*2024 what even are numbers
12.03.2026 04:36
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*2024 what even are numbers
I may or may not have shouted in horror to my therapist after the 2025 election "my country is marrying the abuser!!"
in addition to the long, determined chant of "actually, that's rape" we need to have an even longer determined chant of "actually, that's child abuse" before we'll get another chance to not vote in a steady stream of abusers, who just seem normal to a horrifying number of people
Structures of Marburgvirus glycoprotein and its complex with NPC1 receptor
doi.org/10.1038/s415...
prompt engineering: chef's kiss
My sense is for a lot of people, being able to quickly determine who can dominate whom feels like a matter of life and death. The wiring for that worldview is available in all of us, but some of us have access to other wiring some or most of the time?
I spent the last week writing up this essay on what it means to be trans in this moment. What it means to live under authoritarianism as the scapegoated minority of the moment and how it feels inescapable as an infinite loop.
www.thedissident.news/exit-conditi...
I am REALLY excited to share this manuscript from my group now on bioarxiv. Here we used the OAA lectin scaffold to ask can lectins be evolved to have specific interactions for defined glycan structures . www.biorxiv.org/content/10.6...
Suppression of individuality is an essential part of the some-ppl-are-worth-more worldview. Everyone must fit into one of the known person categories so they can be sorted at a glance. Anyone trying to avoid being instantly sorted must be whacked until they stay put in a bucket. [sob]
.0044 on 2nd try - I realized partway thru the 1st try that moving my eyes diagonally or holding my head diagonal made lines jump out where there was nothing before
it's horrifying how little humanity can be left in a person and they are still walking around attracting followers -it's like a cockroach surviving without its head. Really??? Strip away everything but the will to dominate and skill at lying and ppl are still like "sure, seems legit"
“The pessimism of the intellect means seeing the Loop for what it is with no illusions, no false exits, and no comforting narratives about the arc of history. The optimism of the will means refusing to let that clarity become paralysis.” Such powerful writing, thank you for sharing! 🏳️⚧️🫡🏳️⚧️🫡
A public database of binding-site predictions in the human proteome and a google colab notebook to use the model yourself can be found here: github.com/sokrypton/af...
I've been looking forward to this arrival. It's a wonderful project by composer Quinsin Nachoff, inspired by my writings on pattern formation. Jazz-inflected modern classical, and if you like that kind of thing (I do), you should like this. More here: quinsin.com/patterns-fro...
Hot off the press!
I'm thrilled to share that our paper "Unravelling the Maturation Pathway of a Eukaryotic Virus through Cryo-EM" has been published!
Link to the paper: www.pnas.org/doi/10.1073/...
Nature is full of remarkable protein nanomachines, and now we can watch one more in action.
Images of molecular models of ALG3 and ALG9 proteins with substates bound.
I’m very excited to share some newly published work that uncovers the molecular basis for oligomannose synthesis!
www.nature.com/articles/s41...
I'm guessing this is like the pandemic preparedness plan in DT's 1st term - plans for mitigating threats to shipping prob exist, but they fired all the people who know about them
The conversation that I was fortunate to have with @chanda.blacksky.app @harvardbookstore.bsky.social about my new book When Trees Testify: Science, Wisdom, History, and America's Black Botanical Legacy was filmed by C-SPAN Book TV & is available:
www.c-span.org/program/book...
Thanks again, Chanda!
Inhibitory neurons are among the most transcriptomically diverse class of neurons in the CNS, with some brain regions having 60+ distinct cell types. Do humans share the same repertoire as rodents? Birds? Fish? 1/13
Very interesting and significant paper showing that FOX proteins interact with HSV DNA to control latency in neurons
www.nature.com/articles/s41...
The International Progressive MS Alliance has awarded awarded a four-year grant worth over $3 million to a study led by Dr. Dawn Ehde, a clinical psychologist in the UW Medicine Division of Clinical and Neuropsychology and professor of psychology and rehabilitation medicine.
This is to say: if you're an attorney who's hesitated to take on habeas cases because you think you lack the knowledge, or you're worried about whether you'll really help, I PROMISE you can make a difference. I'm just a dipshit with a 7-year-old laptop and a bad attitude. If I can do it, so can you.
This looks like *such* a great project.
If it wasn't for the quantitative focus, I'd probably apply for it myself.
Our next Talk will be "Protein Origami and the Hidden Rules of Functional Innovations"! March 11th, 5PM CET. Sign-up here: tinyurl.com/prose-seminar2
Eradication of latent Epstein-Barr virus by hydroxyurea alters the growth-transformed cell phenotype #EBV #MECFS #LongCovid
pubmed.ncbi.nlm.nih.gov/9593003/
The human parasite, Toxoplasma gondii, is paralyzed without two components of the apical polar ring https://www.biorxiv.org/content/10.64898/2026.03.07.707822v1
If decades out some workers are able to get that pie in the sky benefit, it will be because unions started asking for it now
Condensates are powerful ways to break symmetry and cells do remarkable things with them. Here we show that in a multinucleate fungus, a condensate regulates translation of a cyclin and a formin in distinct locations.
www.nature.com/articles/s41...
Structural studies have provided new insights into lenacapavir's unique mechanism of action. Using electron cryotomography, researchers found that treatment of intact HIV capsids with lenacapavir causes capsids to rupture, with ruptures occurring first in areas of the capsid with the highest level of curvature. The walls of lenacapavir-treated capsids were observed to flatten during early time points and fragment over the course of the experiment. This process is shown in the animation, created by Rachel Torrez in collaboration with Owen Pornillos (University of Utah). The animation was created using pdb_00009pry and pdb_00009y7j and their corresponding models in the EM Data Bank, EMD-71816 and EMD-72657.
Researchers found that treatment of intact HIV capsids with lenacapavir causes capsids to rupture, with ruptures occurring first in areas of the capsid with the highest level of curvature. #ASBMB2026 #ASBMB26
Watch in 3D at PDB-101: pdb101.rcsb.org/motm...
Seriously, #EduSky, #Physics teachers, #scicomm folks, if you aren't familiar with thescienceplayground.com, you should be. Amazing collection of all kinds of science demos and games from across the web, all curated by a science game expert and, indeed, no AI!!!
