Matt Eldridge

A two-step screen identifies a small molecule that disrupts membrane voltage and is effective against growing and persister gram-negative bacteria | Microbiology Spectrum Finding new antimicrobials for gram-negative bacteria is challenging because their outer membrane is difficult to penetrate. Standard laboratory screens often miss promising candidates since they do n...

new paper from @csdetweiler.bsky.social lab.

Great work @casamoto.bsky.social !! What a nice way to end the year!

journals.asm.org/doi/10.1128/...

Congratulations, Chan. Great to see this is out. What a great story!

DMXL1 promotes recruitment of V1-ATPase to lysosomes upon TRPML1 activation - Nature Structural & Molecular Biology Lee et al. show that DMXL1, a regulator of V-ATPase assembly, is recruited to lysosomes upon TRPML1 activation in a manner dependent on conjugation of ATG8 proteins on lysosomal membranes (CASM) and p...

Chan Lee @harperlabhms.bsky.social reports CASM-driven V-ATPase recruitment to lysosomes for acidification upon TRPML1 activation via DMXL1-RAVE loader. With Magdalene Moran(Caraway), Sophie Helaine lab, Joao Paulo, & HarperLab teams(HMS). Funds: Warren Alpert FND/NIH www.nature.com/articles/s41...

Great to see this out, congratulations Chan!

DMXL1 promotes recruitment of V1-ATPase to lysosomes upon TRPML1 activation Nature Structural & Molecular Biology, Published online: 17 June 2025; doi:10.1038/s41594-025-01581-xLee et al. show that DMXL1, a regulator of V-ATPase assembly, is recruited to lysosomes upon TRPML1 activation in a manner dependent on conjugation of ATG8 proteins on lysosomal membranes (CASM) and promotes lysosomal function.

ICYMI: New online: DMXL1 promotes recruitment of V1-ATPase to lysosomes upon TRPML1 activation

“Importantly, under long-standing law and practice, NIH does not have the authority to arbitrarily terminate grants. Its funding decisions must be guided by congressional mandates, regulatory requirements, and scientific expertise, not vague and undefined criteria.”

These are extremely challenging times for early-career faculty. Here is my office's small contribution to make their hard and important work a bit easier:

Download our curated and comprehensive database of funding opportunities for early-career faculty.

Here: research.jhu.edu/rdt/funding-...

Highly multiplexed spatial transcriptomics in bacteria Single-cell decisions made in complex environments underlie many bacterial phenomena. Image-based transcriptomics approaches offer an avenue to study such behaviors, yet these approaches have been hin...

Highly multiplexed spatial transcriptomics in bacteria www.science.org/doi/abs/10.1... #jcampubs

Walgreens CEO says anti-shoplifting strategy backfired: 'When you lock things up…you don't sell as many of them’ Walgreens' CEO talked about the flip side of investing in increased security on a recent earnings call.

Walgreens CEO says anti-shoplifting strategy backfired: ‘When you lock things up…you don’t sell as many of them’

Our lab has multiple open positions for post-docs to study the regulation and function of cytoplasm mechanics during embryo development.
Details below 👇👇
Please Repost !!!

@ijmonod.bsky.social @cnrs.bsky.social

This is one of my fave lil papers highlights nutrient differences in various culture mediums with human serum levels.
And Happy Christmas to you too!!

Mind your media - Nature Metabolism Cell culture media are typically selected on the basis of common laboratory practices but have major effects on the validity, reproducibility and physiological relevance of the scientific findings. We...

www.nature.com/articles/s42...

I love studies like this! Makes me think of growth conditions in tissue culture too! :p

Getting closer to the reality of bacterial growth "in the wild".

Lab-adapted bugs are really like diabetic, force-fed versions of their wild parents. #MicroSky

#MicroSky

🚨 Call for Applications 🚨
The Institut Pasteur is recruiting junior research group leaders!

Focus on:
💉 Vaccinology & immunotherapies
🦠 Infectious diseases
🧠 Neuro-immunology and neurodevelopment
🤰 Maternal & child health

📅 research.pasteur.fr/en/call/call...
#ResearchOpportunity #ScienceJobs

Just did my first Starter Pack, I think it can be useful. Let me know if you miss any journal and I will add it. Enjoy!! go.bsky.app/QPFZpj9

Antibiotic-recalcitrant Salmonella during infection - Nature Reviews Microbiology In this Review, Giorgio and Helaine provide an overview of the physiology of antibiotic-recalcitrant Salmonella enterica during infection, discuss recent insights into the clinical implications of ant...

Another paper from the Helaine lab! This time a review! Great work from Rachel outlining definitions and concepts in studying antibiotic recalcitrance (it can be very tough to do!)

www.nature.com/articles/s41...

Join us!
4 Assistant/ Associate Professor posts available at University of Warwick School of Life Sciences, 2 in Host-Pathogen interactions and 2 in Plant Sciences:
warwick-careers.tal.net/vx/lang-en-G...

warwick-careers.tal.net/vx/lang-en-G...

#microsky

Haha thanks bud! Other than picking who to or not follow I have never been very good at curating my feed on that other site. It’s particular cesspooly now…..

A prophage competition element protects Salmonella from lysis Sargen and Helaine find a prophage-encoded anti-phage defense element that blocks the lytic cycles of co-residing prophages. They further find that prophage competition occurs in Salmonella persisters...

New paper from Helaine lab at Harvard Medical School, check it out!

www.cell.com/cell-host-mi...