S

I did know about that, but is he promoting that as part of HHS policy the way he is about saturated fats and "seed oils"?

Denialism about health risks of saturated fat would be in line with RFK Jr's views.

Oh, got it. Thank you. I think it's a combination of outrage baiting and wanting to spread the kinds of views that the author reached to as a justification for why what irritated him is actually an example of broad importance to society.

Wait, the Washington Post Op-eds are pay-to-play??

Misoprostol is also used for inducing labor (later in pregnancy). It's also off-label for that.

If you take more than one prescription medication, there's a good chance that some of your other medications are also off-label. The package insert you get when you pick them up from the pharmacy will say what the approved indications are.

No, the manufacturer had to apply for erectile dysfunction as an indicated use or they wouldn't have been able to promote it for that (and in the US, run ads!). The original clinical trials were for angina; it doesn't work well for that, the labeled indications are ED and pulmonary hypertension.

If it's an older drug the official labeling will almost never be updated. Someone, usually the manufacturer, has to pay to have a new application reviewed by the regulatory agency. Unless the drug is still under patent and they want to promote it for a new indication, there's no point.

It's a gastric ulcer medication that's been out of patent for decades. The packaging has warnings to not use it while pregnant and until recently listed pregnancy as an absolute contraindication.

For example, the most common medication used to ripen the cervix when inducing labor is off-label for that. There are mountains of research on use of it to induce labor and it's on the WHO list of essential medicines for this use.

To add a new indication for a medication, you don't just need to do research - the manufacturer has to apply to the FDA (and equivalent in other countries) to have the indication added to the labeling. It's expensive and virtually never happens for medications that are available as generics.

They're not dumb, they're doing this because they know most people don't know this so it sounds scary.

No, the manufacturers paid for some GLP-1 meds to go through the approval process for a new indication, so that they can promote those specific ones for weight loss. It's common though to prescribe based on availability rather than which indication the medication is labeled for.

Plenty of clinical guidelines even include medications that are off-label!

There are so many conditions for which an off-label medication is the standard of care, even for adults. It's extremely rare for manufacturers to go back to get additional indications added once a medication is approved, especially once it's available as a generic.

This isn't about generic vs. non-generic. It's about what the medication was approved to treat vs. the often much wider variety of things the medication is routinely used to treat.

He sure does. I looked him up at he's not only a professor at the Catholic University of America, he's a fellow at the Institute for Human Ecology there. 'Human ecology ' is a Roman Catholic concept that attempts to represent things like the RCC view on trans people as natural law.

I wouldn't be surprised if he issued some kind of proclamation on social media to that effect. I don't think the oil companies will go for it and I wouldn't bet that the Trump II administration has people who could get it done.

We participate in the global oil market and the government doesn't have control over where companies sell their oil.

I grew up in an inner suburb of Boston. I had neighbors who drove up to *New Hampshire* to buy gas. Both of the parents were engineers!

My parents did that too but I think they were mostly tracking how many miles per gallon they were getting. They bought a Prius when I was in college and the instantaneous miles per gallon was one of their favorite features.

Sure, Schumer endorsed her but she's the long-time Democratic elected official running and he's party leadership; it's not particularly meaningful that he endorsed her.

If you're worried about Democratic centrist infrastructure moving the party further to the right (which I am), even w/out his baggage it's not clear that Platner is an improvement over Mills.

The Pod Save America guys in particular, but Matt Yglesias also likes him. I'm not saying that he'd be to the right of Mills in office, just that it doesn't seem he's dramatically to the left of Mills.

Given that his supporters include parts of that centrist infrastructure, I don't buy that he's the answer to that problem.

Platner is supported not just by Bernie but by the Pod Save America guys and Matt Yglesias. I don't really get why he's seen as the progressive option or even as much of an outsider instead of as an insider w/no experience running against an insider w/experience.

Vinay Prasad, apparently: "Got to make sure the trial participants are blinded to whether they received the intervention, no possible other way to study whether something works!"

Was not expecting a Dr. Drew x Sayer Ji crossover.

I think Blendtec has the dull blades and Vita-Mix the sharp blades.

I believe this program even requires Massachusetts prisons and jails to hold people *past* their release date if ICE can't get enforcement officers there on the release date. So no, there's absolutely no way that this reduces the amount of time Massachusetts is paying to imprison someone.