious infections-(SI) according to initial conventional synthetic disease modifying anti-rheumatic drugs-(csDMARD)

Risk of infection in patients with early inflammatory arthritis: results from a large UK prospective observational cohort study

doi.org/10.1093/rheu...

More than an immunosuppressant—lower serious infection rates with methotrexate in early rheumatoid arthritis Shinji Izuka; More than an immunosuppressant—lower serious infection rates with methotrexate in early rheumatoid arthritis, Rheumatology, , keaf354, https:

🦠 Early methotrexate use was associated with a 24 % lower rate of serious infections in a UK early-RA cohort (Adas et al.).

📖 My editorial asks whether MTX’s immunomodulating—rather than purely immunosuppressive—effects explain this paradox.

doi.org/10.1093/rheu...

Don't miss this brilliant paper! It really hit the nail on the head for some key challenges in managing #lupus. Was happy to make a small contribution💡

NEW for #LUPUS2025—ERN ReCONNET–SLICC–SLEuro expert consensus on the therapeutic management of rare systemic #lupus erythematosus manifestations bit.ly/3YXEmAO #SLE #Medsky #Rheumsky
Free to read with registration on lancet.com (also free)

Integration of transcriptome and immunophenotyping data highlights differences in the pathogenetic kinetics of B cells across immune-mediated disease Objective To elucidate crucial immune cell subsets and associated immunological pathways by stratifying patients with immune-mediated diseases (IMDs) using immunophenotyping and transcriptomic approac...

📝 Delighted to share our latest research!

Integration of transcriptome + immunophenotyping reveals two distinct B-cell–driven clusters across 6 IMDs — #SLE #RA #SSc #IIM #MCTD #LVV

🔔 Naïve B–dominant cluster
⬆️ IFN & ABC signature
🚨 Higher flare rate

rmdopen.bmj.com/content/11/2...

After a fulfilling four-year journey, I’m proud to share that I’ve officially completed my #PhD. It’s been an incredibly rewarding experience! I’m deeply grateful to everyone who supported me along the way.

🔔 Monocytes & Macrophages in #Myositis
— insights from our latest review!

✅ Chemokine-driven monocyte recruitment into inflamed tissue
✅ Markers predicting severity & prognosis in ILD
✅ Dysregulated IFN sig. & mitochondrial stress driving pathology

🔓 www.frontiersin.org/journals/imm...

Muscle Tissue Transcriptome of Idiopathic Inflammatory Myopathy Reflects the Muscle Damage Process by Monocytes and Presence of Skin Lesions Objective We aim to investigate transcriptomic and immunophenotypic features of muscle specimens from patients with idiopathic inflammatory myopathy (IIM). Methods Bulk RNA-sequencing was performe...

Muscle Tissue Transcriptome of Idiopathic Inflammatory Myopathy Reflects the Muscle Damage Process by Monocytes and Presence of Skin Lesions

acrjournals.onlinelibrary.wiley.com/doi/10.1002/...

Machine learning–driven immunophenotypic stratification of mixed connective tissue disease, corroborating the clinical heterogeneity AbstractObjective. The objective of this study was to stratify patients with MCTD, based on their immunophenotype.Methods. We analysed the immunophenotype

Machine learning–driven immunophenotypic stratification of mixed connective tissue disease, corroborating the clinical heterogeneity

academic.oup.com/rheumatology...

So nice!

Happy New Year 🥳
Grateful to kick off 2025 with our research being featured. Thank you for sharing ✨

Autumn in Boston 🍂

Strolling in autumn. 🍂

Looking to gather a list of all rheumatologists and rheumatology professionals!
Comment if I missed you!

#ACR24
#rheum

go.bsky.app/CEj2dcZ