Super excited to finally see this out! Also, hornwort emojis need to be publicly available
05.03.2026 21:11
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Super excited to finally see this out! Also, hornwort emojis need to be publicly available
I aspire to exude as much confidence as this little Kinesin protein strutting along a microtubule while hauling intracellular cargo.
Look at that little guy go! 🔬🧪
Regret to announce that we’ve reached Wrong Coat season. Every coat you wear from now til mid April will be The Wrong Coat for the weather
The chloroplast ionome shines light on the dynamics of organellar iron homeostasis academic.oup.com/plcell/artic... @theplantcell.bsky.social
📢 New preprint alert!
How do proteins enter mitochondria? We uncovered a surprising mechanism at the mitochondrial entry gate—using #NMR, in vivo single-particle tracking, yeast experiments, and MD simulations to crack the code.
www.biorxiv.org/content/10.6...
#StructuralBiology #Mitochondria
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How does protein folding change inside biomolecular condensates?
Our new preprint put forwards a framework for predicting this!! 🥳🥳🥳🥳 work by the talented @nathanieldhess.bsky.social
Every time people focus on resolution as a competitive number rather than what biochemical detailed is revealed at that resolution is being sent this little guy
"are you enjoying duo mobile" does a hamburger enjoy being made of quarks. does a fish enjoy linear time. does the mountain enjoy the first taste of a cup of hot chocolate when you get back to the ski lodge. your question means nothing to me. i couldn't enjoy duo mobile even if i tried
New preprint! Entropy drives molecular recognition, yet most structure-based drug design ignores it because it is difficult to measure. X-ray crystallography captures ensembles, not single structures. Can we extract thermodynamically meaningful entropy from them?
www.biorxiv.org/content/10.1...
And now we have Arabidopsis plants with 8 chromosomes instead of 10 and no obvious phenotypic differences, this week in @science.org
#PlantScience
Paper here: www.science.org/doi/10.1126/...
Perspective here:
www.science.org/doi/10.1126/...
Rubisco is slow across the tree of life
@omc111.bsky.social
www.pnas.org/doi/10.1073/...
An illustration of a carbonic anhydrase complex in a synthetic mini-carboxysome
Pleased to see this collaboration with a great PhD student Pei Cing Ng, from Prof. Luning Liu's lab at Liverpool University published. Structure of the H. neapolitanus carbonic anhydrase and localisation in a mini-carboxysome: www.pnas.org/doi/epdf/10....
Every day I understand the Butlerian Jihad more and more
FLiP–MS uses a library of protein–protein interaction markers to understand protein complex dynamics go.nature.com/4dQabQw
rdcu.be/eJI3A
How does catalysis emerge from non-catalytic domains?
In our new paper, we show that catalytic activity can arise without conserved active-site residues — through multimerization and electrostatic features instead.
A striking case of catalysis evolving from binding.
This is super cool! I love the combination of computation and wet lab. The preference for slow codons in mitochondrial targeted proteins is thought provoking - presumably this could also be true of chloroplast targeted proteins
Awesome to see this epic piece of work, led by @cecclementi.bsky.social, finally appear in @natchem.nature.com.
The development of a general coarse-grained protein forcefield to describe folding, binding and conformation changes without solvent and all-atom, has been long anticipated!
New @biorxiv-biophys.bsky.social preprint from the #keedylab! 👀
www.biorxiv.org/content/10.1...
How do related proteins perform distinct functions despite sharing a similar structure?...
Working on modeling waters for the first time right now, currently leaning towards no, water is not real
I can’t wait for a coot-free future
Do structure, they said. It’ll be fun, they said. *quadsulfide bond appears*
Tennis Balls xkcd.com/3080
A Perspective by @stephanieaw.bsky.social and @fraserlab.com discusses ways macromolecules use conformational entropy to control binding, catalysis, and allostery
www.nature.com/articles/s41...
A diagrame of the molecular parts used to make a synthetic biomolecular condensate and confocal microscopy images of the condensates
Outstanding work by @anyalb.bsky.social in my lab - she targeted enzymes to synthetic biomolecular condensates in plants and showed increases in metabolic pathway activity, likely due to protection of the introduced enzymes from proteolysis
#PlantScience
onlinelibrary.wiley.com/doi/10.1111/...
Protein function often depends on protein dynamics. To design proteins that function like natural ones, how do we predict their dynamics?
@hkws.bsky.social and I are thrilled to share the first big, experimental datasets on protein dynamics and our new model: Dyna-1!
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You can download my protein structure-inspired artwork from pdb webpage:
pdb101.rcsb.org/sci-art/bezs...
@rcsbpdb.bsky.social
@pdbeurope.bsky.social
#sciart
Been thinking about creating a collection of good protein structure figures, as inspiration for my own work.
#1 www.nature.com/articles/s41...
How Ironic that on the International Day of Women and Girls in Science, Woman's portraits have been taken down at NIH and Women is a forbidden word that if found in your NSF grant could get it revoked. #womeninstem
Withdrawing US funding from the World Health Organization is a potential disaster for public health worldwide, due to the impact it will have on the important work the WHO does. Preventing the CDC from even *talking* with WHO personnel is a step much farther toward undermining global health & safety
