Mehdi Jorfi

Immune dysfunction in Alzheimer disease - Nature Reviews Neuroscience The importance of peripheral immunity in Alzheimer disease has gained much traction in recent years, mainly due to multiple genome-wide association studies identifying risk loci associated with genes ...

Wrapping up 2025 with a collaborative paper we recently published.
We synthesize work across the field showing that peripheral immune cells are not just bystanders in Alzheimer’s disease, but active drivers of neuropathogenesis and tractable therapeutic targets.
www.nature.com/articles/s41...

Exciting postdoc opportunity! Join us to dissect immune-driven mechanisms of neurodegeneration in Alzheimer’s disease and develop therapeutic targeting strategies using stem cell engineering.
Details: bit.ly/GARUPD

Do you have a PhD in neurobiology, immunology, bioengineering, stem cell biology, or a related field? The labs of McCance Center-affiliated faculty Dr. Jorfi & Dr. Griciuc seek a Postdoctoral Fellow to conduct research in neuroimmunology. Learn more: bit.ly/GARUPD

Immune dysfunction in Alzheimer disease - Nature Reviews Neuroscience The importance of peripheral immunity in Alzheimer disease has gained much traction in recent years, mainly due to multiple genome-wide association studies identifying risk loci associated with genes ...

Immune dysfunction in Alzheimer disease — a Review by Oleg Butovsky, Neta Rosenzweig, Kilian L. Kleemann, Mehdi Jorfi, Vijay K. Kuchroo, Rudolph E. Tanzi & Howard L. Weiner

#neuroscience #neuroskyence

www.nature.com/articles/s41...

TET2-mutant myeloid cells mitigate Alzheimer’s disease progression via CNS infiltration and enhanced phagocytosis in mice Matatall et al. uncover a mutation-specific association between clonal hematopoiesis (CH) and Alzheimer’s disease (AD) in mice and humans. TET2-mutant CH conferred lower odds of AD in humans and reduc...

TET2-mutant myeloid cells mitigate Alzheimer’s disease progression via CNS infiltration and enhanced phagocytosis in mice @cp-cellstemcell.bsky.social www.cell.com/cell-stem-ce...

Congrats @sadafamin.bsky.social this is great news!!!

Microglia activation orchestrates CXCL10-mediated CD8+ T cell recruitment to promote aging-related white matter degeneration - Nature Neuroscience White matter aging leads to degenerative and inflammatory changes. Here the authors show that microglial dysfunction exacerbates glial CXCL10 expression, harmful CD8+ T cell recruitment, myelinated ax...

Microglia activation orchestrates CXCL10-mediated CD8+ T cell recruitment to promote aging-related white matter degeneration

@janos-groh.bsky.social @tum.de @synergy-munich.bsky.social @dzne.science

www.nature.com/articles/s41...

Redefining CNS immune privilege - Nature Reviews Immunology In this Perspective, Smyth and Kipnis reappraise the concept of immune privilege in the central nervous system. Although immune privilege was originally thought to involve isolation of the central ner...

Our perspective in @natrevimmunol.nature.com on new concepts in neuroimmune interactions that have challenged the old dogma that immune privilege is a result of the isolation of the nervous and immune systems.

@jonykipnis.bsky.social
www.nature.com/articles/s41...

Harnessing human iPSC-microglia for CNS-wide delivery of disease-modifying proteins Widespread delivery of therapeutic proteins to the brain remains challenging. To determine whether human induced pluripotent stem cell (iPSC)-microgli…

Congratulations to
Dr. Jean Paul Chadarevian and the entire @blurtonjoneslab.bsky.social team for this beautiful piece of work: Harnessing human iPSC-microglia for CNS-wide delivery of disease modifying proteins." 👍👍👍
www.sciencedirect.com/science/arti...

Immune checkpoint TIM-3 regulates microglia and Alzheimer’s disease - Nature The immune-checkpoint molecule TIM-3 regulates microglial homeostasis, and its microglial-specific deletion reduced cognitive impairment in a mouse model of Alzheimer’s disease.

With Butovsky Lab, we show that silencing TIM-3 in brain-resident immune cells prevents neurodegeneration in a mouse model of #Alzheimer’s disease. Deletion of TIM-3 in microglia enhance phagocytic clearance of toxic amyloid beta. #Immunosky🧪 www.nature.com/articles/s41...

Harnessing microglia-based cell therapies for the treatment of neurodegenerative diseases www.sciencedirect.com/science/arti...

Exciting work from the Albert lab on unique signatures of human basal radial glia. And look at those beautiful organoids with their basal progenitors! 🤩

Great work!! Congrats!

Today marks the 1st anniversary of the Jorfi lab! This past year has been full of challenges, growth, and exciting discoveries. I’m so proud of everything our team has accomplished and grateful to work with such an amazing group. Looking forward to more milestones ahead!

Neuroinflammation in Alzheimer disease - Nature Reviews Immunology This Review provides an in-depth examination of how inflammation contributes to neurodegeneration in Alzheimer disease. The authors explore the impact of extrinsic factors, such as brain trauma, diet ...

Neuroinflammation in Alzheimer disease

I'm thrilled to see our paper featured on the cover of
Trends in Immunology! We discuss how peripheral immune cells contribute to Alzheimer’s disease and highlight new approaches to studying neuroimmune interactions.
paper: dlvr.it/TG8M2S
#neuroimmunology #neuroimmune #Alzheimer